Tangeretin, a polymethoxylated flavone, modulates lipid homeostasis and decreases oxidative stress by inhibiting NF-κB activation and proinflammatory cytokines in cardiac tissue of streptozotocin-induced diabetic rats

• Published in: Journal of functional foods Vol. 16; pp. 315 - 333
• Main Authors: Sundaram, Ramalingam, Shanthi, Palanivelu, Sachdanandam, Panchanatham
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.2015; Elsevier
• Subjects: Cardiovascular disease; Diabetes; Inflammation; Tangeretin; CRP; HP; Cardiovascular disease; LPL; LCAT; LPO; MDA; PMFs; LDH; TBS-T; STZ; VLDL-c; NF-kBp65; AST; HMG; SDS; PUFA; LDL-c; SOD; GST; Inflammation; TBARS; GR; EDTA; IL-6; TNF-α; ROS; CAT; TGL; Diabetes; GLUT4; Tangeretin; CPK

•Effect of tangeretin on lipid metabolism and cardiac abnormalities in diabetic rats.•Streptozotocin damages the pancreatic β cells and decreases insulin secretion.•Lack of insulin, lipid metabolizing enzymes and cardiac enzymes altered.•Tangeretin treatment enhances the insulin secretion and normal...