Ultra-sensitive pH responsive hydrogels with injectable and self-healing performance for controlled drug delivery

• Published in: International journal of pharmaceutics: X Vol. 9; p. 100334
• Main Authors: Yu, Yang, Zhao, Yili, Zou, Yujiao, Lu, Chanyi, Li, Ni, Shi, Zhiyuan, Li, Xin, Lai, Xixi
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2025; Elsevier
• Subjects: Hydrogel; Injectable; Schiff-base; Self-healing; Ultra pH-sensitive drug release; Injectable; Schiff-base; Self-healing; Hydrogel; Ultra pH-sensitive drug release

Ultra-sensitive pH-responsive drug delivery system designed to operate within the slightly acidic microenvironment of tumors are highly desired for hydrogel applications in cancer therapy. In this study, 4-Formylbenzoic acid modified polyvinyl alcohol (PVA-FBA, PF) was synthesized and utilized as a...