TRIM10 binds to IFN‐α/β receptor 1 to negatively regulate type I IFN signal transduction

• Published in: European journal of immunology Vol. 51; no. 7; pp. 1762 - 1773
• Main Authors: Guo, Mengmeng, Cao, Wenyan, Chen, Shengwen, Tian, Renyun, Wang, Luoling, Liu, Qian, Zhang, Lini, Wang, Zhenghao, Zhao, Ming, Lu, Qianjin, Zhu, Haizhen
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2021
• Subjects: Antiviral drugs; Autoimmune diseases; IFNAR1; innate immunity; Interferon; Kinases; Lupus; Signal transduction; SLE; Systemic lupus erythematosus; TRIM10; Tyk2 protein; type I interferon; Ubiquitin-protein ligase; type I interferon; innate immunity; SLE; TRIM10; IFNAR1

The type I interferon (IFN‐I) system is important for antiviral and anticancer immunity. Prolonged activation of IFN/JAK/STAT signaling is closely associated with autoimmune diseases. TRIM10 dysfunction may be associated closely with certain autoimmune disorders. Here, we observed that the serum TRI...