Overflow metabolism originates from growth optimization and cell heterogeneity - Wang, Xin (eLife, 2025)
Keywords: aerobic glycolysis; Biomass; Biosynthesis; Cancer; Carbon; Cell growth; cell heterogeneity; Cell Proliferation; Computational and Systems Biology; E coli; Energy consumption; Energy Metabolism; Enzyme kinetics; Escherichia coli - growth & development; Escherichia coli - metabolism; Fermentation; metabolic strategy; Metabolism; Metabolites; Models, Biological; overflow metabolism; Oxygen - metabolism; Physics of Living Systems; Proteins; Respiration; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae - metabolism; warburg effect; computational biology; systems biology; mouse; cell heterogeneity; I. orientalis; overflow metabolism; warburg effect; metabolic strategy; aerobic glycolysis; physics of living systems; E. coli; S. cerevisiae