MAFB modulates the maturation of lymphatic vascular networks in mice

• Published in: Developmental dynamics Vol. 249; no. 10; pp. 1201 - 1216
• Main Authors: Rondon‐Galeano, Maria, Skoczylas, Renae, Bower, Neil I., Simons, Cas, Gordon, Emma, Francois, Mathias, Koltowska, Katarzyna, Hogan, Benjamin M.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2020; Wiley Subscription Services, Inc
• Subjects: Cell differentiation; Cell migration; CRISPR; Cyanosis; Dermis; development; Diaphragm; Embryos; Endothelial cells; Genetic modification; Genome editing; Homeostasis; Immune system; Lethality; lymphangiogenesis; lymphatic; Lymphatic system; MAFB; Maturation; Morphogenesis; Muscles; Mutants; Network formation; Redundancy; Rodents; Smooth muscle; Transcription factors; vascular; Vascular endothelial growth factor receptors; Veins & arteries; lymphangiogenesis; development; MAFB; vascular; lymphatic

Background Lymphatic vessels play key roles in tissue fluid homeostasis, immune cell trafficking and in diverse disease settings. Lymphangiogenesis requires lymphatic endothelial cell (LEC) differentiation, proliferation, migration, and co‐ordinated network formation, yet the transcriptional regulat...