Tigecycline and Gentamicin-Combined Treatment Enhances Renal Damage: Oxidative Stress, Inflammatory Reaction, and Apoptosis Interplay

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 6; p. 736
• Main Authors: Elgazzar, Dina, Aboubakr, Mohamed, Bayoumi, Heba, Ibrahim, Amany N., Sorour, Safwa M., El-Hewaity, Mohamed, Elsayed, Abulmaaty M., Shehata, Shaimaa A., Bayoumi, Khaled A., Alsieni, Mohammed, Behery, Maged, Abdelrahaman, Doaa, Ibrahim, Samah F., Abdeen, Ahmed
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 10.06.2022; MDPI
• Subjects: aminoglycosides; Animals; annexin-V; Antibiotics; Apoptosis; Cell cycle; Creatinine; Infections; inflammatory cytokines; kidney injury; Microorganisms; oxidative damage; Oxidative stress; Pathogens; Protein expression; tetracyclines

Although the combination of antibiotics is generally well-tolerated, they may have nephrotoxic effects. This study investigated whether tigecycline (TG) and gentamicin (GM) co-administration could accelerate renal damage. Male Wistar rats were randomly divided into six experimental groups: the contr...