"Discordant" increases in CD4 cell count relative to plasma viral load in a closely followed cohort of patients initiating antiretroviral therapy

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 30; no. 2; p. 159
• Main Authors: Wood, Evan, Hogg, Robert S, Yip, Benita, Tyndall, Mark W, Sherlock, Christopher H, Harrigan, Richard P, O'Shaughnessy, Michael V, Montaner, Julio S G
• Format: Journal Article
• Language: English
• Published: United States 01.06.2002
• Subjects: Adult; Anti-HIV Agents - therapeutic use; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV Infections - immunology; HIV Infections - virology; HIV Protease Inhibitors - therapeutic use; HIV-1 - physiology; Humans; Male; Middle Aged; Population Surveillance; Reverse Transcriptase Inhibitors - therapeutic use; RNA, Viral - blood; Viral Load; Viremia

In HIV-positive persons receiving antiretroviral therapy, CD4 cell responses are associated with optimal suppression of viral replication. However, increases in CD4 cell counts in the absence of viral suppression have been reported. We characterized plasma viral load (pVL) and CD4 cell count increas...