A Complex of Cirsium japonicum var. maackii (Maxim.) Matisum. and Thymus vulgaris L. Improves Menopausal Symptoms and Supports Healthy Aging in Women

• Published in: Journal of medicinal food Vol. 25; no. 3; p. 281
• Main Authors: Noh, Yoo-Hun, Hong, Junkee, Lee, Ji-Won, Kim, Sung-Su, Lee, Jun Young, Kang, Il-Jun, Won, Moo-Ho, Jeong, Yoonhwa, Whang, Wan Kyunn, Myung, Soon-Chul, Han, Seung-Su
• Format: Journal Article
• Language: English
• Published: United States 01.03.2022
• Subjects: Cirsium; Female; Healthy Aging; Hot Flashes; Humans; Menopause; Quality of Life; Thymus Plant; cortisol; bone; ET-1; menopause; KI; MenQoL
• DOI: 10.1089/jmf.2021.K.0127

We evaluated the efficacy and safety of MS-10 for the treatment of menopausal symptoms. A double-blind randomized placebo-controlled clinical trial was performed in 71 premenopausal women for 4 and 12 weeks. A total of 12 individual menopausal symptom scores were assessed using the Kupperman index. MS-10 treatment effectively improved the symptoms by ∼48%. In addition, the quality of life of the women improved by 36% from four perspectives: vasomotor, psychosocial, physical, and sexual symptoms as evaluated using the menopause-specific quality of life (MenQoL) questionnaire. Our results show that MS-10 improves insulin-like growth factor-1 (IGF-1) and estrogen utilization through receptor activation, which are thought to have causative therapeutic effects on menopause and aging inhibition in women. Improvement of Enthotheline-1 (ET-1) in the blood after MS-10 intake led to an improvement in menopausal vascular symptoms. Improvements in bone formation and absorption markers such as osteocalcin, bone-specific alkaline phosphatase (BSALP), C-telopeptides of type I collagen (CTx), deoxypyridinoline (deoxyPYD), and N-telopeptides of type I collagen (NTx) in blood or urine indicate that MS-10 fundamentally improves bone health in women. By confirming the improvement of the psychological well-being index based on the improvement of stress hormone cortisol, MS-10 can solve causative psychological and physical stress-related symptoms. Moreover, various safety tests, such as those for female hormones, were confirmed. Therefore, it can be confirmed that MS-10 is a natural pharmaconutraceutical that causatively and safely improves health of women and aids in antiaging processes.