Transcriptomic diversity of cell types across the adult human brain

• Published in: Science (American Association for the Advancement of Science) Vol. 382; no. 6667; p. eadd7046
• Main Authors: Siletti, Kimberly, Hodge, Rebecca, Mossi Albiach, Alejandro, Lee, Ka Wai, Ding, Song-Lin, Hu, Lijuan, Lönnerberg, Peter, Bakken, Trygve, Casper, Tamara, Clark, Michael, Dee, Nick, Gloe, Jessica, Hirschstein, Daniel, Shapovalova, Nadiya V., Keene, C. Dirk, Nyhus, Julie, Tung, Herman, Yanny, Anna Marie, Arenas, Ernest, Lein, Ed S., Linnarsson, Sten
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 13.10.2023
• Subjects: Adult; Astrocytes; Brain; Brain - cytology; Brain - metabolism; Brain stem; Cerebellum; Cerebral cortex; Clusters; Cognition; Cytology; Dopamine receptors; Electrophysiology; Forebrain; Gene Expression Profiling; Gene sequencing; Glial cells; Glial stem cells; Heterogeneity; Hindbrain; Hippocampus; Humans; Hypothalamus; Interneurons; Medulla oblongata; Mesencephalon; Neural networks; Neural stem cells; Neurodegenerative diseases; Neuronal-glial interactions; Neurons; Neurons - metabolism; Neuropeptides; Nuclei (cytology); Oligodendrocytes; Origins; Prosencephalon; Single-Cell Gene Expression Analysis; Telencephalon; Thalamus; Transcriptome

The human brain directs complex behaviors, ranging from fine motor skills to abstract intelligence, but the diversity of cell types that support these skills has not been fully described. In this work, we used single-nucleus RNA sequencing to systematically survey cells across the entire adult human...