Divergent Electrocardiographic Responses to Whole and Particle-Free Diesel Exhaust Inhalation in Spontaneously Hypertensive Rats

• Published in: Toxicological sciences Vol. 125; no. 2; pp. 558 - 568
• Main Authors: Lamb, Christina M., Hazari, Mehdi S., Haykal-Coates, Najwa, Carll, Alex P., Krantz, Q. Todd, King, Charly, Winsett, Darrell W., Cascio, Wayne E., Costa, Daniel L., Farraj, Aimen K.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2012
• Subjects: Air Pollutants - toxicity; Animals; Arrhythmias, Cardiac - chemically induced; Arrhythmias, Cardiac - diagnosis; Arrhythmias, Cardiac - physiopathology; Capsaicin - pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate - drug effects; Hypertension - complications; Hypertension - physiopathology; Inhalation Exposure; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sensory System Agents - pharmacology; Telemetry; Time Factors; Vehicle Emissions - toxicity; exhaust; diesel; SH rat; electrophysiology; gases; cardiac

Diesel exhaust (DE) is a major contributor to traffic-related fine particulate matter (PM)2.5. Although inroads have been made in understanding the mechanisms of PM-related health effects, DE's complex mixture of PM, gases, and volatile organics makes it difficult to determine how the constitue...