Anterograde trafficking of Toll‐like receptors requires the cargo sorting adaptors TMED ‐2 and 7

• Published in: Traffic (Copenhagen, Denmark) Vol. 24; no. 11; pp. 508 - 521
• Main Authors: Holm, Julia E. J., Soares, Sandro G., Symmons, Martyn F., Huddin, Afiqah Saleh, Moncrieffe, Martin C., Gay, Nicholas J.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2023; John Wiley & Sons A/S
• Subjects: Adaptor proteins; Anterograde transport; Cell surface; Cell surface receptors; Golgi apparatus; Immune response; Innate immunity; Protein Transport; Receptor mechanisms; Signal transduction; TLR2 protein; TLR3 protein; TLR4 protein; TLR5 protein; TLR9 protein; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 3 - metabolism; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Toll-Like Receptors - metabolism; protein transport; p24; TLRs; endoplasmic reticulum; COP-coated vesicles

Toll‐Like Receptors (TLRs) play a pivotal role in immunity by recognising conserved structural features of pathogens and initiating the innate immune response. TLR signalling is subject to complex regulation that remains poorly understood. Here we show that two small type I transmembrane receptors,...