Predicting Consanguinity Rates from Exome Sequencing Data in the Lebanese Population

• Published in: The Journal of molecular diagnostics : JMD Vol. 27; no. 3; pp. 177 - 183
• Main Authors: Hanna, Eileen Marie, Mehawej, Cybel, Assy, Joelle, Corbani, Sandra, Korban, Rima, Megarbane, Andre, Chouery, Eliane
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2025
• Subjects: Consanguinity; Exome; Exome Sequencing - methods; Female; Homozygote; Humans; Lebanon; Male; Pedigree; Lebanon

Consanguinity, prevalent in certain populations because of cultural and social factors, significantly increases the risk of genetic autosomal recessive disorders. In Lebanon, consanguineous marriages constitute 35.5% of unions, with first cousin marriages being the most common. This study aims to de...