Mycobacterium tuberculosis Induces Differential Cytokine Production from Dendritic Cells and Macrophages with Divergent Effects on Naive T Cell Polarization

• Published in: The Journal of immunology (1950) Vol. 168; no. 9; pp. 4636 - 4642
• Main Authors: Hickman, Somia Perdow, Chan, John, Salgame, Padmini
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.05.2002
• Subjects: Animals; Cells, Cultured; Cytokines - biosynthesis; Dendritic Cells - immunology; Dendritic Cells - microbiology; Female; Genes, T-Cell Receptor; Interferon-gamma - pharmacology; Interleukin-10 - genetics; Interleukin-10 - physiology; Interleukin-12 - biosynthesis; Macrophages - immunology; Macrophages - microbiology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Transgenic; Mycobacterium tuberculosis; Mycobacterium tuberculosis - pathogenicity; T-Lymphocytes - immunology; Th1 Cells - immunology

Th1-mediated cellular responses are important for protection in tuberculosis. However, the mechanisms and APC types responsible for initiating Th1 responses are not well understood. These studies show that macrophages and dendritic cells, albeit both being APC, respond differently following Mycobact...