Platelet-Rich Plasma Influences Expansion and Paracrine Function of Adipose-Derived Stromal Cells in a Dose-Dependent Fashion

• Published in: Plastic and reconstructive surgery (1963) Vol. 137; no. 3; p. 554e
• Main Authors: Willemsen, Joep C N, Spiekman, Maroesjka, Stevens, H P Jeroen, van der Lei, Berend, Harmsen, Martin C
• Format: Journal Article
• Language: English
• Published: United States 01.03.2016
• Subjects: Adipocytes - cytology; Adipocytes - physiology; Animals; Cattle; Cell Culture Techniques; Cell Proliferation - physiology; Cells, Cultured; Collagen Type I - genetics; Culture Media, Conditioned; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Mesenchymal Stem Cells - cytology; Paracrine Communication; Platelet-Rich Plasma; Real-Time Polymerase Chain Reaction - methods; Sensitivity and Specificity

Lipofilling is a treatment modality to restore tissue volume. Both platelet-rich plasma and adipose-derived stromal cells have been reported to augment the efficacy of lipofilling, yet results are not conclusive. The authors hypothesized that the variation reported in literature is caused by a dose-...