Oral Supplementation of the Vitamin D Metabolite 25(OH)D3 Against Influenza Virus Infection in Mice

• Published in: Nutrients Vol. 12; no. 7; p. 2000
• Main Authors: Hayashi, Hirotaka, Okamatsu, Masatoshi, Ogasawara, Honami, Tsugawa, Naoko, Isoda, Norikazu, Matsuno, Keita, Sakoda, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 05.07.2020; MDPI
• Subjects: Chromatography; Cytokines; Diet; Infections; Influenza; Kidneys; Lungs; Lymphocytes; Small intestine; Tumor necrosis factor-TNF; Vitamin D; United States > US; Japan

Vitamin D is a fat-soluble vitamin that is metabolized by the liver into 25-hydroxyvitamin D [25(OH)D] and then by the kidney into 1,25-dihydroxyvitamin D [1,25(OH)2D], which activates the vitamin D receptor expressed in various cells, including immune cells, for an overall immunostimulatory effect....