Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 341; no. 2; pp. 396 - 409
• Main Authors: Kleiman, Robin J, Chapin, Douglas S, Christoffersen, Curt, Freeman, Jody, Fonseca, Kari R, Geoghegan, Kieran F, Grimwood, Sarah, Guanowsky, Victor, Hajós, Mihály, Harms, John F, Helal, Christopher J, Hoffmann, William E, Kocan, Geralyn P, Majchrzak, Mark J, McGinnis, Dina, McLean, Stafford, Menniti, Frank S, Nelson, Fredrick, Roof, Robin, Schmidt, Anne W, Seymour, Patricia A, Stephenson, Diane T, Tingley, Francis David, Vanase-Frawley, Michelle, Verhoest, Patrick R, Schmidt, Christopher J
• Format: Journal Article
• Language: English
• Published: United States 01.05.2012
• Subjects: 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors; 3',5'-Cyclic-AMP Phosphodiesterases - genetics; 3',5'-Cyclic-AMP Phosphodiesterases - metabolism; 3',5'-Cyclic-GMP Phosphodiesterases - metabolism; Animals; Avoidance Learning - drug effects; Brain - drug effects; Brain - metabolism; Cholinergic Agents - pharmacology; Cyclic GMP - metabolism; Female; Humans; Macaca fascicularis; Male; Memory - drug effects; Mice; Mice, Inbred C57BL; Motor Activity - drug effects; Neurons - drug effects; Neurons - metabolism; Neurotransmitter Agents - pharmacology; Phosphodiesterase Inhibitors - pharmacology; Rats; Rats, Long-Evans; Rats, Wistar; Sensory Gating - drug effects; Stereotyped Behavior - drug effects; Synaptic Transmission - drug effects

Cyclic nucleotides are critical regulators of synaptic plasticity and participate in requisite signaling cascades implicated across multiple neurotransmitter systems. Phosphodiesterase 9A (PDE9A) is a high-affinity, cGMP-specific enzyme widely expressed in the rodent central nervous system. In the c...