Effects of Intravenous and Intracerebroventricular Theophylline on Hypoxic Ventilatory Depression in Anesthetized Cats

• Published in: Medical principles and practice Vol. 13; no. 5; pp. 277 - 281
• Main Authors: Yelmen, N.K., Turgut, G., Şahin, G., Oruç, T.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2004
• Subjects: Anesthesia, General; Animals; Blood Pressure - drug effects; Bronchodilator Agents - administration & dosage; Cats; Hypoxia, Brain - etiology; Hypoxia, Brain - physiopathology; Injections, Intravenous; Injections, Intraventricular; Original Paper; Pulmonary Ventilation - drug effects; Purinergic P1 Receptor Antagonists; Respiratory Insufficiency - complications; Respiratory Insufficiency - physiopathology; Theophylline - administration & dosage; Tidal Volume - drug effects; Hypoxic depression of ventilation; Theophylline; Moderate hypoxia

Objective: The present study was undertaken to investigate the ventilatory response due to sustained isocapnic moderate hypoxia and the possible role of adenosine in hypoxic depression in anesthetized cats. Materials and Methods: Cats anesthetized with pentothal sodium (30 mg kg –1 i.p.) were divide...