Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism

• Published in: EMBO reports Vol. 4; no. 1; pp. 82 - 87
• Main Authors: Mordmüller, Benjamin, Krappmann, Daniel, Esen, Meral, Wegener, Elmar, Scheidereit, Claus
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.01.2003
• Subjects: Scientific Report

The ‘classical’ NF‐κB activation pathway proceeds via IκB kinase (IKK)‐β/γ‐mediated phosphorylation, induced ubiquitination and the degradation of small IκBs. An alternative, NF‐κB‐inducing kinase and IKK‐α‐dependent pathway, which stimulates the processing of NF‐κB2/p100, has recently been suggeste...