MiRNAs: a new target for Chinese medicine to repair the intestinal barrier in the treatment of ulcerative colitis

This review presents the progress of traditional Chinese medicines in the treatment of ulcerative colitis by regulating miRNAs. Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease whose pathogenesis remains unclear. Dysfunction of the intestinal mucosal barrier is closely rel...

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Published inFrontiers in pharmacology Vol. 15; p. 1446554
Main Authors Sun, Dajuan, Zhang, Zhongtao, Xue, Jingwei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2024
Subjects
intestinal mucosal barrier
mechanism of action
MicroRNAs
traditional Chinese medicine
ulcerative colitis
mechanism of action
traditional Chinese medicine
ulcerative colitis
intestinal mucosal barrier
MicroRNAs
Online AccessGet full text
ISSN1663-9812
1663-9812
DOI10.3389/fphar.2024.1446554

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Abstract This review presents the progress of traditional Chinese medicines in the treatment of ulcerative colitis by regulating miRNAs. Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease whose pathogenesis remains unclear. Dysfunction of the intestinal mucosal barrier is closely related to the pathogenesis of UC, which is characterised by damage to the colon epithelial barrier, disruption of immune homeostasis, and persistent inflammatory cell infiltration. MicroRNAs (miRNAs) exhibit specific or differential expression in both UC animal models and patients, implicating their involvement in the pathogenesis of UC. In recent years there has been progress in using Traditional Chinese medicine (TCM) to regulate miRNA expression for repairing the intestinal mucosal barrier in UC, as demonstrated in animal and cell experiments. However, it has not been applied in a clinical setting and its underlying molecular mechanisms require further investigation. Therefore, this study systematically described the role of miRNAs in UC-induced intestinal barrier damage and the application of TCM to repair this intestinal barrier by regulating miRNA expression, offering new therapeutic targets for UC treatment.
AbstractList Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease whose pathogenesis remains unclear. Dysfunction of the intestinal mucosal barrier is closely related to the pathogenesis of UC, which is characterised by damage to the colon epithelial barrier, disruption of immune homeostasis, and persistent inflammatory cell infiltration. MicroRNAs (miRNAs) exhibit specific or differential expression in both UC animal models and patients, implicating their involvement in the pathogenesis of UC. In recent years there has been progress in using Traditional Chinese medicine (TCM) to regulate miRNA expression for repairing the intestinal mucosal barrier in UC, as demonstrated in animal and cell experiments. However, it has not been applied in a clinical setting and its underlying molecular mechanisms require further investigation. Therefore, this study systematically described the role of miRNAs in UC-induced intestinal barrier damage and the application of TCM to repair this intestinal barrier by regulating miRNA expression, offering new therapeutic targets for UC treatment.
This review presents the progress of traditional Chinese medicines in the treatment of ulcerative colitis by regulating miRNAs. Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease whose pathogenesis remains unclear. Dysfunction of the intestinal mucosal barrier is closely related to the pathogenesis of UC, which is characterised by damage to the colon epithelial barrier, disruption of immune homeostasis, and persistent inflammatory cell infiltration. MicroRNAs (miRNAs) exhibit specific or differential expression in both UC animal models and patients, implicating their involvement in the pathogenesis of UC. In recent years there has been progress in using Traditional Chinese medicine (TCM) to regulate miRNA expression for repairing the intestinal mucosal barrier in UC, as demonstrated in animal and cell experiments. However, it has not been applied in a clinical setting and its underlying molecular mechanisms require further investigation. Therefore, this study systematically described the role of miRNAs in UC-induced intestinal barrier damage and the application of TCM to repair this intestinal barrier by regulating miRNA expression, offering new therapeutic targets for UC treatment.
Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease whose pathogenesis remains unclear. Dysfunction of the intestinal mucosal barrier is closely related to the pathogenesis of UC, which is characterised by damage to the colon epithelial barrier, disruption of immune homeostasis, and persistent inflammatory cell infiltration. MicroRNAs (miRNAs) exhibit specific or differential expression in both UC animal models and patients, implicating their involvement in the pathogenesis of UC. In recent years there has been progress in using Traditional Chinese medicine (TCM) to regulate miRNA expression for repairing the intestinal mucosal barrier in UC, as demonstrated in animal and cell experiments. However, it has not been applied in a clinical setting and its underlying molecular mechanisms require further investigation. Therefore, this study systematically described the role of miRNAs in UC-induced intestinal barrier damage and the application of TCM to repair this intestinal barrier by regulating miRNA expression, offering new therapeutic targets for UC treatment.Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease whose pathogenesis remains unclear. Dysfunction of the intestinal mucosal barrier is closely related to the pathogenesis of UC, which is characterised by damage to the colon epithelial barrier, disruption of immune homeostasis, and persistent inflammatory cell infiltration. MicroRNAs (miRNAs) exhibit specific or differential expression in both UC animal models and patients, implicating their involvement in the pathogenesis of UC. In recent years there has been progress in using Traditional Chinese medicine (TCM) to regulate miRNA expression for repairing the intestinal mucosal barrier in UC, as demonstrated in animal and cell experiments. However, it has not been applied in a clinical setting and its underlying molecular mechanisms require further investigation. Therefore, this study systematically described the role of miRNAs in UC-induced intestinal barrier damage and the application of TCM to repair this intestinal barrier by regulating miRNA expression, offering new therapeutic targets for UC treatment.
Author Xue, Jingwei
Sun, Dajuan
Zhang, Zhongtao
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Cites_doi 10.1073/pnas.0508517102
10.1159/000478629
10.1126/science.284.5415.770
10.1016/j.jep.2020.113243
10.13422/j.cnki.syfjx.20231711
10.1093/ecco-jcc/jjy181
10.1074/jbc.M116.749325
10.1002/ijc.25041
10.7501/j.issn.0253-2670.2024.13.012
10.3969/j.issn.1004-745X.2019.01.027
10.3390/genes9020085
10.1038/mi.2016.102
10.1038/s41575-019-0172-4
10.1053/j.gastro.2020.06.038
10.1016/j.molcel.2017.03.013
10.1093/ibd/izy107
10.2174/0115665240273807231122052445
10.1016/j.gene.2017.08.036
10.3390/genes10100752
10.27157/d.cnki.ghzku.2020.005205
10.3969/j.issn.1673-534X.2020.06.013
10.1097/SHK.0000000000000604
10.1038/s41419-018-0814-4
10.3969/j.issn.1002-266X.2024.01.001
10.3389/fimmu.2021.609319
10.1155/2020/8813558
10.1111/j.1440-1746.2009.06216.x
10.1007/s10555-022-10028-4
10.3389/fphar.2020.01067
10.1515/znc-2011-7-810
10.3390/pharmaceutics15010229
10.18632/aging.103555
10.3969/j.issn.1671-038X.2022.07.09
10.1080/00365521.2018.1447597
10.1016/j.jep.2021.113997
10.27045/d.cnki.ggyyc.2022.000302
10.1038/s41467-018-05720-5
10.1002/mnfr.202000452
10.1002/mnfr.201900633
10.1053/j.gastro.2017.01.049
10.27157/d.cnki.ghzku.2020.000606
10.1073/pnas.2005010117
10.1038/s41575-018-0081-y
10.1016/j.immuni.2010.03.017
10.1016/j.bbrc.2017.04.143
10.1038/s41385-019-0216-7
10.1038/cr.2011.137
10.1016/j.biopha.2020.109909
10.3389/fimmu.2022.871713
10.3969/j.issn.1000-4718.2021.09.005
10.3969/j.issn.1000-484X.2016.07.031
10.1080/13880209.2020.1867196
10.1016/j.bbrc.2020.04.038
10.1053/j.gastro.2019.02.023
10.27282/d.cnki.gsdzu.2022.000966
10.3389/fimmu.2020.00625
10.1016/S0140-6736(23)00966-2
10.5152/tjg.2023.21884
10.1007/s10753-021-01618-5
10.1002/cbf.3109
10.1016/j.immuni.2019.03.017
10.3969/j.issn.1674-070X.2022.09.016
10.13862/j.cn43-1446/r.2022.08.034
10.1016/j.prp.2017.10.003
10.1155/2023/2457006
10.3389/fphar.2021.707776
10.1515/jbcpp-2018-0036
10.1038/onc.2016.468
10.3390/ijms23105840
10.1093/nar/gky575
10.27180/d.cnki.gjxzc.2023.000636
10.1084/jem.20212278
10.7150/ijbs.59904
10.1186/s13072-018-0217-x
10.1002/jcla.24455
10.1155/2017/8524972
10.19540/j.cnki.cjcmm.20220713.501
10.3969/j.issn.1671-6450.2022.01.008
10.2147/DDDT.S368836
10.3892/etm.2019.8277
10.3389/fimmu.2022.855645
10.3969/j.issn.1673-7202.2022.16.016
10.3969/j.issn.1001-1528.2023.07.050
10.1016/j.jep.2023.117419
10.1002/jbt.23245
10.2147/IJN.S402179
10.1016/j.yexcr.2017.08.013
10.1136/gutjnl-2015-309389
10.1080/1028415X.2019.1594554
10.1016/j.jep.2023.117413
10.3969/j.issn.1008-8849.2021.16.002
10.1016/j.clnu.2012.03.003
10.1155/2022/1755608
10.3969/j.issn.1009-976X.2017.04.005
10.1016/j.intimp.2018.11.045
10.26355/eurrev_201903_17260
10.1155/2016/1489050
10.1016/j.ygeno.2022.110360
10.1016/j.intimp.2019.105768
10.27270/d.cnki.gsxau.2022.000382
10.18388/abp.2020_5152
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traditional Chinese medicine
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intestinal mucosal barrier
MicroRNAs
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References He (B24) 2016; 65
Takagi (B64) 2010; 25
Lv (B45) 2018; 9
An (B5) 2022; 13
Chen (B7); 12
Liu (B43) 2020; 12
Wang (B75) 2017; 36
Gehart (B18) 2019; 16
Zhang (B92) 2017; 42
Zhang (B93) 2018; 24
Li (B38) 2023; 37
Crawford (B14) 2020; 117
Song (B61) 2020; 40
Tatiya-Aphiradee (B68) 2018; 30
Xu (B84); 114
Peng (B50) 2020; 67
Wang (B74); 2022
Yang (B87) 2023; 45
Shi (B58) 2017; 10
Takahashi (B65) 2018; 46
Deng (B15) 2019; 13
He (B25); 152
Ahluwalia (B2) 2018; 53
Liu (B42) 2019; 75
Lu (B44) 2020; 19
Chen (B8) 2016; 32
Guo (B20) 2022; 45
Shi (B59) 2020; 13
Adhikari (B1) 2018; 11
Kim (B33) 2017; 66
Qiu (B52) 2022; 30
Shi (B57) 2022; 36
Artavanis-Tsakonas (B6) 1999; 284
Pasca (B49) 2020; 11
Xia (B80) 2024; 24
Chu (B13) 2018; 214
Jie (B28) 2021; 264
Xu (B83) 2017; 488
Gong (B19) 2022; 17
Qi (B51) 2022; 28
Wang (B77) 2024; 320
Chen (B9) 2020; 526
Jung (B30) 2021; 17
You (B89) 2020; 11
Yu (B90) 2023; 34
Tang (B66) 2017; 360
Yan (B85) 2020; 2020
Harikumar (B23) 2010; 127
Siddiqui (B60) 2010; 32
Zhu (B100) 2020; 126
Chen (B12) 2022; 21
Nagao-Kitamoto (B48) 2022; 41
Sun (B63) 2019; 28
Liang (B41) 2021; 30
Le Berre (B36) 2023; 402
Yang (B86) 2022; 42
Zhang (B95) 2015; 33
Xie (B81) 2021; 37
Rawat (B54) 2019; 10
Scalavino (B56) 2022; 23
Wu (B79) 2022
Tian (B69) 2019; 156
Zhu (B99)
Zuo (B102) 2016; 2016
Zhou (B98) 2021; 12
Li (B39) 2023
Sun (B62) 2024; 30
Wang (B71); 16
Na (B47) 2019; 16
Zhu (B101)
Li (B37) 2017; 2017
Kang (B32) 2023; 2023
Wang (B73) 2018
Wei (B78) 2017; 636
Friedrich (B17) 2019; 50
Tseng (B70) 2021; 24
Qu (B53) 2019; 67
Mann (B46) 2018; 9
Huang (B27) 2024
Wang (B76) 2012; 31
Zeng (B91) 2020; 64
Chen (B10) 2024; 64
Essandoh (B16) 2016; 46
Gwiggner (B21) 2018; 9
Liang (B40) 2023; 18
Jimenez (B29) 2022; 219
Zhang (B94); 55
Ai (B3) 2022; 47
Zhang (B96); 320
He (B26); 17
Alrafas (B4) 2020; 64
Laurindo (B35) 2023; 15
Rawat (B55) 2020; 159
Yang (B88) 2021; 59
Hamdan (B22) 2011; 66
Tang (B67) 2012; 22
Wang (B72) 2019; 23
Xu (B82); 13
Kimura (B34) 2005; 102
Kalantari (B31) 2017; 292
Zhao (B97) 2023
Chen (B11); 274
References_xml – volume: 102
  start-page: 17089
  year: 2005
  ident: B34
  article-title: Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT
  publication-title: Proc. Natl. Acad. Sci. U S A.
  doi: 10.1073/pnas.0508517102
– volume: 42
  start-page: 848
  year: 2017
  ident: B92
  article-title: MicroRNA-122a regulates Zonulin by targeting EGFR in intestinal epithelial dysfunction
  publication-title: Cell Physiol. Biochem.
  doi: 10.1159/000478629
– volume: 284
  start-page: 770
  year: 1999
  ident: B6
  article-title: Notch signaling: cell fate control and signal integration in development
  publication-title: Science
  doi: 10.1126/science.284.5415.770
– volume: 264
  start-page: 113243
  year: 2021
  ident: B28
  article-title: Kuijieling decoction suppresses NLRP3-Mediated pyroptosis to alleviate inflammation and experimental colitis in vivo and in vitro
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2020.113243
– volume: 30
  start-page: 174
  year: 2024
  ident: B62
  article-title: Improvement of colonic mucosa inflammatory response in mice with ulcerative colitis by Xiezhuo Jiedu recipe through miRNA-155-5p/JAK2/STAT3 pathway
  publication-title: Chin. J. Exp. Traditional Med. Formulae
  doi: 10.13422/j.cnki.syfjx.20231711
– volume: 13
  start-page: 482
  year: 2019
  ident: B15
  article-title: A molecular targeted immunotherapeutic strategy for ulcerative colitis via dual-targeting nanoparticles delivering miR-146b to intestinal macrophages
  publication-title: J. Crohns Colitis
  doi: 10.1093/ecco-jcc/jjy181
– volume: 292
  start-page: 5634
  year: 2017
  ident: B31
  article-title: miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M116.749325
– volume: 127
  start-page: 257
  year: 2010
  ident: B23
  article-title: Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer
  publication-title: Intl J. Cancer
  doi: 10.1002/ijc.25041
– volume: 55
  start-page: 4399
  ident: B94
  article-title: Effect of baicalin on liver repair after acetaminophen-induced liver injury based on mTOR signaling pathway
  publication-title: Chin. Traditional Herb. Drugs
  doi: 10.7501/j.issn.0253-2670.2024.13.012
– volume: 28
  start-page: 94
  year: 2019
  ident: B63
  article-title: Effect of Qingchang Wenzhong decoction on miR-675-5p/VDR signaling pathway in rats with DSS-induced ulcerative colitis
  publication-title: J. Emerg. Traditional Chin. Med.
  doi: 10.3969/j.issn.1004-745X.2019.01.027
– volume: 9
  start-page: 85
  year: 2018
  ident: B21
  article-title: MicroRNA-31 and MicroRNA-155 are overexpressed in ulcerative colitis and regulate IL-13 signaling by targeting interleukin 13 receptor α-1
  publication-title: Genes (Basel)
  doi: 10.3390/genes9020085
– volume: 10
  start-page: 983
  year: 2017
  ident: B58
  article-title: The signaling axis of microRNA-31/interleukin-25 regulates Th1/Th17-mediated inflammation response in colitis
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2016.102
– volume: 16
  start-page: 531
  year: 2019
  ident: B47
  article-title: Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-019-0172-4
– volume: 159
  start-page: 1375
  year: 2020
  ident: B55
  article-title: IL1B increases intestinal tight junction permeability by up-regulation of MIR200C-3p, which degrades occludin mRNA
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2020.06.038
– volume: 66
  start-page: 258
  year: 2017
  ident: B33
  article-title: Genome-wide mapping of DROSHA cleavage sites on primary MicroRNAs and noncanonical substrates
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.03.013
– volume: 24
  start-page: 1481
  year: 2018
  ident: B93
  article-title: Helicobacter pylori colonization protects against chronic experimental colitis by regulating Th17/Treg balance
  publication-title: Inflamm. Bowel. Dis.
  doi: 10.1093/ibd/izy107
– volume: 24
  year: 2024
  ident: B80
  article-title: Explore on the mechanism of miRNA-146a/TAB1 in the regulation of cellular apoptosis and inflammation in ulcerative colitis based on NF-κB pathway
  publication-title: Curr. Mol. Med.
  doi: 10.2174/0115665240273807231122052445
– volume: 636
  start-page: 23
  year: 2017
  ident: B78
  article-title: miR-130a regulates differential lipid accumulation between intramuscular and subcutaneous adipose tissues of pigs via suppressing PPARG expression
  publication-title: Gene
  doi: 10.1016/j.gene.2017.08.036
– volume: 10
  start-page: 752
  year: 2019
  ident: B54
  article-title: MicroRNA in pancreatic cancer: from biology to therapeutic potential
  publication-title: Genes (Basel)
  doi: 10.3390/genes10100752
– ident: B99
  article-title: Effect of miR-155 and compound sophorae decoction on intestinal Th17/Treg of ulcerative colitis
  publication-title: Huazhong Univ. Sci. Technol
  doi: 10.27157/d.cnki.ghzku.2020.005205
– volume: 40
  start-page: 419
  year: 2020
  ident: B61
  article-title: Effect of curcumin on inflammatory response of rats with inflammatory bowel disease by regulating expression of miR-425
  publication-title: Int. J. Dig. Dis.
  doi: 10.3969/j.issn.1673-534X.2020.06.013
– volume: 46
  start-page: 122
  year: 2016
  ident: B16
  article-title: MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response
  publication-title: Shock
  doi: 10.1097/SHK.0000000000000604
– volume: 9
  start-page: 890
  year: 2018
  ident: B45
  article-title: Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-018-0814-4
– volume: 64
  start-page: 1
  year: 2024
  ident: B10
  article-title: Based on IL - 6/STAT3 signaling pathway to explore miR - a - 5 p 34 had expressed the effect of ulcerative colitis and berberine intervention effect
  publication-title: Shandong Med. J.
  doi: 10.3969/j.issn.1002-266X.2024.01.001
– volume: 12
  start-page: 609319
  ident: B7
  article-title: JQ1 as a BRD4 inhibitor blocks inflammatory pyroptosis-related acute colon injury induced by LPS
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.609319
– volume: 2020
  start-page: 8813558
  year: 2020
  ident: B85
  article-title: The function and role of the Th17/Treg cell balance in inflammatory bowel disease
  publication-title: J. Immunol. Res.
  doi: 10.1155/2020/8813558
– volume: 25
  start-page: S129
  year: 2010
  ident: B64
  article-title: Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.2009.06216.x
– volume: 41
  start-page: 301
  year: 2022
  ident: B48
  article-title: Inflammatory bowel disease and carcinogenesis
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-022-10028-4
– volume: 11
  start-page: 01067
  year: 2020
  ident: B89
  article-title: A systematic review of the pharmacology, toxicology and pharmacokinetics of matrine
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.01067
– volume: 66
  start-page: 385
  year: 2011
  ident: B22
  article-title: Secondary metabolites of ponderosa lemon (Citrus pyriformis) and their antioxidant, anti-inflammatory, and cytotoxic activities
  publication-title: Z Naturforsch C J. Biosci.
  doi: 10.1515/znc-2011-7-810
– volume: 15
  start-page: 229
  year: 2023
  ident: B35
  article-title: Curcumin-based nanomedicines in the treatment of inflammatory and immunomodulated diseases: an evidence-based comprehensive review
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics15010229
– volume: 12
  start-page: 14966
  year: 2020
  ident: B43
  article-title: MiR-155 contributes to intestinal barrier dysfunction in DSS-induced mice colitis via targeting HIF-1α/TFF-3 axis
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.103555
– volume: 30
  start-page: 508
  year: 2022
  ident: B52
  article-title: Clinical observation of Kaixuan Decoction in treating patients withmild uleerative colitis
  publication-title: Chin. J. Integr. Traditional West. Med. Dig.
  doi: 10.3969/j.issn.1671-038X.2022.07.09
– volume: 53
  start-page: 379
  year: 2018
  ident: B2
  article-title: Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies
  publication-title: Scand. J. Gastroenterol.
  doi: 10.1080/00365521.2018.1447597
– volume: 274
  start-page: 113997
  ident: B11
  article-title: Ginsenoside Rh2 alleviates ulcerative colitis by regulating the STAT3/miR-214 signaling pathway
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2021.113997
– year: 2023
  ident: B97
  article-title: Berberine inhibits apoptosis by regulating the miR-103a-3p/BRD4 axis β-catenin pathway can inhibit cell death and intestinal mucosal barrier defects
  publication-title: Guizhou Med. Univ
  doi: 10.27045/d.cnki.ggyyc.2022.000302
– volume: 9
  start-page: 3338
  year: 2018
  ident: B46
  article-title: Author Correction: an NF-κB-microRNA regulatory network tunes macrophage inflammatory responses
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05720-5
– volume: 64
  start-page: e2000452
  year: 2020
  ident: B91
  article-title: Chlorogenic acid suppresses miR-155 and ameliorates ulcerative colitis through the NF-κB/NLRP3 inflammasome pathway
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.202000452
– volume: 64
  start-page: e1900633
  year: 2020
  ident: B4
  article-title: Resveratrol downregulates miR-31 to promote T regulatory cells during prevention of TNBS-induced colitis
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.201900633
– volume: 152
  start-page: 1434
  ident: B25
  article-title: MicroRNA 301A promotes intestinal inflammation and colitis-associated cancer development by inhibiting BTG1
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2017.01.049
– year: 2022
  ident: B79
  article-title: The study on the mechanism of overexpression of miR-146a in EVs in rats with UC and the effect of compound sophorae decoction on intestinal barrier function via Notch signaling
  publication-title: Huazhong Univ. Sci. & Technol
  doi: 10.27157/d.cnki.ghzku.2020.000606
– volume: 117
  start-page: 19408
  year: 2020
  ident: B14
  article-title: CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: effector resistance to immune suppression
  publication-title: Proc. Natl. Acad. Sci. U S A.
  doi: 10.1073/pnas.2005010117
– volume: 16
  start-page: 19
  year: 2019
  ident: B18
  article-title: Tales from the crypt: new insights into intestinal stem cells
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-018-0081-y
– volume: 32
  start-page: 557
  year: 2010
  ident: B60
  article-title: E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.03.017
– volume: 488
  start-page: 6
  year: 2017
  ident: B83
  article-title: MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2017.04.143
– volume: 13
  start-page: 303
  year: 2020
  ident: B59
  article-title: MicroRNA-219a-5p suppresses intestinal inflammation through inhibiting Th1/Th17-mediated immune responses in inflammatory bowel disease
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-019-0216-7
– volume: 22
  start-page: 504
  year: 2012
  ident: B67
  article-title: Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system
  publication-title: Cell Res.
  doi: 10.1038/cr.2011.137
– volume: 126
  start-page: 109909
  year: 2020
  ident: B100
  article-title: miR-155 antagomir protect against DSS-induced colitis in mice through regulating Th17/Treg cell balance by Jarid2/Wnt/β-catenin
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2020.109909
– volume: 13
  start-page: 871713
  year: 2022
  ident: B5
  article-title: The role of intestinal mucosal barrier in Autoimmune disease: a potential target
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.871713
– volume: 37
  start-page: 1573
  year: 2021
  ident: B81
  article-title: Naringenin inhibits NLRP3 inflammasome through miR-22 and reduces intestinal barrier damage in a rat model of ulcerative colitis
  publication-title: Chin. J. Pathophysiol.
  doi: 10.3969/j.issn.1000-4718.2021.09.005
– volume: 32
  start-page: 1065
  year: 2016
  ident: B8
  article-title: Advances in the regulation of T cell differentiation and function by miR-155
  publication-title: Chin. J. Immunol.
  doi: 10.3969/j.issn.1000-484X.2016.07.031
– volume: 59
  start-page: 97
  year: 2021
  ident: B88
  article-title: Artesunate alleviates the inflammatory response of ulcerative colitis by regulating the expression of miR-155
  publication-title: Pharm. Biol.
  doi: 10.1080/13880209.2020.1867196
– volume: 526
  start-page: 1157
  year: 2020
  ident: B9
  article-title: miR-340 affects sauchinone inhibition of Th17 cell differentiation and promotes intestinal inflammation in inflammatory bowel disease
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2020.04.038
– volume: 156
  start-page: 2281
  year: 2019
  ident: B69
  article-title: MicroRNA-31 reduces inflammatory signaling and promotes regeneration in colon epithelium, and delivery of mimics in microspheres reduces colitis in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.02.023
– ident: B101
  article-title: Study on the regulatory effect and mechanism of ShenlingBaizhu powder on intestinal mucosal barrier inUlcerative colitis through MiR-130a/PPARγ/OccludinPathway
  publication-title: Shandong Univ. Traditional Chin. Med
  doi: 10.27282/d.cnki.gsdzu.2022.000966
– volume: 11
  start-page: 625
  year: 2020
  ident: B49
  article-title: MicroRNA-155 implication in M1 polarization and the impact in inflammatory diseases
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.00625
– volume: 402
  start-page: 571
  year: 2023
  ident: B36
  article-title: Ulcerative colitis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(23)00966-2
– volume: 34
  start-page: 831
  year: 2023
  ident: B90
  article-title: Matrine protects intestinal barrier function via MicroRNA-155 through ROCK1-signaling pathway
  publication-title: Turk J. Gastroenterol.
  doi: 10.5152/tjg.2023.21884
– volume: 45
  start-page: 1254
  year: 2022
  ident: B20
  article-title: Human breast milk-derived exosomal miR-148a-3p protects against necrotizing enterocolitis by regulating p53 and sirtuin 1
  publication-title: Inflammation
  doi: 10.1007/s10753-021-01618-5
– volume: 33
  start-page: 235
  year: 2015
  ident: B95
  article-title: MicroRNA-21 regulates intestinal epithelial tight junction permeability
  publication-title: Cell Biochem. Funct.
  doi: 10.1002/cbf.3109
– volume: 50
  start-page: 992
  year: 2019
  ident: B17
  article-title: Cytokine networks in the pathophysiology of inflammatory bowel disease
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.017
– volume: 42
  start-page: 1517
  year: 2022
  ident: B86
  article-title: Effects of Qingchang Huayu recipe on CDX2 mRNA, miR-22 and Th17 cells in patients with ulcerative colitis
  publication-title: J. Hunan Univ. Chin. Med.
  doi: 10.3969/j.issn.1674-070X.2022.09.016
– volume: 28
  start-page: 153
  year: 2022
  ident: B51
  article-title: Research progress on the antitumor mechanism of icariin
  publication-title: Guid. J. Traditional Chin. Med. Pharm.
  doi: 10.13862/j.cn43-1446/r.2022.08.034
– volume: 214
  start-page: 151
  year: 2018
  ident: B13
  article-title: Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK/STAT3 signaling pathway in a mouse model of ulcerative colitis
  publication-title: Pathol. Res. Pract.
  doi: 10.1016/j.prp.2017.10.003
– volume: 2023
  start-page: 2457006
  year: 2023
  ident: B32
  article-title: MicroRNA-22 regulates the pro-inflammatory responses and M1 polarization of macrophages by targeting GLUT1 and 4-1BBL
  publication-title: J. Immunol. Res.
  doi: 10.1155/2023/2457006
– volume: 12
  start-page: 707776
  year: 2021
  ident: B98
  article-title: miRNA-based potential biomarkers and new molecular insights in ulcerative colitis
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2021.707776
– volume: 30
  start-page: 1
  year: 2018
  ident: B68
  article-title: Immune response and inflammatory pathway of ulcerative colitis
  publication-title: J. Basic Clin. Physiol. Pharmacol.
  doi: 10.1515/jbcpp-2018-0036
– volume: 36
  start-page: 3240
  year: 2017
  ident: B75
  article-title: miR-19a promotes colitis-associated colorectal cancer by regulating tumor necrosis factor alpha-induced protein 3-NF-κB feedback loops
  publication-title: Oncogene
  doi: 10.1038/onc.2016.468
– volume: 23
  start-page: 5840
  year: 2022
  ident: B56
  article-title: The increase of miR-195-5p reduces intestinal permeability in ulcerative colitis, modulating tight junctions’ expression
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms23105840
– volume: 46
  start-page: 9134
  year: 2018
  ident: B65
  article-title: LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky575
– year: 2024
  ident: B27
  article-title: Mechanism of Sishen pills treated UC by regulating inflammatory differentiation of Dendritic Cells via miR-505-3p
  publication-title: Jiangxi Univ. Chin. Med
  doi: 10.27180/d.cnki.gjxzc.2023.000636
– volume: 219
  start-page: e20212278
  year: 2022
  ident: B29
  article-title: The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20212278
– volume: 17
  start-page: 2112
  year: 2021
  ident: B30
  article-title: Roles of microRNAs in inflammatory bowel disease
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.59904
– volume: 11
  start-page: 46
  year: 2018
  ident: B1
  article-title: JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling
  publication-title: Epigenetics Chromatin
  doi: 10.1186/s13072-018-0217-x
– volume: 36
  start-page: e24455
  year: 2022
  ident: B57
  article-title: Dioscin ameliorates inflammatory bowel disease by up-regulating miR-125a-5p to regulate macrophage polarization
  publication-title: J. Clin. Lab. Anal.
  doi: 10.1002/jcla.24455
– volume: 2017
  start-page: 8524972
  year: 2017
  ident: B37
  article-title: Downregulation of miR-214-3p may contribute to pathogenesis of ulcerative colitis via targeting STAT6
  publication-title: Biomed. Res. Int.
  doi: 10.1155/2017/8524972
– volume: 47
  start-page: 5797
  year: 2022
  ident: B3
  article-title: Review of classical prescriptions in treatment of ulcerative colitis
  publication-title: China J. Chin. Materia Medica
  doi: 10.19540/j.cnki.cjcmm.20220713.501
– volume: 21
  start-page: 41
  year: 2022
  ident: B12
  article-title: Clinical observation on treatment of ulcerative colitis with Qixianyijiang decoction combined with Chinese herbal enema
  publication-title: Chin. J. Difficult Complicat. Cases
  doi: 10.3969/j.issn.1671-6450.2022.01.008
– volume: 16
  start-page: 2305
  ident: B71
  article-title: Diosgenin and its analogs: potential protective agents against atherosclerosis
  publication-title: Drug Des. Devel Ther.
  doi: 10.2147/DDDT.S368836
– volume: 19
  start-page: 981
  year: 2020
  ident: B44
  article-title: The role of the miR-21-5p-mediated inflammatory pathway in ulcerative colitis
  publication-title: Exp. Ther. Med.
  doi: 10.3892/etm.2019.8277
– volume: 13
  start-page: 855645
  ident: B82
  article-title: Identification of immune-related gene signature and prediction of CeRNA network in active ulcerative colitis
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.855645
– volume: 17
  start-page: 2317
  year: 2022
  ident: B19
  article-title: Protective mechanism of Gegen Qinlian decoction against ulcerative colitis by regulating MicroRNA-542-3p
  publication-title: World Chin. Med.
  doi: 10.3969/j.issn.1673-7202.2022.16.016
– volume: 45
  start-page: 2393
  year: 2023
  ident: B87
  article-title: The impact of Jiuwei Baizhu decoction on the intestinal mucosal immune barrier and miR-155/SOCS-1 Axis in acute ulcerative colitis rats
  publication-title: Chin. Tradit. Pat. Med.
  doi: 10.3969/j.issn.1001-1528.2023.07.050
– volume: 320
  start-page: 117419
  ident: B96
  article-title: Lycibarbarspermidine L from the fruit of Lycium barbarum L. recovers intestinal barrier damage via regulating miR-195-3p
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2023.117419
– volume: 37
  start-page: e23245
  year: 2023
  ident: B38
  article-title: MicroRNA-9a-5p-NOX4 inhibits intestinal inflammatory injury by regulating the M1 polarization of intestinal macrophages
  publication-title: J. Biochem. Mol. Toxicol.
  doi: 10.1002/jbt.23245
– volume: 18
  start-page: 2799
  year: 2023
  ident: B40
  article-title: HucMSC-exo promote mucosal healing in experimental colitis by accelerating intestinal stem cells and epithelium regeneration via Wnt signaling pathway
  publication-title: Int. J. Nanomedicine
  doi: 10.2147/IJN.S402179
– volume: 360
  start-page: 74
  year: 2017
  ident: B66
  article-title: MicroRNA-29a regulates lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages through the Akt1/NF-κB pathway
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2017.08.013
– volume: 65
  start-page: 1938
  year: 2016
  ident: B24
  article-title: miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-309389
– volume: 24
  start-page: 71
  year: 2021
  ident: B70
  article-title: Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death
  publication-title: Nutr. Neurosci.
  doi: 10.1080/1028415X.2019.1594554
– volume: 320
  start-page: 117413
  year: 2024
  ident: B77
  article-title: Curcumin promotes renewal of intestinal epithelium by miR-195-3p
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2023.117413
– year: 2018
  ident: B73
  article-title: Baicalin protects against TNF-a-induced injury byregulating microRNA in lEC-6 cells
  publication-title: Guangzhou Univ. Chin. Med
– volume: 30
  start-page: 1717
  year: 2021
  ident: B41
  article-title: Effect of Anchang Decoction on mir NA-146a/IRAK-1/NF-κB signaling pathway in rats with ulcerative colitis of body resistance weakened while pathogenic factors protracted
  publication-title: Mod. J. Integr. Traditional Chin. West. Med.
  doi: 10.3969/j.issn.1008-8849.2021.16.002
– volume: 31
  start-page: 951
  year: 2012
  ident: B76
  article-title: N-3 PUFAs attenuate ischemia/reperfusion induced intestinal barrier injury by activating I-FABP-PPARγ pathway
  publication-title: Clin. Nutr.
  doi: 10.1016/j.clnu.2012.03.003
– volume: 2022
  start-page: 1755608
  ident: B74
  article-title: Honokiol ameliorates DSS-induced mouse colitis by inhibiting inflammation and oxidative stress and improving the intestinal barrier
  publication-title: Oxid. Med. Cell Longev.
  doi: 10.1155/2022/1755608
– volume: 17
  start-page: 400
  ident: B26
  article-title: Clinical significances of plasma diamineoxidase. D ⁃ lactate and endotoxin activity in critical ill patient with gastrointestinal dysfunction
  publication-title: Lingnan Mod. Clin. Surg.
  doi: 10.3969/j.issn.1009-976X.2017.04.005
– volume: 67
  start-page: 22
  year: 2019
  ident: B53
  article-title: Suppression of miR-21 and miR-155 of macrophage by cinnamaldehyde ameliorates ulcerative colitis
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2018.11.045
– volume: 23
  start-page: 2151
  year: 2019
  ident: B72
  article-title: MiR-146a regulates the development of ulcerative colitis via mediating the TLR4/MyD88/NF-κB signaling pathway
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
  doi: 10.26355/eurrev_201903_17260
– volume: 2016
  start-page: 1489050
  year: 2016
  ident: B102
  article-title: The potential therapeutic effects of artesunate on stroke and other central nervous system diseases
  publication-title: Biomed. Res. Int.
  doi: 10.1155/2016/1489050
– volume: 114
  start-page: 110360
  ident: B84
  article-title: MicroRNA-182-5p aggravates ulcerative colitis by inactivating the Wnt/β-catenin signaling pathway through DNMT3A-mediated SMARCA5 methylation
  publication-title: Genomics
  doi: 10.1016/j.ygeno.2022.110360
– volume: 75
  start-page: 105768
  year: 2019
  ident: B42
  article-title: Limonin ameliorates ulcerative colitis by regulating STAT3/miR-214 signaling pathway
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2019.105768
– year: 2023
  ident: B39
  article-title: Effect of icariin on TNF-α-induced destruction of tight junctions of Occludin in intestinal epithelial cells mediated by miR-122a
  publication-title: China Three Gorges Univ
  doi: 10.27270/d.cnki.gsxau.2022.000382
– volume: 67
  start-page: 157
  year: 2020
  ident: B50
  article-title: MiR-98-5p expression inhibits polarization of macrophages to an M2 phenotype by targeting Trib1 in inflammatory bowel disease
  publication-title: Acta Biochim. Pol.
  doi: 10.18388/abp.2020_5152
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Snippet This review presents the progress of traditional Chinese medicines in the treatment of ulcerative colitis by regulating miRNAs. Ulcerative colitis (UC) is a...
Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease whose pathogenesis remains unclear. Dysfunction of the intestinal mucosal barrier...
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StartPage 1446554
SubjectTerms intestinal mucosal barrier
mechanism of action
MicroRNAs
traditional Chinese medicine
ulcerative colitis
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Title MiRNAs: a new target for Chinese medicine to repair the intestinal barrier in the treatment of ulcerative colitis
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Volume 15
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