Lethal severe fever with thrombocytopenia syndrome virus infection causes systemic germinal centre failure and massive T cell apoptosis in cats

• Published in: Frontiers in microbiology Vol. 14; p. 1333946
• Main Authors: Sakai, Yusuke, Mura, Serina, Kuwabara, Yuko, Kagimoto, Saya, Sakurai, Masashi, Morimoto, Masahiro, Park, Eun-sil, Shimojima, Masayuki, Nagata, Noriyo, Ami, Yasushi, Yoshikawa, Tomoki, Iwata-Yoshikawa, Naoko, Fukushi, Shuetsu, Watanabe, Shumpei, Kurosu, Takeshi, Okutani, Akiko, Kimura, Masanobu, Imaoka, Koichi, Saijo, Masayuki, Morikawa, Shigeru, Suzuki, Tadaki, Maeda, Ken
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2023
• Subjects: cats; germinal centre reaction; histopathology; lymph nodes; severe fever with thrombocytopenia syndrome; histopathology; severe fever with thrombocytopenia syndrome; cats; lymph nodes; germinal centre reaction

Severe fever with thrombocytopenia syndrome (SFTS) is a fatal viral disease characterized by high fever, thrombocytopenia, leukopenia, and multi-organ haemorrhage. Disruption of the humoral immune response and decreased lymphocyte numbers are thought to contribute to the disease severity. These find...