The good, the bad, and the unknown nature of decreased GD3 synthase expression

• Published in: Frontiers in molecular neuroscience Vol. 17; p. 1465013
• Main Authors: Puljko, Borna, Grbavac, Josip, Potočki, Vinka, Ilic, Katarina, Viljetić, Barbara, Kalanj-Bognar, Svjetlana, Heffer, Marija, Debeljak, Željko, Blažetić, Senka, Mlinac-Jerkovic, Kristina
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2024
• Subjects: gangliosides; glycosphingolipids; lipid metabolism; lipidomics; ST8SIA1; gangliosides; ST8SIA1; lipidomics; glycosphingolipids; lipid metabolism

This paper explores the physiological consequences of decreased expression of GD3 synthase (GD3S), a biosynthetic enzyme that catalyzes the synthesis of b-series gangliosides. GD3S is a key factor in tumorigenesis, with overexpression enhancing tumor growth, proliferation, and metastasis in various...