A molecular mechanism for the low pH stability of sialidase activity of influenza A virus N2 neuraminidases

• Published in: International Congress series Vol. 1263; pp. 781 - 786
• Main Authors: Suzuki, Takashi, Takahashi, Tadanobu, I.-P. Jwa Hidari, Kazuya, Miyamoto, Daisei, Suzuki, Yasuo
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2004
• Subjects: Chimera; Influenza virus; Low pH stability; Molecular mechanism; Neuraminidase; Sialidase; Influenza virus; Low pH stability; Molecular mechanism; Sialidase; Neuraminidase; Chimera

Four human pandemic influenza A virus strains isolated in 1957 and 1968, but not most of the epidemic strains isolated after 1968, possess sialidase activity under low pH conditions. Here we used cell-expressed neuraminidases (NAs) to determine the region of the N2 NA that is associated with low pH...