Changes in serum and hepatic cholesterol in lead-induced liver hyperplasia

Lead nitrate when injected intravenously as a single dose to male Wistar rats causes a strong hepatic proliferative response followed by reabsorption of excess tissue within 10-14 days. The rate of cell proliferation in this hyperplastic model was positively correlated with hepatic de novo synthesis...

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Bibliographic Details
Published inToxicologic pathology Vol. 12; no. 2; p. 162
Main Authors Pani, P, Dessi, S, Rao, K N, Batetta, B, Laconi, E
Format Journal Article
LanguageEnglish
Published United States 01.02.1984
Subjects
Animals
Cell Division - drug effects
Cholesterol - blood
Glucosephosphate Dehydrogenase - biosynthesis
Hyperplasia - blood
Hyperplasia - chemically induced
Injections, Intravenous
Lead - administration & dosage
Lead - toxicity
Lead Poisoning - blood
Lead Poisoning - pathology
Liver - drug effects
Liver - metabolism
Liver - pathology
Male
Organ Size - drug effects
Phosphatidylcholine-Sterol O-Acyltransferase - biosynthesis
Rats
Rats, Wistar
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Summary:Lead nitrate when injected intravenously as a single dose to male Wistar rats causes a strong hepatic proliferative response followed by reabsorption of excess tissue within 10-14 days. The rate of cell proliferation in this hyperplastic model was positively correlated with hepatic de novo synthesis of cholesterol, stimulation of the hexose monophosphate shunt pathway of glucose metabolism and with alterations in serum lipoproteins.
ISSN:0192-6233
1533-1601
DOI:10.1177/019262338401200208