Pharmacokinetics of phenobarbital in horses after single and repeated oral administration of the drug

• Published in: American journal of veterinary research Vol. 53; no. 5; p. 706
• Main Authors: Knox, D.A. (Auburn University, AL), Ravis, W.R, Pedersoli, W.M, Spano, J.S, Nostrandt, A.C, Krista, L.M, Schumacher, J
• Format: Journal Article
• Language: English
• Published: United States 01.05.1992
• Subjects: Absorption; Administration, Oral; Animals; CABALLOS; CHEVAL; FARMACOLOGIA; FENOBARBITAL; Half-Life; Horses - metabolism; Liver - drug effects; METHODE D'APPLICATION; METODOS DE APLICACION; PHARMACOLOGIE; PHENOBARBITAL; Phenobarbital - administration & dosage; Phenobarbital - adverse effects; Phenobarbital - pharmacokinetics; Tissue Distribution

Six healthy mature horses were orally administered a single dose of phenobarbital (26 mg/kg of body weight), then multiple doses (13 mg/kg) orally for 42 consecutive days. Seventeen venous blood samples were collected from each horse after the single dose study and again after the last dose on day 4...