The impact of UV cross-linking on corneal stromal cell migration, differentiation and patterning
Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myo...
Saved in:
Published in | Experimental eye research Vol. 233; p. 109523 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.08.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myofibroblast differentiation on top of the stroma, we combined CXL with superficial phototherapeutic keratectomy (PTK) in a rabbit model. Twenty-six rabbits underwent a 6 mm diameter, 70 μm deep phototherapeutic keratectomy (PTK) with an excimer laser to remove the epithelium and anterior basement membrane. In 14 rabbits, standard CXL was performed in the same eye immediately after PTK. Contralateral eyes served as controls. In vivo confocal microscopy through focusing (CMTF) was used to analyze corneal epithelial and stromal thickness, as well as stromal keratocyte activation and corneal haze. CMTF scans were collected pre-operatively, and from 7 to 120 days after the procedure. A subset of rabbits was sacrificed at each time point, and corneas were fixed and labeled in situ for multiphoton fluorescence microscopy and second harmonic generation imaging. In vivo and in situ imaging demonstrated that haze after PTK was primarily derived from a layer of myofibroblasts that formed on top of the native stroma. Over time, this fibrotic layer was remodeled into more transparent stromal lamellae, and quiescent cells replaced myofibroblasts. Migrating cells within the native stroma underneath the photoablated area were elongated, co-aligned with collagen, and lacked stress fibers. In contrast, following PTK + CXL, haze was derived primarily from highly reflective necrotic “ghost cells” in the anterior stroma, and fibrosis on top of the photoablated stroma was not observed at any time point evaluated. Cells formed clusters as they migrated into the cross-linked stromal tissue and expressed stress fibers; some cells at the edge of the CXL area also expressed α-SM actin, suggesting myofibroblast transformation. Stromal thickness increased significantly between 21 and 90 days after PTK + CXL (P < 0.001) and was over 35 μm higher than baseline at Day 90 (P < 0.05). Overall, these data suggest that cross-linking inhibits interlamellar cell movement, and that these changes lead to a disruption of normal keratocyte patterning and increased activation during stromal repopulation. Interestingly, CXL also prevents PTK-induced fibrosis on top of the stroma, and results in long term increases in stromal thickness in the rabbit model.
•Cross-linking (CXL) disrupts keratoctye patterning during instrastromal migration.•Cell clustering and stress fiber formation is observed after CXL.•CXL blocks fibrosis after phototherapeutic keratectomy (PTK).•PTK + CXL induces a progressive increase in stromal thickness in the rabbit model. |
---|---|
AbstractList | Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myofibroblast differentiation on top of the stroma, we combined CXL with superficial phototherapeutic keratectomy (PTK) in a rabbit model. Twenty-six rabbits underwent a 6 mm diameter, 70 μm deep phototherapeutic keratectomy (PTK) with an excimer laser to remove the epithelium and anterior basement membrane. In 14 rabbits, standard CXL was performed in the same eye immediately after PTK. Contralateral eyes served as controls. In vivo confocal microscopy through focusing (CMTF) was used to analyze corneal epithelial and stromal thickness, as well as stromal keratocyte activation and corneal haze. CMTF scans were collected pre-operatively, and from 7 to 120 days after the procedure. A subset of rabbits was sacrificed at each time point, and corneas were fixed and labeled in situ for multiphoton fluorescence microscopy and second harmonic generation imaging. In vivo and in situ imaging demonstrated that haze after PTK was primarily derived from a layer of myofibroblasts that formed on top of the native stroma. Over time, this fibrotic layer was remodeled into more transparent stromal lamellae, and quiescent cells replaced myofibroblasts. Migrating cells within the native stroma underneath the photoablated area were elongated, co-aligned with collagen, and lacked stress fibers. In contrast, following PTK + CXL, haze was derived primarily from highly reflective necrotic "ghost cells" in the anterior stroma, and fibrosis on top of the photoablated stroma was not observed at any time point evaluated. Cells formed clusters as they migrated into the cross-linked stromal tissue and expressed stress fibers; some cells at the edge of the CXL area also expressed α-SM actin, suggesting myofibroblast transformation. Stromal thickness increased significantly between 21 and 90 days after PTK + CXL (P < 0.001) and was over 35 μm higher than baseline at Day 90 (P < 0.05). Overall, these data suggest that cross-linking inhibits interlamellar cell movement, and that these changes lead to a disruption of normal keratocyte patterning and increased activation during stromal repopulation. Interestingly, CXL also prevents PTK-induced fibrosis on top of the stroma, and results in long term increases in stromal thickness in the rabbit model. Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myofibroblast differentiation on top of the stroma, we combined CXL with superficial phototherapeutic keratectomy (PTK) in a rabbit model. Twenty-six rabbits underwent a 6 mm diameter, 70 μm deep phototherapeutic keratectomy (PTK) with an excimer laser to remove the epithelium and anterior basement membrane. In 14 rabbits, standard CXL was performed in the same eye immediately after PTK. Contralateral eyes served as controls. In vivo confocal microscopy through focusing (CMTF) was used to analyze corneal epithelial and stromal thickness, as well as stromal keratocyte activation and corneal haze. CMTF scans were collected pre-operatively, and from 7 to 120 days after the procedure. A subset of rabbits was sacrificed at each time point, and corneas were fixed and labeled in situ for multiphoton fluorescence microscopy and second harmonic generation imaging. In vivo and in situ imaging demonstrated that haze after PTK was primarily derived from a layer of myofibroblasts that formed on top of the native stroma. Over time, this fibrotic layer was remodeled into more transparent stromal lamellae, and quiescent cells replaced myofibroblasts. Migrating cells within the native stroma underneath the photoablated area were elongated, co-aligned with collagen, and lacked stress fibers. In contrast, following PTK+CXL, haze was derived primarily from highly reflective necrotic “ghost cells” in the anterior stroma, and fibrosis on top of the photoablated stroma was not observed at any time point evaluated. Cells formed clusters as they migrated into the cross-linked stromal tissue and expressed stress fibers; some cells at the edge of the CXL area also expressed α-SM actin, suggesting myofibroblast transformation. Stromal thickness increased significantly between 21 and 90 days after PTK+CXL (P < 0.001) and was over 35 μm higher than baseline at Day 90 (P < 0.05). Overall, these data suggest that cross-linking inhibits interlamellar cell movement, and that these changes lead to a disruption of normal keratocyte patterning and increased activation during stromal repopulation. Interestingly, CXL also prevents PTK-induced fibrosis on top of the stroma, and results in long term increases in stromal thickness in the rabbit model. Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myofibroblast differentiation on top of the stroma, we combined CXL with superficial phototherapeutic keratectomy (PTK) in a rabbit model. Twenty-six rabbits underwent a 6 mm diameter, 70 μm deep phototherapeutic keratectomy (PTK) with an excimer laser to remove the epithelium and anterior basement membrane. In 14 rabbits, standard CXL was performed in the same eye immediately after PTK. Contralateral eyes served as controls. In vivo confocal microscopy through focusing (CMTF) was used to analyze corneal epithelial and stromal thickness, as well as stromal keratocyte activation and corneal haze. CMTF scans were collected pre-operatively, and from 7 to 120 days after the procedure. A subset of rabbits was sacrificed at each time point, and corneas were fixed and labeled in situ for multiphoton fluorescence microscopy and second harmonic generation imaging. In vivo and in situ imaging demonstrated that haze after PTK was primarily derived from a layer of myofibroblasts that formed on top of the native stroma. Over time, this fibrotic layer was remodeled into more transparent stromal lamellae, and quiescent cells replaced myofibroblasts. Migrating cells within the native stroma underneath the photoablated area were elongated, co-aligned with collagen, and lacked stress fibers. In contrast, following PTK + CXL, haze was derived primarily from highly reflective necrotic "ghost cells" in the anterior stroma, and fibrosis on top of the photoablated stroma was not observed at any time point evaluated. Cells formed clusters as they migrated into the cross-linked stromal tissue and expressed stress fibers; some cells at the edge of the CXL area also expressed α-SM actin, suggesting myofibroblast transformation. Stromal thickness increased significantly between 21 and 90 days after PTK + CXL (P < 0.001) and was over 35 μm higher than baseline at Day 90 (P < 0.05). Overall, these data suggest that cross-linking inhibits interlamellar cell movement, and that these changes lead to a disruption of normal keratocyte patterning and increased activation during stromal repopulation. Interestingly, CXL also prevents PTK-induced fibrosis on top of the stroma, and results in long term increases in stromal thickness in the rabbit model.Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myofibroblast differentiation on top of the stroma, we combined CXL with superficial phototherapeutic keratectomy (PTK) in a rabbit model. Twenty-six rabbits underwent a 6 mm diameter, 70 μm deep phototherapeutic keratectomy (PTK) with an excimer laser to remove the epithelium and anterior basement membrane. In 14 rabbits, standard CXL was performed in the same eye immediately after PTK. Contralateral eyes served as controls. In vivo confocal microscopy through focusing (CMTF) was used to analyze corneal epithelial and stromal thickness, as well as stromal keratocyte activation and corneal haze. CMTF scans were collected pre-operatively, and from 7 to 120 days after the procedure. A subset of rabbits was sacrificed at each time point, and corneas were fixed and labeled in situ for multiphoton fluorescence microscopy and second harmonic generation imaging. In vivo and in situ imaging demonstrated that haze after PTK was primarily derived from a layer of myofibroblasts that formed on top of the native stroma. Over time, this fibrotic layer was remodeled into more transparent stromal lamellae, and quiescent cells replaced myofibroblasts. Migrating cells within the native stroma underneath the photoablated area were elongated, co-aligned with collagen, and lacked stress fibers. In contrast, following PTK + CXL, haze was derived primarily from highly reflective necrotic "ghost cells" in the anterior stroma, and fibrosis on top of the photoablated stroma was not observed at any time point evaluated. Cells formed clusters as they migrated into the cross-linked stromal tissue and expressed stress fibers; some cells at the edge of the CXL area also expressed α-SM actin, suggesting myofibroblast transformation. Stromal thickness increased significantly between 21 and 90 days after PTK + CXL (P < 0.001) and was over 35 μm higher than baseline at Day 90 (P < 0.05). Overall, these data suggest that cross-linking inhibits interlamellar cell movement, and that these changes lead to a disruption of normal keratocyte patterning and increased activation during stromal repopulation. Interestingly, CXL also prevents PTK-induced fibrosis on top of the stroma, and results in long term increases in stromal thickness in the rabbit model. Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM) microstructure. In order to investigate how CXL impacts both keratocyte differentiation and patterning within the stroma, and fibroblast migration and myofibroblast differentiation on top of the stroma, we combined CXL with superficial phototherapeutic keratectomy (PTK) in a rabbit model. Twenty-six rabbits underwent a 6 mm diameter, 70 μm deep phototherapeutic keratectomy (PTK) with an excimer laser to remove the epithelium and anterior basement membrane. In 14 rabbits, standard CXL was performed in the same eye immediately after PTK. Contralateral eyes served as controls. In vivo confocal microscopy through focusing (CMTF) was used to analyze corneal epithelial and stromal thickness, as well as stromal keratocyte activation and corneal haze. CMTF scans were collected pre-operatively, and from 7 to 120 days after the procedure. A subset of rabbits was sacrificed at each time point, and corneas were fixed and labeled in situ for multiphoton fluorescence microscopy and second harmonic generation imaging. In vivo and in situ imaging demonstrated that haze after PTK was primarily derived from a layer of myofibroblasts that formed on top of the native stroma. Over time, this fibrotic layer was remodeled into more transparent stromal lamellae, and quiescent cells replaced myofibroblasts. Migrating cells within the native stroma underneath the photoablated area were elongated, co-aligned with collagen, and lacked stress fibers. In contrast, following PTK + CXL, haze was derived primarily from highly reflective necrotic “ghost cells” in the anterior stroma, and fibrosis on top of the photoablated stroma was not observed at any time point evaluated. Cells formed clusters as they migrated into the cross-linked stromal tissue and expressed stress fibers; some cells at the edge of the CXL area also expressed α-SM actin, suggesting myofibroblast transformation. Stromal thickness increased significantly between 21 and 90 days after PTK + CXL (P < 0.001) and was over 35 μm higher than baseline at Day 90 (P < 0.05). Overall, these data suggest that cross-linking inhibits interlamellar cell movement, and that these changes lead to a disruption of normal keratocyte patterning and increased activation during stromal repopulation. Interestingly, CXL also prevents PTK-induced fibrosis on top of the stroma, and results in long term increases in stromal thickness in the rabbit model. •Cross-linking (CXL) disrupts keratoctye patterning during instrastromal migration.•Cell clustering and stress fiber formation is observed after CXL.•CXL blocks fibrosis after phototherapeutic keratectomy (PTK).•PTK + CXL induces a progressive increase in stromal thickness in the rabbit model. |
ArticleNumber | 109523 |
Author | Miron-Mendoza, Miguel Sunkara, Yukta Ikebe, Hikaru R. Hassaniardekani, Hajar Sripathi, Nishith R. Petroll, W. Matthew |
AuthorAffiliation | 2 Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX 1 Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX |
AuthorAffiliation_xml | – name: 2 Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX – name: 1 Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX |
Author_xml | – sequence: 1 givenname: W. Matthew orcidid: 0000-0003-0795-4539 surname: Petroll fullname: Petroll, W. Matthew email: matthew.petroll@utsouthwestern.edu organization: Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USA – sequence: 2 givenname: Miguel surname: Miron-Mendoza fullname: Miron-Mendoza, Miguel organization: Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USA – sequence: 3 givenname: Yukta surname: Sunkara fullname: Sunkara, Yukta organization: Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USA – sequence: 4 givenname: Hikaru R. surname: Ikebe fullname: Ikebe, Hikaru R. organization: Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USA – sequence: 5 givenname: Nishith R. surname: Sripathi fullname: Sripathi, Nishith R. organization: Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USA – sequence: 6 givenname: Hajar surname: Hassaniardekani fullname: Hassaniardekani, Hajar organization: Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37271309$$D View this record in MEDLINE/PubMed |
BookMark | eNp9UctuFDEQtFAQ2QR-gAPykQOz-DnjkZAQinhJkXJJuBqv3d54mbEX2xslf483GyK45NStclW5u-sEHcUUAaHXlCwpof37zRJuIS8ZYbwBo2T8GVq0pu8IIcMRWhBCRScUl8fopJRNQ7kYxAt0zAc2UE7GBfp5eQ04zFtjK04eX_3ANqdSuinEXyGucYrYphzBTLjUnOZWLUwTnsM6mxpSfIdd8B4yxBruAWyiw1tTK-TYHF6i595MBV491FN09eXz5dm37vzi6_ezT-ed5T2vnXVeECe5IH50isqeDwBCUaPYyAYlhbJGCEl6M4Jw_eCpIGa14p5ZkKAEP0UfD77b3WoGZ9s82Ux6m8Ns8p1OJuj_X2K41ut0oylRTKpxbA5vHxxy-r2DUvUcyn5ZEyHtimaKsYH0RNJGZQfq_bEy-Md_KNH7bPRG77PR-2z0IZsmevPvhI-Sv2E0wocDAdqdbkKTFxsgWnAhg63apfCU_x98raNc |
Cites_doi | 10.1016/j.preteyeres.2021.101016 10.1016/S0002-9394(02)02220-1 10.1016/j.bpj.2020.08.040 10.3390/jfb3010183 10.1111/j.1755-3768.2008.01190.x 10.1111/j.1442-9071.2011.02634.x 10.1016/j.actbio.2017.05.051 10.1038/srep42896 10.1016/j.jtos.2015.04.007 10.3390/ijms24087437 10.1016/j.jtos.2015.05.002 10.3928/1081597X-20101201-02 10.1007/s00018-022-04184-7 10.1016/S1350-9462(98)00021-4 10.1167/iovs.11-9092 10.1167/iovs.09-4074 10.1242/jcs.112.5.613 10.1016/j.ajoc.2019.02.008 10.1016/j.exer.2020.108089 10.1167/iovs.15-16584 10.1038/s41433-018-0075-6 10.1242/jcs.00383 10.1097/ICL.0b013e3181ee8992 10.1016/j.yexcr.2006.08.009 10.1016/j.exer.2022.109112 10.1016/j.jcrs.2016.06.040 10.1016/j.bpj.2009.04.024 10.1097/01.icu.0000233954.86723.25 10.1097/ICO.0b013e31824d701b 10.1038/s41598-018-30372-2 10.1097/ICO.0b013e3181bdf1cc 10.1016/S0039-6257(97)00119-7 10.1167/iovs.11-8155 10.1167/tvst.11.7.9 10.1016/j.exer.2018.08.009 10.1016/j.clae.2021.101559 10.1167/iovs.08-1983 10.1080/08820538.2022.2152716 10.1167/iovs.12-11575 10.1002/jbm.a.30089 10.1167/iovs.11-7184 10.1167/iovs.02-1188 10.1167/iovs.11-7982 10.3928/1081597X-20190625-02 10.1097/01.ico.0000151544.23360.17 10.1097/ICO.0000000000002781 10.1167/iovs.61.2.28 10.1167/iovs.02-0860 10.1167/iovs.12-11007 10.1097/00003226-199811000-00011 10.1016/j.ophtha.2013.09.014 10.1167/iovs.11-8609 10.1038/s41598-018-30964-y 10.1016/j.ajo.2016.12.015 10.3928/1081597X-20090813-12 10.1016/j.jcrs.2019.06.027 10.1016/j.exer.2020.108228 10.1016/j.exer.2007.06.009 10.3389/fcell.2022.886759 10.1097/ICO.0000000000001047 10.3390/jfb9040054 10.1007/s10544-019-0436-3 10.1097/ICL.0000000000000892 10.1073/pnas.1313561110 10.1364/OE.18.024983 10.1038/srep25534 10.1016/j.exer.2017.05.003 10.1167/iovs.09-4200 10.3390/nu14040913 10.1016/S0161-6420(00)00142-1 10.1016/j.jtos.2020.03.006 10.1016/j.survophthal.2015.02.004 10.1016/j.jcrs.2012.11.036 10.1016/j.exer.2016.10.009 10.1016/j.jcrs.2013.01.026 10.1016/S0161-6420(97)30307-8 10.1097/00003226-200401000-00008 10.3390/jfb6020422 10.1016/j.ajo.2008.05.042 10.1016/S0014-4835(02)00251-8 10.1167/tvst.8.6.35 10.1016/j.bpj.2015.06.058 10.1097/ICO.0b013e31825ec44e 10.1371/journal.pone.0200704 10.2147/OPTH.S2800 10.1167/iovs.15-17978 |
ContentType | Journal Article |
Copyright | 2023 Elsevier Ltd Copyright © 2023 Elsevier Ltd. All rights reserved. |
Copyright_xml | – notice: 2023 Elsevier Ltd – notice: Copyright © 2023 Elsevier Ltd. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
DOI | 10.1016/j.exer.2023.109523 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1096-0007 |
EndPage | 109523 |
ExternalDocumentID | 10_1016_j_exer_2023_109523 37271309 S0014483523001446 |
Genre | Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: NEI NIH HHS grantid: T35 EY026510 – fundername: NEI NIH HHS grantid: R01 EY013322 – fundername: NEI NIH HHS grantid: P30 EY030413 |
GroupedDBID | --- --K --M .55 .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29G 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AAXLA AAXUO ABBQC ABCQJ ABFNM ABJNI ABLJU ABLVK ABMAC ABMZM ABXDB ABYKQ ACDAQ ACGFS ACNCT ACRLP ADBBV ADEZE ADFGL ADMUD AEBSH AEKER AENEX AFFNX AFKWA AFTJW AFXIZ AGEKW AGHFR AGUBO AGWIK AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 CAG CJTIS COF CS3 DM4 DU5 EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HMK HMO HMQ HVGLF HZ~ IHE J1W KOM L7B LCYCR LG5 LUGTX LZ2 M29 M2U M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SES SEW SNS SPCBC SSH SSI SSN SSZ T5K TEORI WUQ X7M XPP ZA5 ZGI ZMT ZU3 ~G- AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c363t-cdf40d5340f9d815637ee481a829278548ca44506a9e4d67f140abb3f2ce5e843 |
IEDL.DBID | AIKHN |
ISSN | 0014-4835 1096-0007 |
IngestDate | Tue Sep 17 21:28:54 EDT 2024 Wed Aug 07 11:44:54 EDT 2024 Thu Sep 26 19:55:30 EDT 2024 Wed Oct 02 05:23:38 EDT 2024 Fri Feb 23 02:35:30 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Corneal wound healing Confocal microscopy Extracellular matrix Corneal cross-linking Second harmonic generation imaging |
Language | English |
License | Copyright © 2023 Elsevier Ltd. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c363t-cdf40d5340f9d815637ee481a829278548ca44506a9e4d67f140abb3f2ce5e843 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-0795-4539 |
PMID | 37271309 |
PQID | 2822706051 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_10825899 proquest_miscellaneous_2822706051 crossref_primary_10_1016_j_exer_2023_109523 pubmed_primary_37271309 elsevier_sciencedirect_doi_10_1016_j_exer_2023_109523 |
PublicationCentury | 2000 |
PublicationDate | 2023-08-01 |
PublicationDateYYYYMMDD | 2023-08-01 |
PublicationDate_xml | – month: 08 year: 2023 text: 2023-08-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Experimental eye research |
PublicationTitleAlternate | Exp Eye Res |
PublicationYear | 2023 |
Publisher | Elsevier Ltd |
Publisher_xml | – name: Elsevier Ltd |
References | Mazzotta, Hafezi, Kymionis, Caragiuli, Jacob, Traversi, Barabino, Randleman (bib46) 2015; 13 Tan, Chang, Lo, Hsueh, Chen, Ghazaryan, Hu, Young, Chen, Dong (bib79) 2013; 39 Helena, Baerveldt, Kim, Wilson (bib20) 1998; 39 Kim, Lakshman, Petroll (bib35) 2006; 312 Kivanany, Grose, Tippani, Su, Petroll (bib37) 2018; 8 Moller-Pedersen, Cavanagh, Petroll, Jester (bib52) 1998; 17 Wilson, Chaurasia, Medeiros (bib87) 2007; 85 Maruri, Miron-Mendoza, Kivanany, Hack, Schmidtke, Petroll, Varner (bib45) 2020; 119 Teixeira, Abrams, Bertics, Murphy, Nealey (bib80) 2003; 116 Blalock, Duncan, Varela, Goldstein, Tuli, Grotensdorst, Schultz (bib6) 2003; 44 McKay, Hjortdal, Sejersen, Asara, Wu, Karamichos (bib48) 2016; 6 de Oliveira, Wilson (bib11) 2020; 61 Stewart, Lee, Wong, Schultz, Lamy (bib77) 2011; 52 Jester, Brown, Pappa, Vasiliou (bib26) 2012; 53 Petroll, Kivanany, Hagenasr, Graham (bib61) 2015; 56 Hovakimyan, Guthoff, Reichard, Wree, Nolte, Stachs (bib21) 2011; 39 Farid, Morishige, Lam, Wahlert, Steinert, Jester (bib14) 2008; 49 Rabinowitz (bib67) 1998; 42 Raghunathan, Thomasy, Strom, Yanez-Soto, Garland, Sermeno, Reilly, Murphy (bib69) 2017; 58 Lakshman, Petroll (bib39) 2012; 53 Wilson (bib83) 2019; 35 Lasagni Vitar, Bonelli, Rama, Ferrari (bib41) 2022; 14 Netto, Mohan, Ambrosio, Hutcheon, Zieske, Wilson (bib57) 2005; 24 Beckman, Gupta, Farid, Berdahl, Yeu, Ayres, Chan, Gomes, Holland, Kim, Starr, Mah, Committee (bib2) 2019; 45 Santodomingo-Rubido, Carracedo, Suzaki, Villa-Collar, Vincent, Wolffsohn (bib73) 2022; 45 Marino, Santhiago, Santhanam, Lassance, Thangavadivel, Medeiros, Bose, Tam, Wilson (bib43) 2017; 161 Sharif, Fowler, Karamichos (bib74) 2018; 13 Bradford, Mikula, Kim, Xie, Juhasz, Brown, Jester (bib7) 2019; 8 Wollensak, Spoerl, Wilsch, Seiler (bib92) 2004; 23 Godefrooij, de Wit, Uiterwaal, Imhof, Wisse (bib18) 2017; 175 Jester, Petroll, Barry, Cavanagh (bib29) 1995; 186 Petroll, Varner, Schmidtke (bib64) 2020; 200 Jester, Moller-Pedersen, Huang, Sax, Kays, Cavanagh, Petroll, Piatigorsky (bib28) 1999; 112 Sampaio, Hilgert, Shiju, Santhiago, Wilson (bib72) 2022; 11 Garana, Petroll, Chen, Herman, Barry, Andrews, Cavanagh, Jester (bib16) 1992; 33 Parker, van Dijk, Melles (bib58) 2015; 60 Young, Knupp, Pinali, Png, Ralphs, Bushby, Starborg, Kadler, Quantock (bib93) 2014; 111 Jester, Petroll, Cavanagh (bib30) 1999; 18 Myrna, Mendonsa, Russell, Pot, Liliensiek, Jester, Nealey, Brown, Murphy (bib56) 2012; 53 Moller-Pedersen, Li, Petroll, Cavanagh, Jester (bib54) 1998; 39 Kivanany, Grose, Yonet-Tanyeri, Manohar, Sunkara, Lam, Schmidtke, Varner, Petroll (bib38) 2018; 9 Bradford, Mikula, Juhasz, Brown, Jester (bib9) 2018; 177 Hovakimyan, Stachs, Celine, Guthoff (bib22) 2016; 35 Ferrari, Rama (bib15) 2020; 18 Jester, Winkler, Jester, Nien, Chai, Brown (bib31) 2010; 36 Wilson (bib84) 2020; 197 Akoto, Cai, Nicholas, McCord, Estes, Xu, Karamichos, Liu (bib1) 2023; 24 Moller-Pedersen, Cavanagh, Petroll, Jester (bib53) 2000; 107 Jeon, Hindman, Bubel, McDaniel, DeMagistris, Callan, Huxlin (bib24) 2018; 8 Jordan, Patel, Abeysekera, McGhee (bib32) 2014; 121 Sivaguru, Durgam, Ambekar, Luedtke, Fried, Stewart, Toussaint (bib76) 2010; 18 Lyon, McKay, Sarkar-Nag, Priyadarsini, Karamichos (bib42) 2015; 6 Esquenazi, He, Li, Bazan (bib13) 2010; 29 Peponis, Kontomichos, Chatziralli, Kontadakis, Parikakis (bib60) 2019; 14 Petroll, Lakshman, Ma (bib62) 2012; 3 McKay, Hjortdal, Sejersen, Karamichos (bib49) 2017; 7 Raiskup, Hoyer, Spoerl (bib70) 2009; 25 Mazzotta, Traversi, Baiocchi, Caporossi, Bovone, Sparano, Balestrazzi, Caporossi (bib47) 2008; 146 Raghunathan, Morgan, Dreier, Reilly, Thomasy, Wood, Ly, Tuyen, Hughbanks, Murphy, Russell (bib68) 2013; 54 Stramer, Zieske, Jung, Austin, Fini (bib78) 2003; 44 Winkler, Shoa, Tran, Xie, Thomasy, Raghunathan, Murphy, Brown, Jester (bib88) 2015; 56 Sharif, Sejersen, Frank, Hjortdal, Karamichos (bib75) 2018; 32 He, Liu, Li, Ma, Huo, Ji (bib19) 2015; 109 Lam, Kivanany, Grose, Yonet-Tanyeri, Alsmadi, Varner, Petroll, Schmidtke (bib40) 2019; 21 Parsa, Rodriguez, Robertson, Bowman, Petroll (bib59) 2022; 48 Jester, Huang, Barry-Lane, Kao, Petroll, Cavanagh (bib27) 1999; 40 Bueno, Gualda, Giakoumaki, Perez-Merino, Marcos, Artal (bib10) 2011; 52 Wollensak, Iomdina (bib90) 2009; 87 Karamichos, Escandon, Vasini, Nicholas, Van, Dang, Cunningham, Riaz (bib33) 2022; 88 Kivanany, Grose, Petroll (bib36) 2016; 153 Wollensak, Spoerl, Seiler (bib91) 2003; 135 Messmer, Meyer, Herwig, Loeffler, Schirra, Seitz, Thiel, Reinhard, Kampik, Auw-Haedrich (bib50) 2013; 32 Moller-Pedersen, Vogel, Li, Petroll, Cavanagh, Jester (bib55) 1997; 104 Petroll, Weaver, Vaidya, McCulley, Cavanagh (bib65) 2013; 32 Jester, Barry, Lind, Petroll, Garana, Cavanagh (bib25) 1994; 35 Salomao, Chaurasia, Sinha-Roy, Ambrosio, Esposito, Sepulveda, Agrawal, Wilson (bib71) 2011; 27 Wollensak (bib89) 2006; 17 Belin, Jang, Borgstrom (bib3) 2022; 41 Tomkins, Garzozi (bib82) 2008; 2 Iyer, Maruri, Peak, Schmidtke, Petroll, Varner (bib23) 2022; 220 Bevara, Vaddavalli (bib5) 2023; 38 Wilson (bib85) 2022; 79 Teixeira, Nealey, Murphy (bib81) 2004; 71A Wilson (bib86) 2022 Bradford, Brown, Juhasz, Mikula, Jester (bib8) 2016; 42 Maruri, Iyer, Schmidtke, Petroll, Varner (bib44) 2022; 10 Beshtawi, O'Donnell, Radhakrishnan (bib4) 2013; 39 Pot, Liliensiek, Myrna, Bentley, Jester, Nealey, Murphy (bib66) 2010; 51 Dreier, Thomasy, Mendonsa, Raghunathan, Russell, Murphy (bib12) 2013; 54 Kim, Lakshman, Karamichos, Petroll (bib34) 2010; 51 Mohan, Hutcheon, Choi, Hong, Lee, Mohan, Ambrósio, Zieske, Wilson (bib51) 2003; 76 Ghibaudo, Trichet, Le Digabel, Richert, Hersen, Ladoux (bib17) 2009; 97 Petroll, Robertson (bib63) 2015; 13 Bevara (10.1016/j.exer.2023.109523_bib5) 2023; 38 Wilson (10.1016/j.exer.2023.109523_bib87) 2007; 85 Hovakimyan (10.1016/j.exer.2023.109523_bib21) 2011; 39 Mohan (10.1016/j.exer.2023.109523_bib51) 2003; 76 Petroll (10.1016/j.exer.2023.109523_bib65) 2013; 32 Wollensak (10.1016/j.exer.2023.109523_bib89) 2006; 17 Beckman (10.1016/j.exer.2023.109523_bib2) 2019; 45 Moller-Pedersen (10.1016/j.exer.2023.109523_bib53) 2000; 107 Sharif (10.1016/j.exer.2023.109523_bib75) 2018; 32 Lam (10.1016/j.exer.2023.109523_bib40) 2019; 21 Rabinowitz (10.1016/j.exer.2023.109523_bib67) 1998; 42 Petroll (10.1016/j.exer.2023.109523_bib64) 2020; 200 Sampaio (10.1016/j.exer.2023.109523_bib72) 2022; 11 Jester (10.1016/j.exer.2023.109523_bib30) 1999; 18 Jordan (10.1016/j.exer.2023.109523_bib32) 2014; 121 Moller-Pedersen (10.1016/j.exer.2023.109523_bib55) 1997; 104 Helena (10.1016/j.exer.2023.109523_bib20) 1998; 39 Wollensak (10.1016/j.exer.2023.109523_bib91) 2003; 135 He (10.1016/j.exer.2023.109523_bib19) 2015; 109 Messmer (10.1016/j.exer.2023.109523_bib50) 2013; 32 Karamichos (10.1016/j.exer.2023.109523_bib33) 2022; 88 Moller-Pedersen (10.1016/j.exer.2023.109523_bib52) 1998; 17 Peponis (10.1016/j.exer.2023.109523_bib60) 2019; 14 Teixeira (10.1016/j.exer.2023.109523_bib80) 2003; 116 Salomao (10.1016/j.exer.2023.109523_bib71) 2011; 27 Kivanany (10.1016/j.exer.2023.109523_bib36) 2016; 153 McKay (10.1016/j.exer.2023.109523_bib48) 2016; 6 Esquenazi (10.1016/j.exer.2023.109523_bib13) 2010; 29 Farid (10.1016/j.exer.2023.109523_bib14) 2008; 49 Kivanany (10.1016/j.exer.2023.109523_bib38) 2018; 9 Jester (10.1016/j.exer.2023.109523_bib28) 1999; 112 Winkler (10.1016/j.exer.2023.109523_bib88) 2015; 56 Teixeira (10.1016/j.exer.2023.109523_bib81) 2004; 71A Maruri (10.1016/j.exer.2023.109523_bib45) 2020; 119 Wollensak (10.1016/j.exer.2023.109523_bib90) 2009; 87 Wilson (10.1016/j.exer.2023.109523_bib84) 2020; 197 Bradford (10.1016/j.exer.2023.109523_bib7) 2019; 8 Myrna (10.1016/j.exer.2023.109523_bib56) 2012; 53 Mazzotta (10.1016/j.exer.2023.109523_bib46) 2015; 13 Kivanany (10.1016/j.exer.2023.109523_bib37) 2018; 8 Raiskup (10.1016/j.exer.2023.109523_bib70) 2009; 25 de Oliveira (10.1016/j.exer.2023.109523_bib11) 2020; 61 Kim (10.1016/j.exer.2023.109523_bib35) 2006; 312 Santodomingo-Rubido (10.1016/j.exer.2023.109523_bib73) 2022; 45 Bueno (10.1016/j.exer.2023.109523_bib10) 2011; 52 Petroll (10.1016/j.exer.2023.109523_bib61) 2015; 56 Petroll (10.1016/j.exer.2023.109523_bib62) 2012; 3 Mazzotta (10.1016/j.exer.2023.109523_bib47) 2008; 146 Wilson (10.1016/j.exer.2023.109523_bib85) 2022; 79 Jester (10.1016/j.exer.2023.109523_bib29) 1995; 186 Marino (10.1016/j.exer.2023.109523_bib43) 2017; 161 Maruri (10.1016/j.exer.2023.109523_bib44) 2022; 10 Belin (10.1016/j.exer.2023.109523_bib3) 2022; 41 Bradford (10.1016/j.exer.2023.109523_bib8) 2016; 42 Stramer (10.1016/j.exer.2023.109523_bib78) 2003; 44 Iyer (10.1016/j.exer.2023.109523_bib23) 2022; 220 Tomkins (10.1016/j.exer.2023.109523_bib82) 2008; 2 Wilson (10.1016/j.exer.2023.109523_bib83) 2019; 35 Ferrari (10.1016/j.exer.2023.109523_bib15) 2020; 18 Lyon (10.1016/j.exer.2023.109523_bib42) 2015; 6 Stewart (10.1016/j.exer.2023.109523_bib77) 2011; 52 Wollensak (10.1016/j.exer.2023.109523_bib92) 2004; 23 Sivaguru (10.1016/j.exer.2023.109523_bib76) 2010; 18 Dreier (10.1016/j.exer.2023.109523_bib12) 2013; 54 Lasagni Vitar (10.1016/j.exer.2023.109523_bib41) 2022; 14 Garana (10.1016/j.exer.2023.109523_bib16) 1992; 33 Jester (10.1016/j.exer.2023.109523_bib27) 1999; 40 Sharif (10.1016/j.exer.2023.109523_bib74) 2018; 13 Tan (10.1016/j.exer.2023.109523_bib79) 2013; 39 Lakshman (10.1016/j.exer.2023.109523_bib39) 2012; 53 Moller-Pedersen (10.1016/j.exer.2023.109523_bib54) 1998; 39 Jeon (10.1016/j.exer.2023.109523_bib24) 2018; 8 Parker (10.1016/j.exer.2023.109523_bib58) 2015; 60 Raghunathan (10.1016/j.exer.2023.109523_bib68) 2013; 54 Akoto (10.1016/j.exer.2023.109523_bib1) 2023; 24 Jester (10.1016/j.exer.2023.109523_bib31) 2010; 36 Petroll (10.1016/j.exer.2023.109523_bib63) 2015; 13 Jester (10.1016/j.exer.2023.109523_bib26) 2012; 53 Jester (10.1016/j.exer.2023.109523_bib25) 1994; 35 McKay (10.1016/j.exer.2023.109523_bib49) 2017; 7 Bradford (10.1016/j.exer.2023.109523_bib9) 2018; 177 Kim (10.1016/j.exer.2023.109523_bib34) 2010; 51 Beshtawi (10.1016/j.exer.2023.109523_bib4) 2013; 39 Raghunathan (10.1016/j.exer.2023.109523_bib69) 2017; 58 Parsa (10.1016/j.exer.2023.109523_bib59) 2022; 48 Ghibaudo (10.1016/j.exer.2023.109523_bib17) 2009; 97 Pot (10.1016/j.exer.2023.109523_bib66) 2010; 51 Wilson (10.1016/j.exer.2023.109523_bib86) 2022 Young (10.1016/j.exer.2023.109523_bib93) 2014; 111 Blalock (10.1016/j.exer.2023.109523_bib6) 2003; 44 Godefrooij (10.1016/j.exer.2023.109523_bib18) 2017; 175 Hovakimyan (10.1016/j.exer.2023.109523_bib22) 2016; 35 Netto (10.1016/j.exer.2023.109523_bib57) 2005; 24 |
References_xml | – year: 2022 ident: bib86 article-title: Fibrosis Is a Basement Membrane-Related Disease in the Cornea: Injury and Defective Regeneration of Basement Membranes May Underlie Fibrosis in Other Organs contributor: fullname: Wilson – volume: 25 start-page: S824 year: 2009 end-page: S828 ident: bib70 article-title: Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus publication-title: J. Refract. Surg. contributor: fullname: Spoerl – volume: 9 year: 2018 ident: bib38 article-title: An in vitro model for assessing corneal keratocyte spreading and migration on aligned fibrillar collagen publication-title: J. Funct. Biomater. contributor: fullname: Petroll – volume: 18 start-page: 24983 year: 2010 end-page: 24993 ident: bib76 article-title: Quantitative analysis of collagen fiber organization in injured tendons using Fourier transform-second harmonic generation imaging publication-title: Opt Express contributor: fullname: Toussaint – volume: 61 start-page: 28 year: 2020 ident: bib11 article-title: Fibrocytes, wound healing, and corneal fibrosis publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Wilson – volume: 8 year: 2018 ident: bib37 article-title: Assessment of corneal stromal remodeling and regeneration after photorefractive keratectomy publication-title: Sci. Rep. contributor: fullname: Petroll – volume: 6 start-page: 422 year: 2015 end-page: 438 ident: bib42 article-title: Human keratoconus cell contractility is mediated by transforming growth factor-beta isoforms publication-title: J. Funct. Biomater. contributor: fullname: Karamichos – volume: 52 start-page: 9275 year: 2011 end-page: 9278 ident: bib77 article-title: Cross-linking with ultraviolet-a and riboflavin reduces corneal permeability publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Lamy – volume: 41 start-page: 1 year: 2022 end-page: 11 ident: bib3 article-title: Keratoconus: diagnosis and staging publication-title: Cornea contributor: fullname: Borgstrom – volume: 14 year: 2022 ident: bib41 article-title: Nutritional and metabolic imbalance in keratoconus publication-title: Nutrients contributor: fullname: Ferrari – volume: 42 start-page: 297 year: 1998 end-page: 319 ident: bib67 article-title: Keratoconus publication-title: Surv. Ophthalmol. contributor: fullname: Rabinowitz – volume: 27 start-page: 401 year: 2011 end-page: 407 ident: bib71 article-title: Corneal wound healing after ultraviolet-A/riboflavin collagen cross-linking: a rabbit study publication-title: J. Refract. Surg. contributor: fullname: Wilson – volume: 177 start-page: 173 year: 2018 end-page: 180 ident: bib9 article-title: Collagen fiber crimping following in vivo UVA-induced corneal crosslinking publication-title: Exp. Eye Res. contributor: fullname: Jester – volume: 85 start-page: 305 year: 2007 end-page: 311 ident: bib87 article-title: Apoptosis in the initiation, modulation and termination of the corneal wound healing response publication-title: Exp. Eye Res. contributor: fullname: Medeiros – volume: 51 start-page: 864 year: 2010 end-page: 875 ident: bib34 article-title: Growth factor regulation of corneal keratocyte differentiation and migration in compressed collagen matrices publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Petroll – volume: 39 start-page: 487 year: 1998 end-page: 501 ident: bib54 article-title: Confocal microscopic characterization of wound repair after photorefractive keratectomy using in vivo confocal microscopy publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Jester – volume: 60 start-page: 459 year: 2015 end-page: 480 ident: bib58 article-title: Treatment options for advanced keratoconus: a review publication-title: Surv. Ophthalmol. contributor: fullname: Melles – volume: 44 start-page: 4237 year: 2003 end-page: 4246 ident: bib78 article-title: Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Fini – volume: 119 start-page: 1865 year: 2020 end-page: 1877 ident: bib45 article-title: ECM stiffness controls the activation and contractility of corneal keratocytes in response to TGF-beta1 publication-title: Biophys. J. contributor: fullname: Varner – volume: 24 start-page: 509 year: 2005 end-page: 522 ident: bib57 article-title: Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy publication-title: Cornea contributor: fullname: Wilson – volume: 79 start-page: 144 year: 2022 ident: bib85 article-title: Defective perlecan-associated basement membrane regeneration and altered modulation of transforming growth factor beta in corneal fibrosis publication-title: Cell. Mol. Life Sci. contributor: fullname: Wilson – volume: 35 start-page: 506 year: 2019 end-page: 516 ident: bib83 article-title: Coordinated modulation of corneal scarring by the epithelial basement membrane and descemet's basement membrane publication-title: J. Refract. Surg. contributor: fullname: Wilson – volume: 32 start-page: e36 year: 2013 end-page: e43 ident: bib65 article-title: Quantitative 3-dimensional corneal imaging in vivo using a modified HRT-RCM confocal microscope publication-title: Cornea contributor: fullname: Cavanagh – volume: 104 start-page: 360 year: 1997 end-page: 368 ident: bib55 article-title: Quantification of stromal thinning, epithelial thickness, and corneal haze after photorefractive keratectomy using in vivo confocal microscopy publication-title: Ophthalmology contributor: fullname: Jester – volume: 3 start-page: 183 year: 2012 end-page: 198 ident: bib62 article-title: Experimental models for investigating intra-stromal migration of corneal keratocytes, fibroblasts and myofibroblasts publication-title: J. Funct. Biomater. contributor: fullname: Ma – volume: 121 start-page: 469 year: 2014 end-page: 474 ident: bib32 article-title: In vivo confocal microscopy analyses of corneal microstructural changes in a prospective study of collagen cross-linking in keratoconus publication-title: Ophthalmology contributor: fullname: McGhee – volume: 17 start-page: 627 year: 1998 end-page: 639 ident: bib52 article-title: Corneal haze development after PRK is regulated by volume of stromal tissue removal publication-title: Cornea contributor: fullname: Jester – volume: 42 start-page: 1660 year: 2016 end-page: 1665 ident: bib8 article-title: Nonlinear optical corneal collagen crosslinking of ex vivo rabbit eyes publication-title: J. Cataract Refract. Surg. contributor: fullname: Jester – volume: 51 start-page: 1373 year: 2010 end-page: 1381 ident: bib66 article-title: Nanoscale topography-induced modulation of fundamental cell behaviors of rabbit corneal keratocytes, fibroblasts, and myofibroblasts publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Murphy – volume: 58 start-page: 291 year: 2017 end-page: 301 ident: bib69 article-title: Tissue and cellular biomechanics during corneal wound injury and repair publication-title: Acta Biomater. contributor: fullname: Murphy – volume: 40 start-page: 1959 year: 1999 end-page: 1967 ident: bib27 article-title: Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Cavanagh – volume: 7 year: 2017 ident: bib49 article-title: Differential effects of hormones on cellular metabolism in keratoconus in vitro publication-title: Sci. Rep. contributor: fullname: Karamichos – volume: 45 year: 2022 ident: bib73 article-title: Keratoconus: an updated review publication-title: Contact Lens Anterior Eye contributor: fullname: Wolffsohn – volume: 53 start-page: 811 year: 2012 end-page: 816 ident: bib56 article-title: Substratum topography modulates corneal fibroblast to myofibroblast transformation publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Murphy – volume: 135 start-page: 620 year: 2003 end-page: 627 ident: bib91 article-title: Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus publication-title: Am. J. Ophthalmol. contributor: fullname: Seiler – volume: 53 start-page: 770 year: 2012 end-page: 778 ident: bib26 article-title: Myofibroblast differentiation modulates keratocyte crystallin protein expression, concentration, and cellular light scattering publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Vasiliou – volume: 56 start-page: 7352 year: 2015 end-page: 7361 ident: bib61 article-title: Corneal fibroblast migration patterns during intrastromal wound healing correlate with ECM structure and alignment publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Graham – volume: 29 start-page: 412 year: 2010 end-page: 417 ident: bib13 article-title: Immunofluorescence of rabbit corneas after collagen cross-linking treatment with riboflavin and ultraviolet A publication-title: Cornea contributor: fullname: Bazan – volume: 52 start-page: 5325 year: 2011 end-page: 5331 ident: bib10 article-title: Multiphoton microscopy of ex vivo corneas after collagen cross-linking publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Artal – volume: 32 start-page: 1271 year: 2018 end-page: 1281 ident: bib75 article-title: Effects of collagen cross-linking on the keratoconus metabolic network publication-title: Eye contributor: fullname: Karamichos – volume: 8 start-page: 35 year: 2019 ident: bib7 article-title: Nonlinear optical corneal crosslinking, mechanical stiffening, and corneal flattening using amplified femtosecond pulses publication-title: Transl Vis Sci Technol contributor: fullname: Jester – volume: 17 start-page: 356 year: 2006 end-page: 360 ident: bib89 article-title: Crosslinking treatment of progressive keratoconus: new hope publication-title: Curr. Opin. Ophthalmol. contributor: fullname: Wollensak – volume: 35 start-page: 730 year: 1994 end-page: 743 ident: bib25 article-title: Corneal keratocytes: in situ and in vitro organization of cytoskeletal contractile proteins publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Cavanagh – volume: 200 year: 2020 ident: bib64 article-title: Keratocyte mechanobiology publication-title: Exp. Eye Res. contributor: fullname: Schmidtke – volume: 54 start-page: 378 year: 2013 end-page: 386 ident: bib68 article-title: Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Russell – volume: 153 start-page: 56 year: 2016 end-page: 64 ident: bib36 article-title: Temporal and spatial analysis of stromal cell and extracellular matrix patterning following lamellar keratectomy publication-title: Exp. Eye Res. contributor: fullname: Petroll – volume: 13 start-page: 187 year: 2015 end-page: 203 ident: bib63 article-title: In vivo confocal microscopy of the cornea: new developments in image acquisition, reconstruction, and analysis using the HRT-Rostock Corneal Module publication-title: Ocul. Surf. contributor: fullname: Robertson – volume: 38 start-page: 265 year: 2023 end-page: 274 ident: bib5 article-title: The evolution of diagnostics for keratoconus: from ophthalmometry to biomechanics publication-title: Semin. Ophthalmol. contributor: fullname: Vaddavalli – volume: 53 start-page: 1077 year: 2012 end-page: 1086 ident: bib39 article-title: Growth factor regulation of corneal keratocyte mechanical phenotypes in 3-D collagen matrices publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Petroll – volume: 87 start-page: 48 year: 2009 end-page: 51 ident: bib90 article-title: Long-term biomechanical properties of rabbit cornea after photodynamic collagen crosslinking publication-title: Acta Ophthalmol. contributor: fullname: Iomdina – volume: 111 start-page: 687 year: 2014 end-page: 692 ident: bib93 article-title: Three-dimensional aspects of matrix assembly by cells in the developing cornea publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Quantock – volume: 56 start-page: 2764 year: 2015 end-page: 2772 ident: bib88 article-title: A comparative study of vertebrate corneal structure: the evolution of a refractive lens publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Jester – volume: 39 start-page: 779 year: 2013 end-page: 788 ident: bib79 article-title: Characterizing the morphologic changes in collagen crosslinked-treated corneas by Fourier transform-second harmonic generation imaging publication-title: J. Cataract Refract. Surg. contributor: fullname: Dong – volume: 197 year: 2020 ident: bib84 article-title: Corneal wound healing publication-title: Exp. Eye Res. contributor: fullname: Wilson – volume: 33 start-page: 3271 year: 1992 end-page: 3282 ident: bib16 article-title: Radial keratotomy II: the role of the myofibroblast in corneal wound contraction publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Jester – volume: 107 start-page: 1235 year: 2000 end-page: 1245 ident: bib53 article-title: Stromal wound healing explains refractive instability and haze development after photorefractive keratectomy: a 1-year confocal microscopic study publication-title: Ophthalmology contributor: fullname: Jester – volume: 13 year: 2018 ident: bib74 article-title: Collagen cross-linking impact on keratoconus extracellular matrix publication-title: PLoS One contributor: fullname: Karamichos – volume: 49 start-page: 4377 year: 2008 end-page: 4383 ident: bib14 article-title: Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Jester – volume: 186 start-page: 301 year: 1995 end-page: 311 ident: bib29 article-title: Temporal, 3-dimensional, cellular anatomy of corneal wound tissue publication-title: J. Anat. contributor: fullname: Cavanagh – volume: 220 year: 2022 ident: bib23 article-title: ECM stiffness modulates the proliferation but not the motility of primary corneal keratocytes in response to PDGF-BB publication-title: Exp. Eye Res. contributor: fullname: Varner – volume: 13 start-page: 298 year: 2015 end-page: 314 ident: bib46 article-title: In vivo confocal microscopy after corneal collagen crosslinking publication-title: Ocul. Surf. contributor: fullname: Randleman – volume: 54 start-page: 5901 year: 2013 end-page: 5907 ident: bib12 article-title: Substratum compliance modulates corneal fibroblast to myofibroblast transformation publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Murphy – volume: 11 start-page: 9 year: 2022 ident: bib72 article-title: Topical losartan and corticosteroid additively inhibit corneal stromal myofibroblast generation and scarring fibrosis after alkali burn injury publication-title: Transl Vis Sci Technol contributor: fullname: Wilson – volume: 76 start-page: 71 year: 2003 end-page: 87 ident: bib51 article-title: Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK publication-title: Exp. Eye Res. contributor: fullname: Wilson – volume: 32 start-page: 111 year: 2013 end-page: 117 ident: bib50 article-title: Morphological and immunohistochemical changes after corneal cross-linking publication-title: Cornea contributor: fullname: Auw-Haedrich – volume: 18 start-page: 311 year: 1999 end-page: 356 ident: bib30 article-title: Corneal stromal wound healing in refractive surgery: the role of the myofibroblast publication-title: Prog. Retin. Eye Res. contributor: fullname: Cavanagh – volume: 36 start-page: 260 year: 2010 end-page: 264 ident: bib31 article-title: Evaluating corneal collagen organization using high-resolution nonlinear optical macroscopy publication-title: Eye Contact Lens contributor: fullname: Brown – volume: 6 year: 2016 ident: bib48 article-title: Endocrine and metabolic pathways linked to keratoconus: implications for the role of hormones in the stromal microenvironment publication-title: Sci. Rep. contributor: fullname: Karamichos – volume: 21 start-page: 99 year: 2019 ident: bib40 article-title: A high-throughput microfluidic method for fabricating aligned collagen fibrils to study Keratocyte behavior publication-title: Biomed. Microdevices contributor: fullname: Schmidtke – volume: 112 start-page: 613 year: 1999 end-page: 622 ident: bib28 article-title: The cellular basis of corneal transparency: evidence for 'corneal crystallins' publication-title: J. Cell Sci. contributor: fullname: Piatigorsky – volume: 44 start-page: 1879 year: 2003 end-page: 1887 ident: bib6 article-title: Connective tissue growth factor expression and action in human corneal fibroblast cultures and rat corneas after photorefractive keratectomy publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Schultz – volume: 2 start-page: 863 year: 2008 end-page: 867 ident: bib82 article-title: Collagen cross-linking: strengthening the unstable cornea publication-title: Clin. Ophthalmol. contributor: fullname: Garzozi – volume: 88 year: 2022 ident: bib33 article-title: Anterior pituitary, sex hormones, and keratoconus: beyond traditional targets publication-title: Prog. Retin. Eye Res. contributor: fullname: Riaz – volume: 175 start-page: 169 year: 2017 end-page: 172 ident: bib18 article-title: Age-specific incidence and prevalence of keratoconus: a nationwide registration study publication-title: Am. J. Ophthalmol. contributor: fullname: Wisse – volume: 109 start-page: 489 year: 2015 end-page: 500 ident: bib19 article-title: Dissecting collective cell behavior in polarization and alignment on micropatterned substrates publication-title: Biophys. J. contributor: fullname: Ji – volume: 35 start-page: 1638 year: 2016 end-page: 1643 ident: bib22 article-title: Matrix-based regenerating agent for corneal wound healing after collagen cross-linking publication-title: Cornea contributor: fullname: Guthoff – volume: 312 start-page: 3683 year: 2006 end-page: 3692 ident: bib35 article-title: Quantitative assessment of local collagen matrix remodeling in 3-D culture: the role of Rho kinase publication-title: Exp. Cell Res. contributor: fullname: Petroll – volume: 71A start-page: 369 year: 2004 end-page: 376 ident: bib81 article-title: Responses of human keratocytes to micro- and nanostructured substrates publication-title: J. Biomed. Mater. Res. contributor: fullname: Murphy – volume: 146 start-page: 527 year: 2008 end-page: 533 ident: bib47 article-title: Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications publication-title: Am. J. Ophthalmol. contributor: fullname: Caporossi – volume: 24 year: 2023 ident: bib1 article-title: Unravelling the impact of cyclic mechanical stretch in keratoconus-A transcriptomic profiling study publication-title: Int. J. Mol. Sci. contributor: fullname: Liu – volume: 18 start-page: 363 year: 2020 end-page: 373 ident: bib15 article-title: The keratoconus enigma: a review with emphasis on pathogenesis publication-title: Ocul. Surf. contributor: fullname: Rama – volume: 14 start-page: 64 year: 2019 end-page: 66 ident: bib60 article-title: Late onset corneal haze after corneal cross-linking for progressive keratoconus publication-title: Am J Ophthalmol Case Rep contributor: fullname: Parikakis – volume: 39 start-page: 451 year: 2013 end-page: 462 ident: bib4 article-title: Biomechanical properties of corneal tissue after ultraviolet-A-riboflavin crosslinking publication-title: J. Cataract Refract. Surg. contributor: fullname: Radhakrishnan – volume: 97 start-page: 357 year: 2009 end-page: 368 ident: bib17 article-title: Substrate topography induces a crossover from 2D to 3D behavior in fibroblast migration publication-title: Biophys. J. contributor: fullname: Ladoux – volume: 45 start-page: 1670 year: 2019 end-page: 1679 ident: bib2 article-title: Corneal crosslinking: current protocols and clinical approach publication-title: J. Cataract Refract. Surg. contributor: fullname: Committee – volume: 8 year: 2018 ident: bib24 article-title: Corneal myofibroblasts inhibit regenerating nerves during wound healing publication-title: Sci. Rep. contributor: fullname: Huxlin – volume: 48 start-page: 308 year: 2022 end-page: 312 ident: bib59 article-title: Temporal and spatial assessment of the corneal response to UV cross-linking using 3-dimensional in vivo confocal microscopy publication-title: Eye Contact Lens contributor: fullname: Petroll – volume: 39 start-page: 276 year: 1998 end-page: 283 ident: bib20 article-title: Keratocyte apoptosis after corneal surgery publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Wilson – volume: 39 start-page: 899 year: 2011 end-page: 909 ident: bib21 article-title: In vivo confocal laser-scanning microscopy to characterize wound repair in rabbit corneas after collagen cross-linking publication-title: Clin. Exp. Ophthalmol. contributor: fullname: Stachs – volume: 161 start-page: 101 year: 2017 end-page: 105 ident: bib43 article-title: Epithelial basement membrane injury and regeneration modulates corneal fibrosis after pseudomonas corneal ulcers in rabbits publication-title: Exp. Eye Res. contributor: fullname: Wilson – volume: 10 year: 2022 ident: bib44 article-title: Signaling downstream of focal adhesions regulates stiffness-dependent differences in the TGF-beta1-mediated myofibroblast differentiation of corneal keratocytes publication-title: Front. Cell Dev. Biol. contributor: fullname: Varner – volume: 23 start-page: 43 year: 2004 end-page: 49 ident: bib92 article-title: Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment publication-title: Cornea contributor: fullname: Seiler – volume: 116 start-page: 1881 year: 2003 end-page: 1892 ident: bib80 article-title: Epithelial contact guidance on well-defined micro- and nanostructured substrates publication-title: J. Cell Sci. contributor: fullname: Nealey – volume: 88 year: 2022 ident: 10.1016/j.exer.2023.109523_bib33 article-title: Anterior pituitary, sex hormones, and keratoconus: beyond traditional targets publication-title: Prog. Retin. Eye Res. doi: 10.1016/j.preteyeres.2021.101016 contributor: fullname: Karamichos – volume: 135 start-page: 620 year: 2003 ident: 10.1016/j.exer.2023.109523_bib91 article-title: Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus publication-title: Am. J. Ophthalmol. doi: 10.1016/S0002-9394(02)02220-1 contributor: fullname: Wollensak – volume: 119 start-page: 1865 year: 2020 ident: 10.1016/j.exer.2023.109523_bib45 article-title: ECM stiffness controls the activation and contractility of corneal keratocytes in response to TGF-beta1 publication-title: Biophys. J. doi: 10.1016/j.bpj.2020.08.040 contributor: fullname: Maruri – volume: 3 start-page: 183 year: 2012 ident: 10.1016/j.exer.2023.109523_bib62 article-title: Experimental models for investigating intra-stromal migration of corneal keratocytes, fibroblasts and myofibroblasts publication-title: J. Funct. Biomater. doi: 10.3390/jfb3010183 contributor: fullname: Petroll – volume: 87 start-page: 48 year: 2009 ident: 10.1016/j.exer.2023.109523_bib90 article-title: Long-term biomechanical properties of rabbit cornea after photodynamic collagen crosslinking publication-title: Acta Ophthalmol. doi: 10.1111/j.1755-3768.2008.01190.x contributor: fullname: Wollensak – volume: 39 start-page: 899 year: 2011 ident: 10.1016/j.exer.2023.109523_bib21 article-title: In vivo confocal laser-scanning microscopy to characterize wound repair in rabbit corneas after collagen cross-linking publication-title: Clin. Exp. Ophthalmol. doi: 10.1111/j.1442-9071.2011.02634.x contributor: fullname: Hovakimyan – volume: 186 start-page: 301 issue: Pt 2 year: 1995 ident: 10.1016/j.exer.2023.109523_bib29 article-title: Temporal, 3-dimensional, cellular anatomy of corneal wound tissue publication-title: J. Anat. contributor: fullname: Jester – volume: 58 start-page: 291 year: 2017 ident: 10.1016/j.exer.2023.109523_bib69 article-title: Tissue and cellular biomechanics during corneal wound injury and repair publication-title: Acta Biomater. doi: 10.1016/j.actbio.2017.05.051 contributor: fullname: Raghunathan – volume: 7 year: 2017 ident: 10.1016/j.exer.2023.109523_bib49 article-title: Differential effects of hormones on cellular metabolism in keratoconus in vitro publication-title: Sci. Rep. doi: 10.1038/srep42896 contributor: fullname: McKay – volume: 13 start-page: 298 year: 2015 ident: 10.1016/j.exer.2023.109523_bib46 article-title: In vivo confocal microscopy after corneal collagen crosslinking publication-title: Ocul. Surf. doi: 10.1016/j.jtos.2015.04.007 contributor: fullname: Mazzotta – volume: 24 year: 2023 ident: 10.1016/j.exer.2023.109523_bib1 article-title: Unravelling the impact of cyclic mechanical stretch in keratoconus-A transcriptomic profiling study publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms24087437 contributor: fullname: Akoto – volume: 13 start-page: 187 year: 2015 ident: 10.1016/j.exer.2023.109523_bib63 article-title: In vivo confocal microscopy of the cornea: new developments in image acquisition, reconstruction, and analysis using the HRT-Rostock Corneal Module publication-title: Ocul. Surf. doi: 10.1016/j.jtos.2015.05.002 contributor: fullname: Petroll – volume: 27 start-page: 401 year: 2011 ident: 10.1016/j.exer.2023.109523_bib71 article-title: Corneal wound healing after ultraviolet-A/riboflavin collagen cross-linking: a rabbit study publication-title: J. Refract. Surg. doi: 10.3928/1081597X-20101201-02 contributor: fullname: Salomao – volume: 79 start-page: 144 year: 2022 ident: 10.1016/j.exer.2023.109523_bib85 article-title: Defective perlecan-associated basement membrane regeneration and altered modulation of transforming growth factor beta in corneal fibrosis publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-022-04184-7 contributor: fullname: Wilson – volume: 18 start-page: 311 year: 1999 ident: 10.1016/j.exer.2023.109523_bib30 article-title: Corneal stromal wound healing in refractive surgery: the role of the myofibroblast publication-title: Prog. Retin. Eye Res. doi: 10.1016/S1350-9462(98)00021-4 contributor: fullname: Jester – volume: 53 start-page: 770 year: 2012 ident: 10.1016/j.exer.2023.109523_bib26 article-title: Myofibroblast differentiation modulates keratocyte crystallin protein expression, concentration, and cellular light scattering publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-9092 contributor: fullname: Jester – volume: 51 start-page: 1373 year: 2010 ident: 10.1016/j.exer.2023.109523_bib66 article-title: Nanoscale topography-induced modulation of fundamental cell behaviors of rabbit corneal keratocytes, fibroblasts, and myofibroblasts publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.09-4074 contributor: fullname: Pot – volume: 112 start-page: 613 year: 1999 ident: 10.1016/j.exer.2023.109523_bib28 article-title: The cellular basis of corneal transparency: evidence for 'corneal crystallins' publication-title: J. Cell Sci. doi: 10.1242/jcs.112.5.613 contributor: fullname: Jester – volume: 14 start-page: 64 year: 2019 ident: 10.1016/j.exer.2023.109523_bib60 article-title: Late onset corneal haze after corneal cross-linking for progressive keratoconus publication-title: Am J Ophthalmol Case Rep doi: 10.1016/j.ajoc.2019.02.008 contributor: fullname: Peponis – volume: 197 year: 2020 ident: 10.1016/j.exer.2023.109523_bib84 article-title: Corneal wound healing publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2020.108089 contributor: fullname: Wilson – volume: 56 start-page: 2764 year: 2015 ident: 10.1016/j.exer.2023.109523_bib88 article-title: A comparative study of vertebrate corneal structure: the evolution of a refractive lens publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.15-16584 contributor: fullname: Winkler – volume: 32 start-page: 1271 year: 2018 ident: 10.1016/j.exer.2023.109523_bib75 article-title: Effects of collagen cross-linking on the keratoconus metabolic network publication-title: Eye doi: 10.1038/s41433-018-0075-6 contributor: fullname: Sharif – volume: 116 start-page: 1881 year: 2003 ident: 10.1016/j.exer.2023.109523_bib80 article-title: Epithelial contact guidance on well-defined micro- and nanostructured substrates publication-title: J. Cell Sci. doi: 10.1242/jcs.00383 contributor: fullname: Teixeira – volume: 36 start-page: 260 year: 2010 ident: 10.1016/j.exer.2023.109523_bib31 article-title: Evaluating corneal collagen organization using high-resolution nonlinear optical macroscopy publication-title: Eye Contact Lens doi: 10.1097/ICL.0b013e3181ee8992 contributor: fullname: Jester – year: 2022 ident: 10.1016/j.exer.2023.109523_bib86 contributor: fullname: Wilson – volume: 312 start-page: 3683 year: 2006 ident: 10.1016/j.exer.2023.109523_bib35 article-title: Quantitative assessment of local collagen matrix remodeling in 3-D culture: the role of Rho kinase publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2006.08.009 contributor: fullname: Kim – volume: 39 start-page: 276 year: 1998 ident: 10.1016/j.exer.2023.109523_bib20 article-title: Keratocyte apoptosis after corneal surgery publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Helena – volume: 220 year: 2022 ident: 10.1016/j.exer.2023.109523_bib23 article-title: ECM stiffness modulates the proliferation but not the motility of primary corneal keratocytes in response to PDGF-BB publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2022.109112 contributor: fullname: Iyer – volume: 42 start-page: 1660 year: 2016 ident: 10.1016/j.exer.2023.109523_bib8 article-title: Nonlinear optical corneal collagen crosslinking of ex vivo rabbit eyes publication-title: J. Cataract Refract. Surg. doi: 10.1016/j.jcrs.2016.06.040 contributor: fullname: Bradford – volume: 97 start-page: 357 year: 2009 ident: 10.1016/j.exer.2023.109523_bib17 article-title: Substrate topography induces a crossover from 2D to 3D behavior in fibroblast migration publication-title: Biophys. J. doi: 10.1016/j.bpj.2009.04.024 contributor: fullname: Ghibaudo – volume: 17 start-page: 356 year: 2006 ident: 10.1016/j.exer.2023.109523_bib89 article-title: Crosslinking treatment of progressive keratoconus: new hope publication-title: Curr. Opin. Ophthalmol. doi: 10.1097/01.icu.0000233954.86723.25 contributor: fullname: Wollensak – volume: 32 start-page: 111 year: 2013 ident: 10.1016/j.exer.2023.109523_bib50 article-title: Morphological and immunohistochemical changes after corneal cross-linking publication-title: Cornea doi: 10.1097/ICO.0b013e31824d701b contributor: fullname: Messmer – volume: 8 year: 2018 ident: 10.1016/j.exer.2023.109523_bib37 article-title: Assessment of corneal stromal remodeling and regeneration after photorefractive keratectomy publication-title: Sci. Rep. doi: 10.1038/s41598-018-30372-2 contributor: fullname: Kivanany – volume: 29 start-page: 412 year: 2010 ident: 10.1016/j.exer.2023.109523_bib13 article-title: Immunofluorescence of rabbit corneas after collagen cross-linking treatment with riboflavin and ultraviolet A publication-title: Cornea doi: 10.1097/ICO.0b013e3181bdf1cc contributor: fullname: Esquenazi – volume: 42 start-page: 297 year: 1998 ident: 10.1016/j.exer.2023.109523_bib67 article-title: Keratoconus publication-title: Surv. Ophthalmol. doi: 10.1016/S0039-6257(97)00119-7 contributor: fullname: Rabinowitz – volume: 52 start-page: 9275 year: 2011 ident: 10.1016/j.exer.2023.109523_bib77 article-title: Cross-linking with ultraviolet-a and riboflavin reduces corneal permeability publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-8155 contributor: fullname: Stewart – volume: 11 start-page: 9 year: 2022 ident: 10.1016/j.exer.2023.109523_bib72 article-title: Topical losartan and corticosteroid additively inhibit corneal stromal myofibroblast generation and scarring fibrosis after alkali burn injury publication-title: Transl Vis Sci Technol doi: 10.1167/tvst.11.7.9 contributor: fullname: Sampaio – volume: 177 start-page: 173 year: 2018 ident: 10.1016/j.exer.2023.109523_bib9 article-title: Collagen fiber crimping following in vivo UVA-induced corneal crosslinking publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2018.08.009 contributor: fullname: Bradford – volume: 45 year: 2022 ident: 10.1016/j.exer.2023.109523_bib73 article-title: Keratoconus: an updated review publication-title: Contact Lens Anterior Eye doi: 10.1016/j.clae.2021.101559 contributor: fullname: Santodomingo-Rubido – volume: 49 start-page: 4377 year: 2008 ident: 10.1016/j.exer.2023.109523_bib14 article-title: Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.08-1983 contributor: fullname: Farid – volume: 38 start-page: 265 year: 2023 ident: 10.1016/j.exer.2023.109523_bib5 article-title: The evolution of diagnostics for keratoconus: from ophthalmometry to biomechanics publication-title: Semin. Ophthalmol. doi: 10.1080/08820538.2022.2152716 contributor: fullname: Bevara – volume: 54 start-page: 5901 year: 2013 ident: 10.1016/j.exer.2023.109523_bib12 article-title: Substratum compliance modulates corneal fibroblast to myofibroblast transformation publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-11575 contributor: fullname: Dreier – volume: 71A start-page: 369 year: 2004 ident: 10.1016/j.exer.2023.109523_bib81 article-title: Responses of human keratocytes to micro- and nanostructured substrates publication-title: J. Biomed. Mater. Res. doi: 10.1002/jbm.a.30089 contributor: fullname: Teixeira – volume: 52 start-page: 5325 year: 2011 ident: 10.1016/j.exer.2023.109523_bib10 article-title: Multiphoton microscopy of ex vivo corneas after collagen cross-linking publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-7184 contributor: fullname: Bueno – volume: 44 start-page: 4237 year: 2003 ident: 10.1016/j.exer.2023.109523_bib78 article-title: Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.02-1188 contributor: fullname: Stramer – volume: 53 start-page: 811 year: 2012 ident: 10.1016/j.exer.2023.109523_bib56 article-title: Substratum topography modulates corneal fibroblast to myofibroblast transformation publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-7982 contributor: fullname: Myrna – volume: 35 start-page: 506 year: 2019 ident: 10.1016/j.exer.2023.109523_bib83 article-title: Coordinated modulation of corneal scarring by the epithelial basement membrane and descemet's basement membrane publication-title: J. Refract. Surg. doi: 10.3928/1081597X-20190625-02 contributor: fullname: Wilson – volume: 24 start-page: 509 year: 2005 ident: 10.1016/j.exer.2023.109523_bib57 article-title: Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy publication-title: Cornea doi: 10.1097/01.ico.0000151544.23360.17 contributor: fullname: Netto – volume: 41 start-page: 1 year: 2022 ident: 10.1016/j.exer.2023.109523_bib3 article-title: Keratoconus: diagnosis and staging publication-title: Cornea doi: 10.1097/ICO.0000000000002781 contributor: fullname: Belin – volume: 61 start-page: 28 year: 2020 ident: 10.1016/j.exer.2023.109523_bib11 article-title: Fibrocytes, wound healing, and corneal fibrosis publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.61.2.28 contributor: fullname: de Oliveira – volume: 44 start-page: 1879 year: 2003 ident: 10.1016/j.exer.2023.109523_bib6 article-title: Connective tissue growth factor expression and action in human corneal fibroblast cultures and rat corneas after photorefractive keratectomy publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.02-0860 contributor: fullname: Blalock – volume: 54 start-page: 378 year: 2013 ident: 10.1016/j.exer.2023.109523_bib68 article-title: Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-11007 contributor: fullname: Raghunathan – volume: 17 start-page: 627 year: 1998 ident: 10.1016/j.exer.2023.109523_bib52 article-title: Corneal haze development after PRK is regulated by volume of stromal tissue removal publication-title: Cornea doi: 10.1097/00003226-199811000-00011 contributor: fullname: Moller-Pedersen – volume: 121 start-page: 469 year: 2014 ident: 10.1016/j.exer.2023.109523_bib32 article-title: In vivo confocal microscopy analyses of corneal microstructural changes in a prospective study of collagen cross-linking in keratoconus publication-title: Ophthalmology doi: 10.1016/j.ophtha.2013.09.014 contributor: fullname: Jordan – volume: 40 start-page: 1959 year: 1999 ident: 10.1016/j.exer.2023.109523_bib27 article-title: Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Jester – volume: 53 start-page: 1077 year: 2012 ident: 10.1016/j.exer.2023.109523_bib39 article-title: Growth factor regulation of corneal keratocyte mechanical phenotypes in 3-D collagen matrices publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-8609 contributor: fullname: Lakshman – volume: 8 year: 2018 ident: 10.1016/j.exer.2023.109523_bib24 article-title: Corneal myofibroblasts inhibit regenerating nerves during wound healing publication-title: Sci. Rep. doi: 10.1038/s41598-018-30964-y contributor: fullname: Jeon – volume: 175 start-page: 169 year: 2017 ident: 10.1016/j.exer.2023.109523_bib18 article-title: Age-specific incidence and prevalence of keratoconus: a nationwide registration study publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2016.12.015 contributor: fullname: Godefrooij – volume: 25 start-page: S824 year: 2009 ident: 10.1016/j.exer.2023.109523_bib70 article-title: Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus publication-title: J. Refract. Surg. doi: 10.3928/1081597X-20090813-12 contributor: fullname: Raiskup – volume: 45 start-page: 1670 year: 2019 ident: 10.1016/j.exer.2023.109523_bib2 article-title: Corneal crosslinking: current protocols and clinical approach publication-title: J. Cataract Refract. Surg. doi: 10.1016/j.jcrs.2019.06.027 contributor: fullname: Beckman – volume: 200 year: 2020 ident: 10.1016/j.exer.2023.109523_bib64 article-title: Keratocyte mechanobiology publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2020.108228 contributor: fullname: Petroll – volume: 85 start-page: 305 year: 2007 ident: 10.1016/j.exer.2023.109523_bib87 article-title: Apoptosis in the initiation, modulation and termination of the corneal wound healing response publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2007.06.009 contributor: fullname: Wilson – volume: 10 year: 2022 ident: 10.1016/j.exer.2023.109523_bib44 article-title: Signaling downstream of focal adhesions regulates stiffness-dependent differences in the TGF-beta1-mediated myofibroblast differentiation of corneal keratocytes publication-title: Front. Cell Dev. Biol. doi: 10.3389/fcell.2022.886759 contributor: fullname: Maruri – volume: 35 start-page: 1638 year: 2016 ident: 10.1016/j.exer.2023.109523_bib22 article-title: Matrix-based regenerating agent for corneal wound healing after collagen cross-linking publication-title: Cornea doi: 10.1097/ICO.0000000000001047 contributor: fullname: Hovakimyan – volume: 9 year: 2018 ident: 10.1016/j.exer.2023.109523_bib38 article-title: An in vitro model for assessing corneal keratocyte spreading and migration on aligned fibrillar collagen publication-title: J. Funct. Biomater. doi: 10.3390/jfb9040054 contributor: fullname: Kivanany – volume: 21 start-page: 99 year: 2019 ident: 10.1016/j.exer.2023.109523_bib40 article-title: A high-throughput microfluidic method for fabricating aligned collagen fibrils to study Keratocyte behavior publication-title: Biomed. Microdevices doi: 10.1007/s10544-019-0436-3 contributor: fullname: Lam – volume: 48 start-page: 308 year: 2022 ident: 10.1016/j.exer.2023.109523_bib59 article-title: Temporal and spatial assessment of the corneal response to UV cross-linking using 3-dimensional in vivo confocal microscopy publication-title: Eye Contact Lens doi: 10.1097/ICL.0000000000000892 contributor: fullname: Parsa – volume: 111 start-page: 687 year: 2014 ident: 10.1016/j.exer.2023.109523_bib93 article-title: Three-dimensional aspects of matrix assembly by cells in the developing cornea publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1313561110 contributor: fullname: Young – volume: 18 start-page: 24983 year: 2010 ident: 10.1016/j.exer.2023.109523_bib76 article-title: Quantitative analysis of collagen fiber organization in injured tendons using Fourier transform-second harmonic generation imaging publication-title: Opt Express doi: 10.1364/OE.18.024983 contributor: fullname: Sivaguru – volume: 6 year: 2016 ident: 10.1016/j.exer.2023.109523_bib48 article-title: Endocrine and metabolic pathways linked to keratoconus: implications for the role of hormones in the stromal microenvironment publication-title: Sci. Rep. doi: 10.1038/srep25534 contributor: fullname: McKay – volume: 35 start-page: 730 year: 1994 ident: 10.1016/j.exer.2023.109523_bib25 article-title: Corneal keratocytes: in situ and in vitro organization of cytoskeletal contractile proteins publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Jester – volume: 161 start-page: 101 year: 2017 ident: 10.1016/j.exer.2023.109523_bib43 article-title: Epithelial basement membrane injury and regeneration modulates corneal fibrosis after pseudomonas corneal ulcers in rabbits publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2017.05.003 contributor: fullname: Marino – volume: 51 start-page: 864 year: 2010 ident: 10.1016/j.exer.2023.109523_bib34 article-title: Growth factor regulation of corneal keratocyte differentiation and migration in compressed collagen matrices publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.09-4200 contributor: fullname: Kim – volume: 14 year: 2022 ident: 10.1016/j.exer.2023.109523_bib41 article-title: Nutritional and metabolic imbalance in keratoconus publication-title: Nutrients doi: 10.3390/nu14040913 contributor: fullname: Lasagni Vitar – volume: 107 start-page: 1235 year: 2000 ident: 10.1016/j.exer.2023.109523_bib53 article-title: Stromal wound healing explains refractive instability and haze development after photorefractive keratectomy: a 1-year confocal microscopic study publication-title: Ophthalmology doi: 10.1016/S0161-6420(00)00142-1 contributor: fullname: Moller-Pedersen – volume: 18 start-page: 363 year: 2020 ident: 10.1016/j.exer.2023.109523_bib15 article-title: The keratoconus enigma: a review with emphasis on pathogenesis publication-title: Ocul. Surf. doi: 10.1016/j.jtos.2020.03.006 contributor: fullname: Ferrari – volume: 60 start-page: 459 year: 2015 ident: 10.1016/j.exer.2023.109523_bib58 article-title: Treatment options for advanced keratoconus: a review publication-title: Surv. Ophthalmol. doi: 10.1016/j.survophthal.2015.02.004 contributor: fullname: Parker – volume: 39 start-page: 779 year: 2013 ident: 10.1016/j.exer.2023.109523_bib79 article-title: Characterizing the morphologic changes in collagen crosslinked-treated corneas by Fourier transform-second harmonic generation imaging publication-title: J. Cataract Refract. Surg. doi: 10.1016/j.jcrs.2012.11.036 contributor: fullname: Tan – volume: 153 start-page: 56 year: 2016 ident: 10.1016/j.exer.2023.109523_bib36 article-title: Temporal and spatial analysis of stromal cell and extracellular matrix patterning following lamellar keratectomy publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2016.10.009 contributor: fullname: Kivanany – volume: 39 start-page: 451 year: 2013 ident: 10.1016/j.exer.2023.109523_bib4 article-title: Biomechanical properties of corneal tissue after ultraviolet-A-riboflavin crosslinking publication-title: J. Cataract Refract. Surg. doi: 10.1016/j.jcrs.2013.01.026 contributor: fullname: Beshtawi – volume: 104 start-page: 360 year: 1997 ident: 10.1016/j.exer.2023.109523_bib55 article-title: Quantification of stromal thinning, epithelial thickness, and corneal haze after photorefractive keratectomy using in vivo confocal microscopy publication-title: Ophthalmology doi: 10.1016/S0161-6420(97)30307-8 contributor: fullname: Moller-Pedersen – volume: 23 start-page: 43 year: 2004 ident: 10.1016/j.exer.2023.109523_bib92 article-title: Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment publication-title: Cornea doi: 10.1097/00003226-200401000-00008 contributor: fullname: Wollensak – volume: 6 start-page: 422 year: 2015 ident: 10.1016/j.exer.2023.109523_bib42 article-title: Human keratoconus cell contractility is mediated by transforming growth factor-beta isoforms publication-title: J. Funct. Biomater. doi: 10.3390/jfb6020422 contributor: fullname: Lyon – volume: 146 start-page: 527 year: 2008 ident: 10.1016/j.exer.2023.109523_bib47 article-title: Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2008.05.042 contributor: fullname: Mazzotta – volume: 76 start-page: 71 year: 2003 ident: 10.1016/j.exer.2023.109523_bib51 article-title: Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK publication-title: Exp. Eye Res. doi: 10.1016/S0014-4835(02)00251-8 contributor: fullname: Mohan – volume: 33 start-page: 3271 year: 1992 ident: 10.1016/j.exer.2023.109523_bib16 article-title: Radial keratotomy II: the role of the myofibroblast in corneal wound contraction publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Garana – volume: 8 start-page: 35 year: 2019 ident: 10.1016/j.exer.2023.109523_bib7 article-title: Nonlinear optical corneal crosslinking, mechanical stiffening, and corneal flattening using amplified femtosecond pulses publication-title: Transl Vis Sci Technol doi: 10.1167/tvst.8.6.35 contributor: fullname: Bradford – volume: 109 start-page: 489 year: 2015 ident: 10.1016/j.exer.2023.109523_bib19 article-title: Dissecting collective cell behavior in polarization and alignment on micropatterned substrates publication-title: Biophys. J. doi: 10.1016/j.bpj.2015.06.058 contributor: fullname: He – volume: 39 start-page: 487 year: 1998 ident: 10.1016/j.exer.2023.109523_bib54 article-title: Confocal microscopic characterization of wound repair after photorefractive keratectomy using in vivo confocal microscopy publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Moller-Pedersen – volume: 32 start-page: e36 year: 2013 ident: 10.1016/j.exer.2023.109523_bib65 article-title: Quantitative 3-dimensional corneal imaging in vivo using a modified HRT-RCM confocal microscope publication-title: Cornea doi: 10.1097/ICO.0b013e31825ec44e contributor: fullname: Petroll – volume: 13 year: 2018 ident: 10.1016/j.exer.2023.109523_bib74 article-title: Collagen cross-linking impact on keratoconus extracellular matrix publication-title: PLoS One doi: 10.1371/journal.pone.0200704 contributor: fullname: Sharif – volume: 2 start-page: 863 year: 2008 ident: 10.1016/j.exer.2023.109523_bib82 article-title: Collagen cross-linking: strengthening the unstable cornea publication-title: Clin. Ophthalmol. doi: 10.2147/OPTH.S2800 contributor: fullname: Tomkins – volume: 56 start-page: 7352 year: 2015 ident: 10.1016/j.exer.2023.109523_bib61 article-title: Corneal fibroblast migration patterns during intrastromal wound healing correlate with ECM structure and alignment publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.15-17978 contributor: fullname: Petroll |
SSID | ssj0003474 |
Score | 2.431599 |
Snippet | Previous studies have demonstrated that UV cross-linking (CXL) increases stromal stiffness and produces alterations in extracellular matrix (ECM)... |
SourceID | pubmedcentral proquest crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 109523 |
SubjectTerms | Actins - metabolism Animals Cell Differentiation Cell Movement Confocal microscopy Corneal cross-linking Corneal Stroma - metabolism Corneal wound healing Cross-Linking Reagents - pharmacology Extracellular matrix Fibrosis Photorefractive Keratectomy Rabbits Second harmonic generation imaging Wound Healing |
Title | The impact of UV cross-linking on corneal stromal cell migration, differentiation and patterning |
URI | https://dx.doi.org/10.1016/j.exer.2023.109523 https://www.ncbi.nlm.nih.gov/pubmed/37271309 https://www.proquest.com/docview/2822706051/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC10825899 |
Volume | 233 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB61WwlxQdDy2AKVkRAXSJvEjzjHVUW1gNoTi3ozTmyXRVpn1aaHXvjteGJnxYLgwCnvaOSZzCsz3wC85sZWIq9NxoRkGTPSZbotq8w49N-NNnzIQ55fiPmCfbzklztwOvbCYFll0v1Rpw_aOp05Sat5sl4uscc3BAPoQNBhT-zCXjBHjE1gb_bh0_xio5ApS2DMBcPcGU-9M7HMCycbHeMMcQRW4iX9m3360__8vYzyF7t09hAeJIeSzCLNj2DH-n04mPkQTK_uyBsylHgOufN9uHee_qQfwNcgHyS2SJLOkcUXMtCTpVkKpPMkxKU-uJHkpr_uVmGLOX6yWl5FmXlHxtkqfeQu0d6Q9QDXibmWx7A4e__5dJ6laQtZSwXts9Y4lhtOWe5qgxgytLKWyULLsi4rGSKbVjPGc6Fry4yoXAjNdNNQV7aWW8noE5j4zttnQGpJ8ya8rRThJuu4bKumdaxpuTRC82oKb8c1VusIqqHGarPvCjmikCMqcmQKfGSD2hINFbT-P597NfJMhW8GF0l7293eKCydRdQgXkzhaeThhg4aHLpg1-spyC3ubm5APO7tK375bcDlLjDcDvHr4X8S_Bzu41EsL3wBk_761r4MLk_fHMHu8Y_iKAn2Tx1XATM |
link.rule.ids | 230,315,786,790,891,4521,24144,27957,27958,45620,45714 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB2VrQRcELRQlk8jIS4QmsR24hxXFdWWdvfURb0ZJ7bpIq2zatMD_x5P7Ky6VHDglChOopGfM56ZzLwBeM-1KYu00gkrBEuYFjZRTV4m2qL9rpXmfRxyNi-mC_b1gl_swNFQC4NplVH3B53ea-t45TDO5uF6ucQaX-8MoAFB-7PiHuwyXmZsBLuTk9PpfKOQKYtkzBnD2BmPtTMhzQs7G33GHuJIrMRz-rf96a79-Wca5a196fgxPIoGJZkEmZ_AjnF7sD9x3ple_SIfSJ_i2cfO9-D-LP5J34fvfn2QUCJJWksW30gvTxJ7KZDWEe-XOm9Gkuvuql35I8b4yWr5I6yZT2TordIFdIlymqx7uk6MtTyFxfGX86NpErstJA0taJc02rJUc8pSW2nkkKGlMUxkSuRVXgrv2TSKMZ4WqjJMF6X1rpmqa2rzxnAjGH0GI9c68xxIJWha-7flhb_JWC6asm4sqxsudKF4OYaPwxzLdSDVkEO22U-JiEhERAZExsAHGOTW0pBe6__zuXcDZtJ_MzhJypn25lpi6iyyBvFsDAcBw40c1Bt0fl-vxiC20N3cgHzc2yNuednzcmfobnv_9cV_CvwWHkzPZ2fy7GR--hIe4khINXwFo-7qxrz25k9Xv4nL-zdO4AMl |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+impact+of+UV+cross-linking+on+corneal+stromal+cell+migration%2C+differentiation+and+patterning&rft.jtitle=Experimental+eye+research&rft.au=Petroll%2C+W.+Matthew&rft.au=Miron-Mendoza%2C+Miguel&rft.au=Sunkara%2C+Yukta&rft.au=Ikebe%2C+Hikaru+R.&rft.date=2023-08-01&rft.issn=0014-4835&rft.volume=233&rft.spage=109523&rft_id=info:doi/10.1016%2Fj.exer.2023.109523&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_exer_2023_109523 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-4835&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-4835&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-4835&client=summon |