Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

• Published in: eLife Vol. 12
• Main Authors: Waki, Kentarou, Tani, Hideki, Kawahara, Eigo, Saga, Yumiko, Shimada, Takahisa, Yamazaki, Emiko, Koike, Seiichi, Morinaga, Yoshitomo, Isobe, Masaharu, Kurosawa, Nobuyuki
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 08.05.2025; eLife Sciences Publications, Ltd
• Subjects: ACE2; Administration, Intranasal; Angiotensin; Angiotensin-converting enzyme 2; Animals; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antigens; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Disease transmission; Endoplasmic reticulum; Enzymes; Epitopes; Female; Humans; IgA; Immune response; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulin A, Secretory - immunology; Immunoglobulin G; Immunology and Inflammation; Infections; Intranasal administration; intranasal vaccination; Lavage; Lymphocytes B; Medical research; Mice; Mice, Inbred BALB C; Monoclonal antibodies; monoclonal antibody; Mucosal immunity; Nasal Mucosa - immunology; Peptidyl-dipeptidase A; Plasma; plasma cell; Plasma cells; Polyclonal antibodies; Prophylaxis; Proteins; SARS-CoV-2; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - administration & dosage; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Spleen; Vaccine efficacy; Vaccines; Viral infections; COVID-19; mouse; IgA; SARS-CoV-2; intranasal vaccination; inflammation; monoclonal antibody; immunology; plasma cell

Intranasal vaccination is an attractive strategy for preventing COVID-19 disease as it stimulates the production of multimeric secretory immunoglobulin A (IgA), the predominant antibody isotype in the mucosal immune system, at the target site of severe acute respiratory syndrome coronavirus 2 (SARS-...