The deregulated promoter methylation of the Polo-like kinases as a potential biomarker in hematological malignancies

• Published in: Leukemia & lymphoma Vol. 56; no. 7; pp. 2123 - 2133
• Main Authors: Ward, Alejandra, Sivakumar, Gayathri, Kanjeekal, Sindu, Hamm, Caroline, Labute, Brayden C., Shum, David, Hudson, John W.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.07.2015
• Subjects: Biomarkers, Tumor - genetics; cancer; cell cycle; Cell Cycle Proteins - genetics; DNA Methylation; Epigenesis, Genetic; epigenetics; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hematologic Neoplasms - diagnosis; Hematologic Neoplasms - genetics; hematology; Humans; methylation; Polo-Like Kinase 1; Polo-like kinases; Prognosis; Promoter Regions, Genetic - genetics; Protein Serine-Threonine Kinases - genetics; Proto-Oncogene Proteins - genetics; Real-Time Polymerase Chain Reaction; Tumor Cells, Cultured; Tumor Suppressor Proteins; Polo-like kinases; hematology; cancer; cell cycle; methylation; epigenetics

Deregulation of Polo-like kinase (PLK) transcription via promoter methylation results in perturbations at the protein level, which has been associated with oncogenesis. Our objective was to further characterize the methylation profile for PLK1-4 in bone marrow aspirates displaying blood neoplasms as...