Omentin-1 enhances the inhibitory effect of endothelial progenitor cells on neointimal hyperplasia by inhibiting the p38 MAPK/CREB pathway

• Published in: Life sciences (1973) Vol. 331; p. 122061
• Main Authors: Xiang, Yuan, Zhou, Zhengshi, Zhu, Lingping, Li, Chuanchang, Luo, Ying, Zhou, Jipeng
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.10.2023
• Subjects: Adenoviridae; agonists; anti-inflammatory activity; apoptosis; carotid arteries; caudal vein; Coronary heart disease; Endothelial progenitor cells; green fluorescent protein; humans; hyperplasia; immunohistochemistry; Inflammation; mitogen-activated protein kinase; necrosis; neoplasms; Omentin-1; Restenosis; Restenosis; Inflammation; Omentin-1; Coronary heart disease; Endothelial progenitor cells

Endothelial progenitor cells (EPCs) play an important role in vascular repair. However, they are dysfunctional in the inflammatory microenvironment during restenosis. In this study, we investigated whether omentin-1, an anti-inflammatory factor, could reduce neointima formation after carotid artery...