Disseminated Nontuberculous Mycobacterial Infection Following Cerebral Shunt Infection Caused by Mycobacterium fortuitum: A Case Report and Literature Review

A 64-year-old, previously healthy woman underwent repeated shunt removal and reinsertion for shunt dysfunction due to hydrocephalus. M. fortuitum was detected in the culture solution at the end of the removed lumboperitoneal shunt approximately one year before the diagnosis; however, the result was...

Full description

Saved in:
Bibliographic Details
Published inInternal medicine (Tokyo, 1992)
Main Authors Toyama-Kousaka, Mio, Shinoda, Masahiro, Yoshida, Takushi, Fujisaki, Marino, Sato, Takashi, Morikawa, Miwa, Takahashi, Hidenori, Shimada, Nagashige, Takei, Hiroaki, Shinkai, Masaharu
Format Journal Article
LanguageEnglish
Published Japan 05.06.2025
Subjects
cerebral shunt infection
ventriculoatrial shunt
disseminated nontuberculous mycobacterial infection
Mycobacterium fortuitum
rapidly growing mycobacteria
Online AccessGet full text

Cover

Abstract A 64-year-old, previously healthy woman underwent repeated shunt removal and reinsertion for shunt dysfunction due to hydrocephalus. M. fortuitum was detected in the culture solution at the end of the removed lumboperitoneal shunt approximately one year before the diagnosis; however, the result was considered to represent environmental contamination. The patient was hospitalized because of a high-grade fever, and M. fortuitum was detected in two blood cultures and a cerebrospinal fluid culture. We diagnosed the patient with disseminated nontuberculous mycobacterial infection due to M. fortuitum and removed the ventriculoatrial shunt. Multiple antimicrobial agents (imipenem/cilastatin, linezolid, ciprofloxacin, and trimethoprim/sulfamethoxazole) were administered for approximately two months, and the symptoms improved.
AbstractList A 64-year-old, previously healthy woman underwent repeated shunt removal and reinsertion for shunt dysfunction due to hydrocephalus. M. fortuitum was detected in the culture solution at the end of the removed lumboperitoneal shunt approximately one year before the diagnosis; however, the result was considered to represent environmental contamination. The patient was hospitalized because of a high-grade fever, and M. fortuitum was detected in two blood cultures and a cerebrospinal fluid culture. We diagnosed the patient with disseminated nontuberculous mycobacterial infection due to M. fortuitum and removed the ventriculoatrial shunt. Multiple antimicrobial agents (imipenem/cilastatin, linezolid, ciprofloxacin, and trimethoprim/sulfamethoxazole) were administered for approximately two months, and the symptoms improved.A 64-year-old, previously healthy woman underwent repeated shunt removal and reinsertion for shunt dysfunction due to hydrocephalus. M. fortuitum was detected in the culture solution at the end of the removed lumboperitoneal shunt approximately one year before the diagnosis; however, the result was considered to represent environmental contamination. The patient was hospitalized because of a high-grade fever, and M. fortuitum was detected in two blood cultures and a cerebrospinal fluid culture. We diagnosed the patient with disseminated nontuberculous mycobacterial infection due to M. fortuitum and removed the ventriculoatrial shunt. Multiple antimicrobial agents (imipenem/cilastatin, linezolid, ciprofloxacin, and trimethoprim/sulfamethoxazole) were administered for approximately two months, and the symptoms improved.
A 64-year-old, previously healthy woman underwent repeated shunt removal and reinsertion for shunt dysfunction due to hydrocephalus. M. fortuitum was detected in the culture solution at the end of the removed lumboperitoneal shunt approximately one year before the diagnosis; however, the result was considered to represent environmental contamination. The patient was hospitalized because of a high-grade fever, and M. fortuitum was detected in two blood cultures and a cerebrospinal fluid culture. We diagnosed the patient with disseminated nontuberculous mycobacterial infection due to M. fortuitum and removed the ventriculoatrial shunt. Multiple antimicrobial agents (imipenem/cilastatin, linezolid, ciprofloxacin, and trimethoprim/sulfamethoxazole) were administered for approximately two months, and the symptoms improved.
ArticleNumber 4267-24
Author Morikawa, Miwa
Shimada, Nagashige
Shinkai, Masaharu
Shinoda, Masahiro
Toyama-Kousaka, Mio
Fujisaki, Marino
Takahashi, Hidenori
Sato, Takashi
Takei, Hiroaki
Yoshida, Takushi
Author_xml – sequence: 1
  givenname: Mio
  surname: Toyama-Kousaka
  fullname: Toyama-Kousaka, Mio
– sequence: 2
  givenname: Masahiro
  surname: Shinoda
  fullname: Shinoda, Masahiro
– sequence: 3
  givenname: Takushi
  surname: Yoshida
  fullname: Yoshida, Takushi
– sequence: 4
  givenname: Marino
  surname: Fujisaki
  fullname: Fujisaki, Marino
– sequence: 5
  givenname: Takashi
  surname: Sato
  fullname: Sato, Takashi
– sequence: 6
  givenname: Miwa
  surname: Morikawa
  fullname: Morikawa, Miwa
– sequence: 7
  givenname: Hidenori
  surname: Takahashi
  fullname: Takahashi, Hidenori
– sequence: 8
  givenname: Nagashige
  surname: Shimada
  fullname: Shimada, Nagashige
– sequence: 9
  givenname: Hiroaki
  surname: Takei
  fullname: Takei, Hiroaki
– sequence: 10
  givenname: Masaharu
  surname: Shinkai
  fullname: Shinkai, Masaharu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40467497$$D View this record in MEDLINE/PubMed
BookMark eNpdkdtOGzEQhq0qqITQV6h82ZsFn_bg3kXhKAWQaLleeb2zratdO_gAysPwrjgKVIibGWnm0z-a_z9CM-ssIIQpOWG0kqfGRvBWjRP0RhsLJ4JVdcHEFzSnXMiiZrycoTmRtClYLofoKIR_hPCmluwrOhREVLWQ9Ry9nJkQYDJWRejxrbMxdeB1Gl0K-GarXad0vmXUiK_tADoaZ_GFG0f3bOwfvAIPnc_LX3-TjR-QlUohC3bbjyJpwoPzMZmYpp94maEA-B42eYaV7fHaZErF5HfTJwPPx-hgUGOAb299gR4uzn-vror13eX1arkuNK94LHrQUmnNSc_L_CTVvSjrCnrGKyJ4NkwDlaxXVdmUA6FqqDtJFVFD01HCZMkX6Mded-PdY4IQ28kEDeOoLGQjWs5oKZuSE57R729o6rL97cabSflt-25pBpo9oL0LwcPwH6Gk3aXXfk6v3aXXMsFfAZ0Ilic
Cites_doi 10.1159/000485716
10.1097/INF.0000000000001448
10.1186/1471-2180-8-184
10.1093/clind/16.4.463
10.1136/bcr-2018-226900
10.1007/s11908-016-0541-x
10.1128/CMR.00069-18
10.1016/S1473-3099(12)70316-X
10.1128/CMR.00007-10
10.5582/ddt.2020.03026
10.1016/j.idcr.2020.e00995
10.1093/jac/dkh523
10.1056/NEJMoa1111160
10.1016/0002-9343(92)90182-B
10.1164/rccm.200604-571ST
10.1016/j.rmed.2007.10.005
10.1055/s-0038-1660864
10.1093/cid/ciw861
10.1097/00007611-199907000-00009
10.1177/000992280204100610
10.1016/j.bjps.2004.06.015
10.1016/S1473-3099(21)00586-7
10.7759/cureus.7398
10.3138/jammi-2021-0003
10.14423/SMJ.0000000000000955
10.1086/520982
10.15537/smj.2020.6.25095
10.1016/j.idnow.2023.104665
10.1016/S1473-3099(08)70127-0
10.3171/2014.8.PEDS13677
10.1093/cid/cix996
10.4103/ijmy.ijmy_110_21
10.1086/655140
10.1309/HF2V-E8WV-PX4Q-CHQH
10.1227/00006123-199109000-00028
10.1016/j.idc.2018.06.006
10.1111/j.1574-6968.1998.tb13258.x
ContentType Journal Article
DBID AAYXX
CITATION
NPM
7X8
DOI 10.2169/internalmedicine.4267-24
DatabaseName CrossRef
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1349-7235
ExternalDocumentID 40467497
10_2169_internalmedicine_4267_24
Genre Journal Article
GroupedDBID ---
.55
29J
2WC
3O-
53G
5GY
AAYXX
ACPRK
ADBBV
ADRAZ
AENEX
AFRAH
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
CITATION
CS3
DIK
DU5
EBS
EJD
EMOBN
F5P
HYE
JSF
JSH
M48
OK1
OVT
P2P
PGMZT
RJT
RNS
RPM
RZJ
TKC
TR2
X7M
XSB
NPM
7X8
ID FETCH-LOGICAL-c363t-dec9acc30d350031cd4576ed236043169ce192da6585f01af7b91a0af8b102953
IEDL.DBID M48
ISSN 0918-2918
1349-7235
IngestDate Wed Jul 02 02:49:24 EDT 2025
Sun Jun 29 02:53:14 EDT 2025
Thu Jul 03 08:35:14 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords cerebral shunt infection
ventriculoatrial shunt
disseminated nontuberculous mycobacterial infection
Mycobacterium fortuitum
rapidly growing mycobacteria
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c363t-dec9acc30d350031cd4576ed236043169ce192da6585f01af7b91a0af8b102953
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_4267-24/_pdf
PMID 40467497
PQID 3215985303
PQPubID 23479
ParticipantIDs proquest_miscellaneous_3215985303
pubmed_primary_40467497
crossref_primary_10_2169_internalmedicine_4267_24
PublicationCentury 2000
PublicationDate 2025-06-05
PublicationDateYYYYMMDD 2025-06-05
PublicationDate_xml – month: 06
  year: 2025
  text: 2025-06-05
  day: 05
PublicationDecade 2020
PublicationPlace Japan
PublicationPlace_xml – name: Japan
PublicationTitle Internal medicine (Tokyo, 1992)
PublicationTitleAlternate Intern Med
PublicationYear 2025
References 22
23
24
25
26
27
28
29
30
31
10
32
11
33
12
34
13
35
14
36
15
37
16
38
17
39
18
19
1
2
3
4
5
6
7
8
9
20
21
References_xml – ident: 12
  doi: 10.1159/000485716
– ident: 10
  doi: 10.1097/INF.0000000000001448
– ident: 8
  doi: 10.1186/1471-2180-8-184
– ident: 38
  doi: 10.1093/clind/16.4.463
– ident: 27
  doi: 10.1136/bcr-2018-226900
– ident: 22
  doi: 10.1007/s11908-016-0541-x
– ident: 3
  doi: 10.1128/CMR.00069-18
– ident: 9
  doi: 10.1016/S1473-3099(12)70316-X
– ident: 39
  doi: 10.1128/CMR.00007-10
– ident: 24
  doi: 10.5582/ddt.2020.03026
– ident: 23
  doi: 10.1016/j.idcr.2020.e00995
– ident: 37
  doi: 10.1093/jac/dkh523
– ident: 33
  doi: 10.1056/NEJMoa1111160
– ident: 16
  doi: 10.1016/0002-9343(92)90182-B
– ident: 5
  doi: 10.1164/rccm.200604-571ST
– ident: 1
  doi: 10.1016/j.rmed.2007.10.005
– ident: 2
  doi: 10.1055/s-0038-1660864
– ident: 18
  doi: 10.1093/cid/ciw861
– ident: 31
  doi: 10.1097/00007611-199907000-00009
– ident: 30
  doi: 10.1177/000992280204100610
– ident: 6
  doi: 10.1016/j.bjps.2004.06.015
– ident: 36
  doi: 10.1016/S1473-3099(21)00586-7
– ident: 25
  doi: 10.7759/cureus.7398
– ident: 13
  doi: 10.3138/jammi-2021-0003
– ident: 26
  doi: 10.14423/SMJ.0000000000000955
– ident: 11
  doi: 10.1086/520982
– ident: 20
  doi: 10.15537/smj.2020.6.25095
– ident: 15
– ident: 21
  doi: 10.1016/j.idnow.2023.104665
– ident: 29
– ident: 35
  doi: 10.1016/S1473-3099(08)70127-0
– ident: 28
  doi: 10.3171/2014.8.PEDS13677
– ident: 34
  doi: 10.1093/cid/cix996
– ident: 4
  doi: 10.4103/ijmy.ijmy_110_21
– ident: 17
  doi: 10.1086/655140
– ident: 14
  doi: 10.1309/HF2V-E8WV-PX4Q-CHQH
– ident: 32
  doi: 10.1227/00006123-199109000-00028
– ident: 19
  doi: 10.1016/j.idc.2018.06.006
– ident: 7
  doi: 10.1111/j.1574-6968.1998.tb13258.x
SSID ssj0038792
Score 2.4058242
Snippet A 64-year-old, previously healthy woman underwent repeated shunt removal and reinsertion for shunt dysfunction due to hydrocephalus. M. fortuitum was detected...
SourceID proquest
pubmed
crossref
SourceType Aggregation Database
Index Database
Title Disseminated Nontuberculous Mycobacterial Infection Following Cerebral Shunt Infection Caused by Mycobacterium fortuitum: A Case Report and Literature Review
URI https://www.ncbi.nlm.nih.gov/pubmed/40467497
https://www.proquest.com/docview/3215985303
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bS8MwFA5eQHwR784bEXzNbJO0aQQRmQ6nzhcd7K2kaYqD2enWovsx_ldP2m5MUfE9OQ85Sb7v5JycD6FjQTUE_wEjNAocwt3AkMDTigAYKe6xxMSFWkP73r_u8Juu151Dk--K1QKOfgztrJ5UZ9ivv7-Oz-HAn9kyZteXJ73y7aw_yUbXAXUEoXweLQI-Catr0ObT3AILRCGVbPvyEUGZV9b3_GnpK2j9wkQLRGquopWKSuKL0vdraM6k62ipXRndQB-XNtduS12AVeL7AaBLZIY670Owj9tjDSe56NQMNlpVSVaKm7AvBm-AZ7hhhjap3McPT3mazQxpqHwEBqPxrJH8GQP9zfJelj-f4gsYNDK4ZPdYpTG-m7ZvxmU6YhN1mlePjWtSqTEQzXyWkdhoqbRmTsw8exXomEOsYmLKfNugx5faAFuMFVAaL3FclYhIuspRSRABiZEe20IL6SA1Owj7PGGCuZEyTgx3CAT3UiT28xenSRJQWUPuZLnDl7LpRgjBinVR-N1FoXVRSHkNHU38EsIJsWkPlRpY0JABq5HAShxWQ9ulw6ZWuWPVVqTY_cfsPbRMrfivfYLx9tFCNszNATCSLDoELt66PSy22ScKQeVM
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Disseminated+Nontuberculous+Mycobacterial+Infection+Following+Cerebral+Shunt+Infection+Caused+by+Mycobacterium+fortuitum%3A+A+Case+Report+and+Literature+Review&rft.jtitle=Internal+medicine+%28Tokyo%2C+1992%29&rft.au=Toyama-Kousaka%2C+Mio&rft.au=Shinoda%2C+Masahiro&rft.au=Yoshida%2C+Takushi&rft.au=Fujisaki%2C+Marino&rft.date=2025-06-05&rft.issn=1349-7235&rft.eissn=1349-7235&rft_id=info:doi/10.2169%2Finternalmedicine.4267-24&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0918-2918&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0918-2918&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0918-2918&client=summon