Inhibitor of Apoptosis Protein from Orgyia pseudotsugata Nuclear Polyhedrosis Virus Provides a Costimulatory Signal Required for Optimal Proliferation of Developing Thymocytes

The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development a...

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Published inThe Journal of immunology (1950) Vol. 168; no. 4; pp. 1770 - 1779
Main Authors Robles, Maria S, Leonardo, Esther, Criado, Luis Miguel, Izquierdo, Manuel, Martinez-A., Carlos
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 15.02.2002
Subjects
Animals
Apoptosis
Baculovirus
CD3 Complex - metabolism
Cells, Cultured
Cytokines - biosynthesis
DNA-Binding Proteins - metabolism
I-kappa B Proteins
I^KB^a protein
IAP protein
IBa protein
Inhibitor of Apoptosis Proteins
Lymphocyte Activation
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics
Mice
Mice, Transgenic
NF-kappa B - metabolism
NF-KappaB Inhibitor alpha
Nuclear polyhedrosis virus
Nucleopolyhedrovirus
Orgyia pseudotsugata
Promoter Regions, Genetic
Proteins - genetics
Receptors, Antigen, T-Cell - antagonists & inhibitors
Receptors, Antigen, T-Cell - metabolism
Signal Transduction
T-Lymphocytes - immunology
Thymus Gland - growth & development
Thymus Gland - immunology
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Abstract The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development and homeostasis, we generated transgenic mice expressing IAP generated from the baculovirus Orgyia pseudotsugata nuclear polyhedrosis virus (OpIAP). Developing thymocytes expressing OpIAP show increased nuclear levels of NF-kappaB and reduced cytoplasmic levels of its inhibitor, IkappaBalpha. In mature thymocytes, OpIAP induces optimal activation and proliferation after TCR triggering in the absence of a costimulatory signal. OpIAP expression in immature thymocytes blocks TCR-induced apoptosis. Taken together, our data illustrate the pleiotropism of OpIAP in vivo.
AbstractList The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development and homeostasis, we generated transgenic mice expressing IAP generated from the baculovirus Orgyia pseudotsugata nuclear polyhedrosis virus (OpIAP). Developing thymocytes expressing OpIAP show increased nuclear levels of NF-kappaB and reduced cytoplasmic levels of its inhibitor, IkappaBalpha. In mature thymocytes, OpIAP induces optimal activation and proliferation after TCR triggering in the absence of a costimulatory signal. OpIAP expression in immature thymocytes blocks TCR-induced apoptosis. Taken together, our data illustrate the pleiotropism of OpIAP in vivo.
Abstract The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development and homeostasis, we generated transgenic mice expressing IAP generated from the baculovirus Orgyia pseudotsugata nuclear polyhedrosis virus (OpIAP). Developing thymocytes expressing OpIAP show increased nuclear levels of NF-κB and reduced cytoplasmic levels of its inhibitor, IκBα. In mature thymocytes, OpIAP induces optimal activation and proliferation after TCR triggering in the absence of a costimulatory signal. OpIAP expression in immature thymocytes blocks TCR-induced apoptosis. Taken together, our data illustrate the pleiotropism of OpIAP in vivo.
The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development and homeostasis, we generated transgenic mice expressing IAP generated from the baculovirus Orgyia pseudotsugata nuclear polyhedrosis virus (OpIAP). Developing thymocytes expressing OpIAP show increased nuclear levels of NF- Kappa B and reduced cytoplasmic levels of its inhibitor, I Kappa B alpha . In mature thymocytes, OpIAP induces optimal activation and proliferation after TCR triggering in the absence of a costimulatory signal. OpIAP expression in immature thymocytes blocks TCR-induced apoptosis. Taken together, our data illustrate the pleiotropism of OpIAP in vivo.
Author Martinez-A., Carlos
Leonardo, Esther
Robles, Maria S
Criado, Luis Miguel
Izquierdo, Manuel
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Snippet The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing...
Abstract The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase...
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StartPage 1770
SubjectTerms Animals
Apoptosis
Baculovirus
CD3 Complex - metabolism
Cells, Cultured
Cytokines - biosynthesis
DNA-Binding Proteins - metabolism
I-kappa B Proteins
I^KB^a protein
IAP protein
IBa protein
Inhibitor of Apoptosis Proteins
Lymphocyte Activation
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics
Mice
Mice, Transgenic
NF-kappa B - metabolism
NF-KappaB Inhibitor alpha
Nuclear polyhedrosis virus
Nucleopolyhedrovirus
Orgyia pseudotsugata
Promoter Regions, Genetic
Proteins - genetics
Receptors, Antigen, T-Cell - antagonists & inhibitors
Receptors, Antigen, T-Cell - metabolism
Signal Transduction
T-Lymphocytes - immunology
Thymus Gland - growth & development
Thymus Gland - immunology
Title Inhibitor of Apoptosis Protein from Orgyia pseudotsugata Nuclear Polyhedrosis Virus Provides a Costimulatory Signal Required for Optimal Proliferation of Developing Thymocytes
URI http://www.jimmunol.org/cgi/content/abstract/168/4/1770
https://www.ncbi.nlm.nih.gov/pubmed/11823509
https://search.proquest.com/docview/18244872
https://search.proquest.com/docview/71437694
Volume 168
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