A food-grade self-nanoemulsifying delivery system for enhancing oral bioavailability of ellagic acid

• Published in: Journal of functional foods Vol. 34; pp. 207 - 215
• Main Authors: Wang, Shang-Ta, Chou, Chien-Te, Su, Nan-Wei
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2017; Elsevier
• Subjects: Bioavailability; Ellagic acid; Pomegranate; Self-nanoemulsifying delivery system; DE; MRM; EA-SNEDS; TPGS; AUC; Ellagic acid (PubChem CID: 5281855); Ellagic acid; CMC; ESI; GI tract; Pomegranate; Cmax; Self-nanoemulsifying delivery system; SDS; Bioavailability; SNEDS; PEG; EPA; Tmax; PEO; DHA; PTA; LCT; TEM; MCT; HLB

•A food-grade ellagic acid (EA) loaded self-nanoemulsifying system is proposed.•The system significantly enhances the dissolution of EA.•The system highly improves the oral bioavailability of EA in vivo.•EA with the system shows better bioavailability than that in pomegranate extract. Ellagic acid i...