Copper-mediated cascade radical cyclization of olefins with naphthalenyl iododifluoromethyl ketones

• Published in: Organic & biomolecular chemistry Vol. 17; no. 26; pp. 6426 - 6431
• Main Authors: Peng, Peng, Huang, Guo-zhi, Sun, Ying-xin, Wang, Xing, Wu, Jing-jing, Wu, Fan-hong
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 14.07.2019; Royal Society of Chemistry
• Subjects: Alkenes; Chemistry; Chemistry, Organic; Copper; Crystallography; Density functional theory; Drug discovery; Intermediates; Ketones; Physical Sciences; Powder; Regioselectivity; Science & Technology; Stereoselectivity; CATALYZED DIRECT DIFLUOROMETHYLATION; CONVENIENT SYNTHESIS; ALKENES; INTRAMOLECULAR CYCLIZATION; ACIDS; TANDEM CYCLIZATION; INHIBITORS; DIFLUOROALKYLATION; GAMMA-BUTYROLACTONES; ACCESS

Copper-mediated radical cyclization of naphthalenyl iododifluoromethyl ketones with olefins was successfully developed to generate a series of unprecedented gem -difluorodihydrophenanthrenones, especially 2,2-difluoro-3,4-dihydrophenanthren-1(2 H )-one derivatives. This strategy features the use of...