Improvement of DNA recognition through molecular imprinting: hybrid oligomer imprinted polymeric nanoparticles (oligoMIP NPs)

• Published in: Biomaterials science Vol. 4; no. 2; pp. 281 - 287
• Main Authors: Brahmbhatt, H, Poma, A, Pendergraff, H M, Watts, J K, Turner, N W
• Format: Journal Article
• Language: English
• Published: England 01.02.2016
• Subjects: Antibodies - chemistry; DNA - chemistry; DNA - metabolism; Kinetics; Molecular Imprinting; Nanoparticles - chemistry; Oligonucleotides - chemistry; Oligonucleotides - metabolism; Polymers - chemistry

High affinity and specific binding are cardinal properties of nucleic acids in relation to their biological function and their role in biotechnology. To this end, structural preorganization of oligonucleotides can significantly improve their binding performance, and numerous examples of this can be...