High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells

• Published in: Journal of general virology Vol. 87; no. 12; pp. 3529 - 3538
• Main Authors: Bruce, A.G, Bakke, A.M, Bielefeldt-Ohmann, H, Ryan, J.T, Thouless, M.E, Tsai, C.C, Rose, T.M
• Format: Journal Article
• Language: English
• Published: Reading Soc General Microbiol 01.12.2006; Society for General Microbiology
• Subjects: Animals; Antigens, Viral - biosynthesis; Antigens, Viral - immunology; Biological and medical sciences; Disease Models, Animal; DNA, Viral - analysis; DNA, Viral - genetics; Fundamental and applied biological sciences. Psychology; Herpesviridae Infections - complications; Herpesviridae Infections - virology; Human herpesvirus 8; Immunohistochemistry; Kaposi's sarcoma-associated herpesvirus; Macaca; Macaca mulatta; Macaca nemestrina; Medical sciences; Microbiology; Miscellaneous; neoplasms; Nuclear Proteins - biosynthesis; Nuclear Proteins - immunology; polymerase chain reaction; Polymerase Chain Reaction - methods; Retroperitoneal Neoplasms - complications; Retroperitoneal Neoplasms - pathology; Retroperitoneal Neoplasms - virology; Rhadinovirus; Rhadinovirus - genetics; Rhadinovirus - metabolism; Rhadinovirus - physiology; Simian Acquired Immunodeficiency Syndrome - complications; Spleen - virology; Statistics as Topic; Tumor Virus Infections - complications; Tumor Virus Infections - virology; Tumors; Virology; Pseudotumor; Virus; Microbiology; Herpesviridae; Benign neoplasm; Lesion; Tumor cell; Fibromatosis; Virology

Two distinct lineages of rhadinoviruses related to Kaposi's sarcoma (KS)-associated herpesvirus (KSHV; Human herpesvirus 8), the causative agent of KS, have been identified. In macaques, the RV1 lineage is represented by retroperitoneal fibromatosis (RF) herpesvirus (RFHV), the homologue of KSH...