18F-FLT PET performs better than 18F-FDG PET in differentiating malignant uterine corpus tumors from benign leiomyoma

• Published in: Annals of nuclear medicine Vol. 26; no. 6; pp. 478 - 484
• Main Authors: Yamane, Tomohiko, Takaoka, Aki, Kita, Masato, Imai, Yukihiro, Senda, Michio
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.07.2012
• Subjects: Adult; Aged; Biological Transport; Cell Proliferation; Diagnosis, Differential; Dideoxynucleosides - metabolism; Female; Fluorodeoxyglucose F18 - metabolism; Humans; Imaging; Leiomyoma - diagnostic imaging; Leiomyoma - metabolism; Leiomyoma - pathology; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Original Article; Positron-Emission Tomography - methods; Radiology; Uterine Neoplasms - diagnostic imaging; Uterine Neoplasms - metabolism; Uterine Neoplasms - pathology; F-FDG PET; Uterine leiomyosarcoma; F-FLT PET; Uterine leiomyoma; Uterine corpus tumor

Purpose The aim of this study is to test the hypothesis that positron emission tomography (PET) with 3′-deoxy-3′-[ 18 F]-fluorothymidine ( 18 F-FLT) can differentiate malignancy from benign leiomyoma better than PET with 2-deoxy-2-[ 18 F]fluoro- d -glucose ( 18 F-FDG), and to evaluate whether 18 F-F...