Gene expression in the dorsal root ganglion and the cerebrospinal fluid metabolome in polyneuropathy and opioid tolerance in rats

• Published in: IBRO neuroscience reports Vol. 17; pp. 38 - 51
• Main Authors: Ahlström, Fredrik H.G., Viisanen, Hanna, Karhinen, Leena, Velagapudi, Vidya, Blomqvist, Kim J., Lilius, Tuomas O., Rauhala, Pekka V., Kalso, Eija A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2024; Elsevier
• Subjects: cerebrospinal fluid; dorsal root ganglion; Neuropathic pain; opioid tolerance; Research Paper; NP; opioid tolerance; CSF; dorsal root ganglion; cerebrospinal fluid; DRG; STZ; CNS; Neuropathic pain

First-line pharmacotherapy for peripheral neuropathic pain (NP) of diverse pathophysiology consists of antidepressants and gabapentinoids, but only a minority achieve sufficient analgesia with these drugs. Opioids are considered third-line analgesics in NP due to potential severe and unpredictable a...