Time From Human Immunodeficiency Virus Seroconversion to Reaching CD4+ Cell Count Thresholds <200, <350, and <500 Cells/mm3: Assessment of Need Following Changes in Treatment Guidelines

• Published in: Clinical infectious diseases Vol. 53; no. 8; pp. 817 - 825
• Main Authors: Lodi, Sara, Phillips, Andrew, Touloumi, Giota, Geskus, Ronald, Meyer, Laurence, Thiébaut, Rodolphe, Pantazis, Nikos, del Amo, Julia, Johnson, Anne M., Babiker, Abdel, Porter, Kholoud
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.10.2011
• Subjects: Adult; AIDS; Antiretrovirals; Biological and medical sciences; Carts; CD4 Lymphocyte Count; Cohort Studies; Confidence interval; Drug Administration Schedule; Drug Therapy, Combination; Early Diagnosis; Europe - epidemiology; Female; Follow-Up Studies; HIV; HIV infections; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - immunology; HIV Infections - virology; HIV seropositivity; HIV Seropositivity - drug therapy; HIV Seropositivity - immunology; HIV-1 - immunology; HIV/AIDS; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Interval estimators; Linear Models; Male; Medical sciences; Men; Middle Aged; Mortality; Practice Guidelines as Topic; Risk Factors; Sexual Behavior; Time Factors; United States - epidemiology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; United States; Europe; Infection; Virus; Numeration; Immunopathology; Treatment; Viral disease; Retroviridae; AIDS; Human immunodeficiency virus; Immune deficiency; Lentivirus; Recommendation

Background. Recent updates of human immunodeficiency virus (HIV) treatment guidelines have raised the CD4+ cell count thresholds for antiretroviral therapy initiation from 350 to 500 cells/mm 3 in the United States and from 200 to 350 cells/mm 3 in mid- and low-income countries. Robust data of time...