Multiple mechanisms of ontogenic regulation of nuclear receptors during rat liver development

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 288; no. 2; pp. G251 - G260
• Main Authors: Balasubramaniyan, N, Shahid, Mohammad, Suchy, Frederick J, Ananthanarayanan, M
• Format: Journal Article
• Language: English
• Published: United States 01.02.2005
• Subjects: Animals; Female; Gene Expression Regulation, Developmental - physiology; Liver - embryology; Liver - growth & development; Liver - metabolism; Male; Rats; Receptors, Cytoplasmic and Nuclear - biosynthesis; RNA, Messenger - metabolism

Nuclear receptors (NRs) play pivotal roles in the regulation of genes contributing to hepatobiliary cholesterol and bile acid homeostasis. We have previously shown that transporters involved in bile formation are developmentally regulated and are poorly developed during the fetal stage, but their ex...