Paraneoplastic syndrome of non-small cell lung carcinoma: A case with pancytopenia, leukocytoclastic vasculitis, and hypertrophic osteoarthropathy

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 56; no. 3; pp. 455 - 458
• Main Authors: Cosar-Alas, Rusen, Yurut-Caloglu, Vuslat, Karagol, Hakan, Caloglu, Murat, Yalcin, Omer, Turgut, Burhan, Saynak, Mert, Uzal, Cem
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.06.2007; Elsevier Science
• Subjects: Aged; Biological and medical sciences; Biopsy, Needle; Carcinoma, Non-Small-Cell Lung - complications; Carcinoma, Non-Small-Cell Lung - diagnosis; Diagnosis, Differential; Fatal Outcome; Follow-Up Studies; Hematologic and hematopoietic diseases; Hematology, Oncology and Palliative Medicine; Humans; Hypertrophic pulmonary osteoarthropathy; Leokocytolastic vasculitis; Lung Neoplasms - complications; Lung Neoplasms - diagnosis; Male; Medical sciences; Non-small cell lung carcinoma; Osteoarthropathy, Secondary Hypertrophic - diagnosis; Osteoarthropathy, Secondary Hypertrophic - etiology; Other diseases. Hematologic involvement in other diseases; Pancytopenia; Pancytopenia - diagnosis; Pancytopenia - etiology; Paraneoplastic Syndromes; Pneumology; Pulmonary/Respiratory; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Tomography, X-Ray Computed; Tumors; Tumors of the respiratory system and mediastinum; Vasculitis, Leukocytoclastic, Cutaneous - diagnosis; Vasculitis, Leukocytoclastic, Cutaneous - etiology; Hypertrophic pulmonary osteoarthropathy; Non-small cell lung carcinoma; Paraneoplastic syndromes; Pancytopenia; Leokocytolastic vasculitis; Lung disease; Skin disease; Leucocytoclastic vasculitis; Respiratory disease; Hypertrophic pulmonary arthropathy; Diseases of the osteoarticular system; Cardiovascular disease; Hemopathy; Malignant tumor; non-small cell lung carcinoma; Vascular disease; Case study; Cancerology; Bronchus disease; Paraneoplastic syndrome; Pneumology
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/j.lungcan.2007.01.008

Summary Various remote effects of cancer or paraneoplastic syndromes (PNS) are common in lung cancer, and may be the manifestation of the disease or its recurrence. The symptoms may be endocrine, neuromuscular or musculoskeletal, cardiovascular, cutaneous, hematologic, gastrointestinal, renal, or miscellaneous in nature. Since the symptoms of paraneoplastic syndromes may occur before the local symptoms of the primary tumor, it might be helpful in the early diagnosis of malignancy. We present a 65-year-old man with multiple paraneoplastic syndrome forms consisting of pancytopenia leukocytoclastic vasculitis and hypertrophic pulmonary osteoarthropathy, associated with non-small cell lung carcinoma.