Association of micronucleus frequency with neurodegenerative diseases

• Published in: Mutagenesis Vol. 26; no. 1; pp. 85 - 92
• Main Authors: Migliore, L., Coppede, F., Fenech, M., Thomas, P.
• Format: Journal Article
• Language: English
• Published: England 01.01.2011
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - pathology; Biomarkers; Female; Fibroblasts - pathology; Humans; Lymphocytes - pathology; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mouth Mucosa - pathology; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - pathology; Parkinson Disease - genetics; Parkinson Disease - pathology; Skin - pathology

Micronuclei (MNi) can originate either from chromosome breakage or chromosome malsegregation events and are therefore ideal biomarkers to investigate genomic instability. Studies in peripheral lymphocytes of patients with neurodegenerative diseases, mainly Alzheimer's disease (AD) and Parkinson...