CpG Oligodeoxynucleotides Protect Normal and SIV-Infected Macaques from Leishmania Infection

• Published in: The Journal of immunology (1950) Vol. 170; no. 9; pp. 4717 - 4723
• Main Authors: Verthelyi, Daniela, Gursel, Mayda, Kenney, Richard T, Lifson, Jeffrey D, Liu, Shuying, Mican, Joan, Klinman, Dennis M
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.05.2003
• Subjects: Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - therapeutic use; Adult; Animals; Antiprotozoal Agents - administration & dosage; Antiprotozoal Agents - therapeutic use; Cells, Cultured; CpG Islands - immunology; Female; HIV Infections - immunology; Humans; Injections, Intradermal; Leishmania mexicana - immunology; Leishmaniasis, Cutaneous - immunology; Leishmaniasis, Cutaneous - prevention & control; Leishmaniasis, Cutaneous - virology; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - virology; Macaca mulatta; Male; Oligodeoxyribonucleotides - administration & dosage; Oligodeoxyribonucleotides - therapeutic use; Protozoan Vaccines - administration & dosage; Protozoan Vaccines - therapeutic use; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - parasitology; Simian Acquired Immunodeficiency Syndrome - therapy; Simian Immunodeficiency Virus - immunology; Viral Load

Oligodeoxynucleotides containing CpG motifs (CpG ODNs) mimic microbial DNA and activate effectors of the innate immune response, which limits the spread of pathogens and promotes an adaptive immune response. CpG ODNs have been shown to protect mice from infection with intracellular pathogens. Unfort...