Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study

• Published in: Diabetes (New York, N.Y.) Vol. 73; no. 6; pp. 983 - 992
• Main Authors: Peschard, Simon, Raverdy, Violeta, Bauvin, Pierre, Goutchtat, Rebecca, Touche, Veronique, Derudas, Bruno, Gheeraert, Celine, Dubois-Chevalier, Julie, Caiazzo, Robert, Baud, Gregory, Marciniak, Camille, Verkindt, Helene, Oukhouya Daoud, Naima, Le Roux, Carel W., Lefebvre, Philippe, Staels, Bart, Lestavel, Sophie, Pattou, François
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.06.2024
• Subjects: Biopsy; Blood glucose; Diabetes; Diabetes mellitus (non-insulin dependent); Genetic analysis; Genetics/Genomes/Proteomics/Metabolomics; Genotyping; Glucose; Glucose tolerance; Haplotypes; Intestine; Risk factors; Sodium-glucose cotransporter; Statistical analysis

The post-prandial glucose response is an independent risk factor for type 2 diabetes. Observationally, early glucose response after an oral glucose challenge has been linked to intestinal glucose absorption, largely influenced by the expression of sodium-glucose-co-transporter-1 (SGLT1). This study...