Circulating ICAM-1, VCAM-1, E-Selectin, P-Selectin, and TNFαRII in Patients with Coronary Artery Disease

• Published in: Immunological investigations Vol. 32; no. 4; pp. 245 - 257
• Main Authors: Hajilooi, M., Sanati, A., Ahmadieh, A., Ghofraniha, A., Massoud, A.
• Format: Journal Article
• Language: English
• Published: Informa UK Ltd 2003; Taylor & Francis
• Subjects: Adhesion molecules; Atherosclerosis; Coronary artery disease; Coronary heart disease; Tumor necrosis factor receptor 2
• ISSN: 0882-0139; 1532-4311
• DOI: 10.1081/IMM-120025104

Objective: To evaluate the relationship between the serum concentration of TNFαRII and some adhesion molecules (including ICAM-1, VCAM-1, P-selectin and E-selectin) and coronary artery stenosis. Design and setting: Observational (cross-sectional) study in a university heart hospital in Tehran, Iran. Patients: 81 patients with angiographically proven coronary artery disease were compared with 75 individuals who had undergone coronary angiography with no significant evidence of stenosis (control subjects). Methods: Soluble adhesion molecules and TNFαRII were determined by enzyme-linked immunosorbent assay technique. sICAM-1 and sP-selectin values were significantly higher in patients with coronary artery disease than in control subjects (146 ± 38 vs. 132 ± 48 p < 0.04 and 275 ± 107 vs. 241 ± 104 ng ml p < 0.04 respectively). Multiple logistic regression analysis showed sICAM-1 as an independent discriminating risk factor for coronary artery disease (p < 0.03). Prediction models that incorporated sICAM-1 in addition to other established coronary risk factors were significantly better at predicting risk than the models based on the other risk factors alone. Multiple regression analysis indicated that sP-selectin levels were greater in patients with single-vessel disease than in the respective normal (p < 0.01). Conclusions: Our findings suggest that sICAM-1 has an association with stable coronary artery disease and the evaluation of this marker may improve the coronary risk assessment in Iranian patients.