Necroptosis and NLPR3 inflammasome activation mediated by ROS/JNK pathway participate in AlCl3-induced kidney damage

• Published in: Food and chemical toxicology Vol. 178; p. 113915
• Main Authors: Du, Jiayu, Zhang, Xuliang, Zhang, Jian, Huo, Siming, Li, Bo, Wang, Qi, Song, Miao, Shao, Bing, Li, Yanfei
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2023
• Subjects: Aluminum; inflammasomes; Kidney damage; kidneys; males; mitogen-activated protein kinase; Necroptosis; nephrotoxicity; NLRP3 inflammasome; pollutants; reactive oxygen species; ROS/JNK pathway; toxicology; ROS/JNK pathway; Kidney damage; NLRP3 inflammasome; Aluminum; Necroptosis

Aluminum (Al) is a common environmental pollutant that can induce kidney damage. However, the mechanism is not clear. In the present study, to explored the exact mechanism of AlCl3-induced nephrotoxicity, C57BL/6 N male mice and HK-2 cells were used as experimental subjects. Our results showed that...