Exploring NK cell dynamics and the CD47-SIRPα axis in colon cancer

• Published in: Human immunology Vol. 86; no. 2; p. 111254
• Main Authors: Yilmaz, Latif, Oztuzcu, Serdar, Eronat, Omer, Ugur, Berna Kaya, Gumus, Mahmut, Guler, Semih, Tasdemir, Demet, Bozgeyik, Esra, Caska, Halil, Bozgeyik, Ibrahim
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2025
• Subjects: Aged; Antigens, Differentiation - metabolism; CD47; CD47 Antigen - immunology; CD47 Antigen - metabolism; Colon cancer; Colonic Neoplasms - immunology; Colonic Neoplasms - metabolism; Colonic Neoplasms - surgery; Female; Humans; IFNγ; Interferon-gamma - metabolism; Killer Cells, Natural - immunology; Male; Middle Aged; NK cells; Receptors, Immunologic - metabolism; SIRPα; IFNγ; SIRPα; NK cells; Colon cancer; CD47

Inhibitory therapy targeting immune checkpoint regulators, specifically the SIRPα/CD47 axis, has emerged as a promising approach for cancer immunotherapy. SIRPα, which is predominantly expressed in neurons, dendritic cells, macrophages, and NK cells, inhibits professional phagocytes, primarily macro...