Diameter and dissection of the abdominal aorta and the risk of distal aortic reoperation after surgery for type A aortic dissection

• Published in: International journal of cardiology Vol. 404; p. 131938
• Main Authors: Biancari, Fausto, Perrotti, Andrea, Juvonen, Tatu, Mariscalco, Giovanni, Pettinari, Matteo, Lega, Javier Rodriguez, Di Perna, Dario, Mäkikallio, Timo, Onorati, Francesco, Wisniewki, Konrad, Demal, Till, Pol, Marek, Gatti, Giuseppe, Vendramin, Igor, Rinaldi, Mauro, Quintana, Eduard, Peterss, Sven, Field, Mark, Fiore, Antonio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2024
• Subjects: Aortic dissection; Diameter; Genetic syndrome; Loeys-Dietz syndrome; Marfan syndrome; Reoperation; Size; Type A aortic dissection; Vascular Ehlers-Danlos syndrome; Type A aortic dissection; Reoperation; Genetic syndrome; Loeys-Dietz syndrome; Size; Vascular Ehlers-Danlos syndrome; Aortic dissection; Diameter; Marfan syndrome
• ISSN: 0167-5273; 1874-1754; 1874-1754
• DOI: 10.1016/j.ijcard.2024.131938

Surgery for Stanford type A aortic dissection (TAAD) is associated with an increased risk of late aortic reoperations due to degeneration of the dissected aorta. The subjects of this analysis were 990 TAAD patients who survived surgery for acute TAAD and had complete data on the diameter and dissection status of all aortic segments. After a mean follow-up of 4.2 ± 3.6 years, 60 patients underwent 85 distal aortic reoperations. Ten-year cumulative incidence of distal aortic reoperation was 9.6%. Multivariable competing risk analysis showed that the maximum preoperative diameter of the abdominal aorta (SHR 1.041, 95%CI 1.008–1.075), abdominal aorta dissection (SHR 2.133, 95%CI 1.156–3.937) and genetic syndromes (SHR 2.840, 95%CI 1.001–8.060) were independent predictors of distal aortic reoperation. Patients with a maximum diameter of the abdominal aorta >30 mm and/or abdominal aortic dissection had a cumulative incidence of 10-year distal aortic reoperation of 12.0% compared to 5.7% in those without these risk factors (adjusted SHR 2.076, 95%CI 1.062–4.060). TAAD patients with genetic syndromes, and increased size and dissection of the abdominal aorta have an increased the risk of distal aortic reoperations. A policy of extensive surgical or hybrid primary aortic repair, completion endovascular procedures for aortic remodeling and tight surveillance may be justified in these patients. Trial registration:ClinicalTrials.gov Identifier: NCT04831073. •Distal aortic reoperations may be required after surgery for TAAD.•Genetic syndromes increase the risk of distal aortic reoperation.•Distal aortic reoperations are more frequent when the abdominal aorta is enlarged and/or dissected.•These conditions may justify extensive primary repair and completion procedures.