Condensation of acrylonitrile and aryl acetonitrile: construction of α-amino-β-cyano cyclohexene skeletons

• Published in: RSC advances Vol. 12; no. 46; pp. 2984 - 29843
• Main Authors: Zhang, Wei, Tang, Chuan-Su, Xiang, Shi-Qun
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 18.10.2022; The Royal Society of Chemistry
• Subjects: Acetonitrile; Aromatic compounds; Chemistry; Cyclohexene; Room temperature

A representative condensation of acrylonitrile and aryl acetonitrile has been reported for the synthesis of α-amino-β-cyano cyclohexene. The reaction was carried out mildly in an open environment at room temperature. The scope and versatility of the method have been demonstrated with 20 examples, co...