Integrating genomics and AI to uncover molecular targets for mRNA vaccine development in lupus nephritis

• Published in: Frontiers in immunology Vol. 15; p. 1381445
• Main Authors: Mou, Lisha, Lu, Ying, Wu, Zijing, Pu, Zuhui, Wang, Meiying
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2024
• Subjects: Adult; Artificial Intelligence; Female; Gene Expression Profiling; genomics; Genomics - methods; Humans; lupus nephritis; Lupus Nephritis - genetics; Lupus Nephritis - immunology; Machine Learning; Male; mRNA Vaccines; non-negative matrix factorization (NMF); RNA, Messenger - genetics; single cell; Single-Cell Analysis; single-cell RNA sequencing; systemic lupus erythematosus; Transcriptome; Vaccine Development; single-cell RNA sequencing; single cell; systemic lupus erythematosus; non-negative matrix factorization (NMF); genomics; lupus nephritis; machine learning; functional network analysis

Lupus nephritis (LN), a complex complication of systemic lupus erythematosus, requires in-depth cellular and molecular analysis for advanced treatment strategies, including mRNA vaccine development. In this study, we analyzed single-cell RNA sequencing data from 24 LN patients and 10 healthy control...