Na-K-ATPase regulates intercellular communication in the vascular wall via cSrc kinase-dependent connexin43 phosphorylation

• Published in: American Journal of Physiology: Cell Physiology Vol. 312; no. 4; pp. C385 - C397
• Main Authors: Hangaard, Lise, Bouzinova, Elena V, Staehr, Christian, Dam, Vibeke S, Kim, Sukhan, Xie, Zijian, Aalkjaer, Christian, Matchkov, Vladimir V
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.04.2017
• Subjects: Adenosine triphosphatase; Animals; Biological Clocks - physiology; Calcium; Calcium Signaling - physiology; Cell Communication - physiology; Cells; Connexin 43 - metabolism; Gene Expression Regulation, Enzymologic - physiology; Mesenteric Arteries - physiology; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - physiology; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - physiology; Phosphorylation; Rats; Smooth muscle; Sodium-Potassium-Exchanging ATPase - metabolism; src-Family Kinases - metabolism; Na-K-ATPase; vasomotion; cSrc kinase signaling; gap junctions; artery

Communication between vascular smooth muscle cells (VSMCs) is dependent on gap junctions and is regulated by the Na-K-ATPase. The Na-K-ATPase is therefore important for synchronized VSMC oscillatory activity, i.e., vasomotion. The signaling between the Na-K-ATPase and gap junctions is unknown. We te...