Chemical analysis using miniaturized and Portable 3D printed systems: Where are we now?
•Capillary and nano LC have emerged as exemplary techniques in GAC field.•Overview of the challenges and advancements achieved in the miniaturization.•Advancements for micro-columns, detectors, lab-on-chip, 3D printing technologies. With the growing emphasis on green chemistry (GC) and green analyti...
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| Published in | Journal of Chromatography Open Vol. 8; p. 100241 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.11.2025
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | •Capillary and nano LC have emerged as exemplary techniques in GAC field.•Overview of the challenges and advancements achieved in the miniaturization.•Advancements for micro-columns, detectors, lab-on-chip, 3D printing technologies.
With the growing emphasis on green chemistry (GC) and green analytical chemistry (GAC), significant efforts have been directed toward minimizing sample size and simplifying sample preparation procedures. Concurrently, ongoing research has enabled the miniaturization of instrumental configurations used for quantitative analysis, aligning with the principles of sustainability.
One major challenge lies in the inherent complexity of liquid chromatography systems, which comprise multiple interconnected components. Each component has been subject to miniaturization, with careful attention to preserving analytical sensitivity, selectivity, and accuracy when applied to real samples. Interest in miniaturized systems is further fueled by the theoretical principle that reducing flow rates enhances the surface-to-volume ratio, thereby improving detection sensitivity.
Building on this theoretical foundation—particularly the goals of portability, efficient sampling, and on site analysis—innovative approaches such as microfluidics and 3D printing have been employed to develop compact fluidic systems. These technologies not only broaden the scope of liquid chromatography but also open new frontiers, such as drug testing on engineered tissues, and the development of new devices suitable for space missions.
This review aims to present a comprehensive overview of the challenges encountered and the advancements achieved in the miniaturization of instrumental setups and portable systems, encompassing both pre- and post-analytical stages. Furthermore, a discussion on 3D technologies available for LC-chip and miniaturized systems was also presented.
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| AbstractList | With the growing emphasis on green chemistry (GC) and green analytical chemistry (GAC), significant efforts have been directed toward minimizing sample size and simplifying sample preparation procedures. Concurrently, ongoing research has enabled the miniaturization of instrumental configurations used for quantitative analysis, aligning with the principles of sustainability.One major challenge lies in the inherent complexity of liquid chromatography systems, which comprise multiple interconnected components. Each component has been subject to miniaturization, with careful attention to preserving analytical sensitivity, selectivity, and accuracy when applied to real samples. Interest in miniaturized systems is further fueled by the theoretical principle that reducing flow rates enhances the surface-to-volume ratio, thereby improving detection sensitivity.Building on this theoretical foundation—particularly the goals of portability, efficient sampling, and on site analysis—innovative approaches such as microfluidics and 3D printing have been employed to develop compact fluidic systems. These technologies not only broaden the scope of liquid chromatography but also open new frontiers, such as drug testing on engineered tissues, and the development of new devices suitable for space missions.This review aims to present a comprehensive overview of the challenges encountered and the advancements achieved in the miniaturization of instrumental setups and portable systems, encompassing both pre- and post-analytical stages. Furthermore, a discussion on 3D technologies available for LC-chip and miniaturized systems was also presented. •Capillary and nano LC have emerged as exemplary techniques in GAC field.•Overview of the challenges and advancements achieved in the miniaturization.•Advancements for micro-columns, detectors, lab-on-chip, 3D printing technologies. With the growing emphasis on green chemistry (GC) and green analytical chemistry (GAC), significant efforts have been directed toward minimizing sample size and simplifying sample preparation procedures. Concurrently, ongoing research has enabled the miniaturization of instrumental configurations used for quantitative analysis, aligning with the principles of sustainability. One major challenge lies in the inherent complexity of liquid chromatography systems, which comprise multiple interconnected components. Each component has been subject to miniaturization, with careful attention to preserving analytical sensitivity, selectivity, and accuracy when applied to real samples. Interest in miniaturized systems is further fueled by the theoretical principle that reducing flow rates enhances the surface-to-volume ratio, thereby improving detection sensitivity. Building on this theoretical foundation—particularly the goals of portability, efficient sampling, and on site analysis—innovative approaches such as microfluidics and 3D printing have been employed to develop compact fluidic systems. These technologies not only broaden the scope of liquid chromatography but also open new frontiers, such as drug testing on engineered tissues, and the development of new devices suitable for space missions. This review aims to present a comprehensive overview of the challenges encountered and the advancements achieved in the miniaturization of instrumental setups and portable systems, encompassing both pre- and post-analytical stages. Furthermore, a discussion on 3D technologies available for LC-chip and miniaturized systems was also presented. [Display omitted] |
| ArticleNumber | 100241 |
| Author | Abollino, Ornella Giacomino, Agnese Perrucci, Miryam Locatelli, Marcello Ricci, Erika Maria Ulusoy, Halil I. Mansour, Fotouh R. Kabir, Abuzar Ali, Imran Inaudi, Paolo Ulusoy, Songül |
| Author_xml | – sequence: 1 givenname: Miryam orcidid: 0009-0006-3484-510X surname: Perrucci fullname: Perrucci, Miryam email: mperrucci@unite.it organization: University of Teramo, Department of Biosciences and Agro-Food and Environmental Technologies, Teramo 64100, Italy – sequence: 2 givenname: Imran surname: Ali fullname: Ali, Imran email: drimran.chiral@gmail.com organization: Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India – sequence: 3 givenname: Fotouh R. surname: Mansour fullname: Mansour, Fotouh R. email: fotouhrashed@pharm.tanta.edu.eg organization: The medical campus of Tanta University, Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Elgeish Street, Tanta, Egypt – sequence: 4 givenname: Halil I. surname: Ulusoy fullname: Ulusoy, Halil I. email: hiulusoy@yahoo.com organization: Department of Analytical Chemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas 58140, Turkey – sequence: 5 givenname: Songül surname: Ulusoy fullname: Ulusoy, Songül email: sonulusoy@yahoo.com organization: Department of Pharmacy, Vocational School of Health Service, Sivas Cumhuriyet University, Sivas 58140, Turkey – sequence: 6 givenname: Abuzar surname: Kabir fullname: Kabir, Abuzar email: akabir@fiu.edu organization: Department of Chemistry and Biochemistry, International Forensic Research Institute, Florida International Univeristy, Miami, FL 33199, USA – sequence: 7 givenname: Ornella surname: Abollino fullname: Abollino, Ornella email: ornella.abollino@unito.it organization: Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy – sequence: 8 givenname: Agnese surname: Giacomino fullname: Giacomino, Agnese email: agnese.giacomino@unito.it organization: Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy – sequence: 9 givenname: Paolo surname: Inaudi fullname: Inaudi, Paolo email: paolo.inaudi@unito.it organization: Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy – sequence: 10 givenname: Marcello orcidid: 0000-0002-0840-825X surname: Locatelli fullname: Locatelli, Marcello email: marcello.locatelli@unich.it organization: Analytical and Bioanalytical Chemistry Laboratory - Department of Science - University “G. d’Annunzio” of Chieti-Pescara, Chieti 66100, Italy – sequence: 11 givenname: Erika Maria surname: Ricci fullname: Ricci, Erika Maria email: erikamaria.ricci@phd.unich.it organization: Analytical and Bioanalytical Chemistry Laboratory - Department of Pharmacy - University “G. d’Annunzio” of Chieti-Pescara, Chieti 66100, Italy |
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| Cites_doi | 10.1021/ac403397r 10.1016/j.aca.2016.01.012 10.1016/j.aca.2020.11.040 10.1021/ac802178u 10.1021/ac4041857 10.1016/j.chroma.2014.10.008 10.1016/j.trac.2023.116951 10.1007/s13361-017-1607-1 10.1007/s42242-021-00165-0 10.1039/D1RA03482K 10.1016/B978-0-12-802139-2.00001-9 10.1002/jssc.202300283 10.3389/fbioe.2024.1355768 10.1021/acs.jproteome.1c00836 10.1007/978-1-4939-2353-3_14 10.1021/acs.analchem.7b04329 10.1002/elps.202300152 10.1021/ac502785j 10.3389/fnano.2021.609355 10.1016/j.talanta.2015.12.018 10.1366/13-07228 10.1038/s41526-025-00476-x 10.1039/C5LC00685F 10.1016/j.snb.2016.05.122 10.1016/j.aca.2019.12.064 10.1146/annurev-anchem-091522-122334 10.1016/j.plaphy.2013.05.019 10.1039/C6LC00542J 10.1007/s00604-024-06726-1 10.1016/j.trac.2022.116892 10.3390/separations8010003 10.1016/j.mne.2019.02.006 10.1021/acs.analchem.7b02490 10.1039/C4AN01476F 10.1016/j.snb.2014.12.098 10.1038/srep32504 10.1002/elps.202300056 10.1016/j.chroma.2016.10.004 10.1515/pac-2020-0206 10.1016/j.aca.2014.12.038 10.1039/C4AY01534G 10.1007/s13361-016-1374-4 10.1146/annurev-anchem-091619-102649 10.1016/j.chroma.2015.06.005 10.1016/j.chroma.2011.07.014 10.1016/j.aca.2014.06.037 10.1080/10408347.2021.1938968 10.1016/j.chroma.2014.01.043 10.1007/s42242-024-00285-3 10.1016/j.bios.2023.115110 10.1016/j.bios.2011.11.021 10.1016/j.jcoa.2024.100180 10.3390/mi14050986 10.1016/j.chroma.2022.462925 10.1016/j.compag.2013.01.004 10.1016/j.jece.2021.105966 10.1021/acssensors.8b01085 10.1016/j.matt.2020.08.034 10.1021/ac303317c 10.1002/bmc.5317 10.1063/1.4905840 10.1016/j.bios.2013.03.051 10.3389/frans.2024.1505510 10.1088/1402-4896/adbc2e 10.3390/coatings11040390 10.1038/s41598-022-16574-9 10.1016/j.chroma.2015.01.002 10.1063/1.4948507 10.1016/j.pmatsci.2022.101020 10.1016/j.talanta.2014.03.047 10.1016/j.trac.2013.01.006 10.1016/j.talanta.2017.02.014 10.1016/j.aca.2024.342429 10.1016/j.copbio.2014.08.009 10.1016/j.talanta.2016.12.056 10.1016/j.chroma.2015.07.090 10.1021/acs.analchem.5b01943 10.1016/j.trac.2019.115735 10.1039/C5AN00462D 10.1021/acs.analchem.7b00195 10.1016/j.envres.2015.05.017 10.1146/annurev-anchem-091120-093659 10.1021/ac403766c 10.1039/c3cs60263j 10.1021/ac504059c 10.1016/j.apgeochem.2016.07.003 10.1007/s13361-014-1026-5 10.1016/j.jpba.2022.114914 10.1007/s10337-018-3671-5 10.1016/j.aca.2017.02.020 10.1080/10826076.2017.1373672 10.1021/ac504275m 10.1002/jssc.202400170 10.1021/acs.analchem.0c01436 10.1016/j.jcoa.2024.100191 10.1159/000168317 10.1149/1945-7111/ad9b53 10.1016/j.jcoa.2022.100066 10.1021/cr300337x 10.1002/bit.28764 10.1016/j.trac.2021.116383 10.3390/bios13010136 10.1021/acs.analchem.5b03070 |
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| Keywords | Lab-on-a-chip Miniaturization 3D printed system Green analytical chemistry and green sample preparation Portable instrumentation |
| Language | English |
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| References | Fedorenko, Bartkevics (bib0004) 2023; 53 Fang, Ma, Fei, Habibi (bib0110) 2025; 100 Yang, Lv, Zhang, Cui (bib0115) 2022; 22 Chen, Chen, Zhou, Kline-Schoder, Sorensen, Cooks, Ouyang (bib0070) 2015; 26 Estlack, Kim (bib0118) 2022; 12 Yuan, Oleschuk (bib0013) 2018; 90 Sánchez, De la Haba, Pérez-Marín (bib0051) 2013; 92 S. Sandron, B. Heery, V. Gupta, D.A. Collins, E.P. Nesterenko, P.N. Nesterenko, M. Talebi, S. Beirne, F. Thompson, G.C. Wallace, D. Brabazon, F. Regan, B. Paull. Functionalised material for 3D printing: microfluidic and microanalytical devicesAnalyst (Cambridge, U. K.) 139 (2014) 6343−6347. Wu, Tian, Li, Andrews, Hawkins, Austin (bib0072) 2017; 28 Bui, Hauser (bib0065) 2015; 1421 . Hinshaw (bib0046) 2015; 33 Plumb, Isaac, Rainville, Hill, Gethings, Johnson, Lauterbach, Wilson (bib0025) 2021; 21 Duarte, Figueredo, Chagas, Cortón, Coltro (bib0101) 2024; 1299 Calabria, Trozzi, Lazzarini, Pace, Zangheri, Iannascoli, Davis, Matadha, De Albuquerque, Pirrotta, Del Bianco, Impresario, Popova, Lovecchio, de Cesare, Caputo, Brucato, Nascetti, Guardigli, Mirasoli (bib0119) 2023; 226 Snyder, Pulliam, Ouyang, Cooks (bib0047) 2016; 88 Shan, Jones (bib0029) 2022; 36 Hengsteler, Kanes, Khasanova, Momotenko (bib0087) 2023; 16 Medina, Lanças (bib0007) 2024; 6 Aydogan, Beltekin, Aslan, Yilmaz, Gokturk, Denizli, El-Rassi (bib0011) 2022; 2 Sikanen, Franssila, Kauppila, Kostiainen, Kotiaho, Ketola (bib0042) 2010; 29 Pluangklang, Wydallis, Cate, Nacapricha, Henry (bib0060) 2014; 6 Malinick, Ebel, Stuart, Valiulis, Hanson, Cheng (bib0086) 2024; 4 Weaver, Lynch, Zhu, Chen, Lu, Pu, Liu (bib0053) 2017; 165 Weindorf, Bakr, Zhu (bib0063) 2014; 128 Sharma, Tolley, Farnsworth, Lee (bib0069) 2015; 87 de los Santos-Ramirez, Boyas-Chavez, Cerrillos-Ordoñez, Mata-Gomez, Gallo-Villanueva, Perez-Gonzalez (bib0041) 2024; 45 Spilstead, Learey, Doeven, Barbante, Mohr, Barnett, Terry, Hall, Francis (bib0094) 2014; 126 Schaefermeier, Szymanski, Weiss, Fu, Lueth, Schmitz, Meiser, Reichart, Sodian (bib0109) 2008; 42 Mejia-Carmona, da Silva Burato, Borsatto, de Toffoli, Lanças (bib0043) 2020; 122 Rogers, Qaderi, Woolley, Nordin (bib0093) 2015; 9 Cecil, Zhang, Guijt, Henderson, Nesterenko, Paull, Breadmore, Macka (bib0067) 2017; 965 Mariet, Vansteene, Losno, Pellé, Jasmin, Bruchet, Hellé (bib0005) 2019; 3 Srinivasan, Raajasubramanian, Ashokkumar, Vinothkumar, Paramaguru, Selvaraj, Kanagalakshimi, Narendra, Krishnan, Sundaram, Murali (bib0014) 2024; 121 Nesterenko (bib0100) 2020; 92 Su, Hsia, Sun (bib0092) 2014; 838 Cruz, de Souza, Lanças, Queiroz (bib0026) 2022; 1668 Lambert, Valiulis, Cheng (bib0031) 2018; 3 Xiong, Tan, Fang, Wang, Wang, Wu, Chen, Duan, LEDbased (bib0056) 2017; 167 Young, Evans, Hodges, Bleacher, Graff (bib0064) 2016; 72 Parida, Saidulu, Majumder, Srivastava, Gupta, Gupta (bib0083) 2021; 9 Graja, Gumieniak, Dzimira, Janisz, Krakos (bib0120) 2024; 191 Gilar, McDonald, Gritti (bib0024) 2016; 1470 Korany, Mahgoub, Haggag, Ragab, Elmallah (bib0019) 2017; 40 Salentijn, Permentier, Verpoorte (bib0095) 2014; 86 Kašička (bib0040) 2024; 45 Santoni, Gugliandolo, Sponchioni, Moscatelli, Colosimo (bib0105) 2022; 5 Thurmann, Mauritz, Heck, Belder (bib0032) 2014; 1370 Agrawal, Keçili, Ghorbani-Bidkorbeh, Hussain (bib0084) 2021; 143 Huang, Shao, Li (bib0106) 2023; 131 Yang, Yu, Rudi Strickler, Chang, Gunasekaran (bib0059) 2013; 47 Mehta, Lee, Cha, Tung, Linderman, Takayama (bib0108) 2009; 81 Abdalla, Patel (bib0099) 2021; 14 Svec, Lv (bib0035) 2015; 87 Bao, Wang, Thushara, Liyanage, Gunawardena, Yang, Zhao (bib0002) 2020; 8 Dolan (bib0045) 2006; 25 Smith, Jjunju, Taylor, Young, Maher (bib0076) 2016 Aydogan, Rigano, Krcmova, Chung, Macka, Mondello (bib0010) 2020; 92 Chen, Lin, Tian, Shi, Cooks, Ouyang (bib0075) 2015; 87 Locatelli, Kabir, Perrucci, Ulusoy, Ulusoy, Ali (bib0001) 2023; 6 Yola, Eren, Atar (bib0061) 2015; 210 Nielsen, Beauchamp, Nordin, Woolley (bib0111) 2020; 13 Raucci, Buonciro, Mancini, Gioia, Frugis, Cinti (bib0098) 2024; 171 Griffin, Pappas (bib0112) 2023; 158 Thomas, Zhang, Nguyen, Ta (bib0018) 2023; 13 Bosco (bib0062) 2013; 45 Bui, Hauser (bib0066) 2016; 235 Zhai, Zhang, Xu, Zheng, Yuan, Xu (bib0081) 2017; 89 Knob, Sahore, Sonker, Woolley (bib0034) 2016; 10 Ding, Zhang, Wang, Tang, Dong, Zhang, Ho, Zhang (bib0068) 2016; 16 Oedit, Vulto, Ramautar, Lindenburg, Hankemeier (bib0016) 2015; 31 Gałuszka, Migaszewski, Namieśnik (bib0055) 2015; 140 Keough, McLeod, Salomons, Hillen, Pei, Gibson, She (bib0085) 2021; 11 Duarte, Figueredo, Chagas, Cortón, Coltro (bib0116) 2024; 1299 Galan, Zhao, Wang, Dai, Huck, Ma (bib0017) 2020; 3 Li, Chen, Ren, Hendricks, Cooks, Ouyang (bib0074) 2014; 86 Salentijn, Oleschuk, Verpoorte (bib0096) 2017; 89 Gupta, Talebi, Deverell, Sandron, Nesterenko, Heery, Thompson, Beirne, Wallace, Paull (bib0090) 2019; 910 Tripathi, Mandal, Bauri, Maiti (bib0104) 2023; 4 Mitrogiannopoulou, Tselepi, Ellinas (bib0020) 2023; 14 Salmean, Dimartino (bib0030) 2019; 82 Ho, Ng, Li, Yoon (bib0037) 2015; 15 Gilar, McDonald, Roman, Johnson, Murphy, Jorgenson (bib0023) 2015; 1381 Ng, Shkolnikov (bib0107) 2024; 7 Fang, Li, Fang, Pan, Fang (bib0052) 2016; 150 AlMashrea, Almehdi, Damiati (bib0113) 2024; 12 Vandenabeele, Edwards, Jehlicka (bib0048) 2014; 43 Calvo-López, Ymbern, Puyol, Casalta, Alonso-Chamarro (bib0117) 2015; 874 Padilla, Hovell, Mares, Reumers, Clements, Rextroat, Gamble, Lumpp, Joddar (bib0121) 2025; 11 Das, Wahi, Kothari, Raskar (bib0054) 2016; 6 Lebanov, Mikhail, Paull (bib0057) 2024; 6 Ma, Li, Wang, Ma, Hu, Li, Wu (bib0006) 2023; 160 Hemida, Ghiasvand, Macka, Gupta, Haddad, Paull (bib0008) 2023; 46 Nge, Rogers, Woolley (bib0022) 2013; 113 last access July, 02, 2025. Tümer, Erbil (bib0102) 2021; 11 M.K. Thimmaraju, R. Trivedi, G. Hemalatha, B. Thirupathy, A.M. Billah. Microfluidic revolution and its impact on pharmaceutical materials: a review. Mater. Today Proc., 1–5. dos Santos, Lopo, Páscoa, Lopes (bib0049) 2013; 67 Prabhakar, Sen, Dwivedi, Khan, Solanki, Srivastava, Dhand (bib0114) 2021; 3 Gross, Erkal, Lockwood, Chen, Spence (bib0036) 2014; 86 Eggleston-Rangel (bib0038) 2021; 17 Desmet, Eeltink (bib0027) 2013; 85 Ladner, Crétier, Faure (bib0033) 2015; 1274 Fee, Nawada, Dimartino (bib0091) 2019; 1333 Sun, Zeng, Liu, Zhou, Chen, Chen, Huang, Gao, Wang, Zhang, Wang, Eeltink, Zhang (bib0044) 2025; 64 Ecarnot, Bączyk, Tessarotto, Chervin (bib0050) 2013; 70 Gritti, Guiochon (bib0021) 2012; 1228 Maciel, de Toffoli, Sobieski, Nazário, Lancas (bib0028) 2020; 1103 Liu, Otsuka, Kawai (bib0039) 2024; 47 Agrawal, Yıldız, Hussain, Kailasa, Keçili, Hussain (bib0012) 2022; 219 Internet site Pena-Pereira, Bendicho, Pavlović, Martín-Esteban, Díaz-Álvarez, Pan, Cooper, Yang, Safarik, Pospiskova, Segundo, Psillakis (bib0082) 2021; 1158 Wolf, Etter, Schaer, Siegenthaler, Zenobi (bib0071) 2016; 27 Zhai, Feng, Wei, Wang, Xu (bib0073) 2015; 140 Liang, Li, Zhang, Zhang, Chen, Qi, Yi, Hu (bib0058) 2012; 31 Sestak, Moravcova, Kahle (bib0009) 2015; 1421 Iula, Miglione, Kalligosfyri, Spinelli, Amoresano, Di Natale, Darwish, Cinti (bib0097) 2025 Shallan, Smejkal, Corban, Guijt, Breadmore (bib0088) 2014 Katheng, Prawatvatchara, Chaiamornsup, Sornsuwan, Lekatana, Palasuk (bib0103) 2025; 15 Philippart, Peulon-Agasse, Rizk-Bigourd, Boco-Simon, Bergerot, Rioland, Buch, Szopa, Cardinael (bib0003) 2024; 6 Hinshaw (10.1016/j.jcoa.2025.100241_bib0046) 2015; 33 Padilla (10.1016/j.jcoa.2025.100241_bib0121) 2025; 11 Gupta (10.1016/j.jcoa.2025.100241_bib0090) 2019; 910 Fang (10.1016/j.jcoa.2025.100241_bib0110) 2025; 100 Plumb (10.1016/j.jcoa.2025.100241_bib0025) 2021; 21 Estlack (10.1016/j.jcoa.2025.100241_bib0118) 2022; 12 Snyder (10.1016/j.jcoa.2025.100241_bib0047) 2016; 88 Malinick (10.1016/j.jcoa.2025.100241_bib0086) 2024; 4 Vandenabeele (10.1016/j.jcoa.2025.100241_bib0048) 2014; 43 Fedorenko (10.1016/j.jcoa.2025.100241_bib0004) 2023; 53 Eggleston-Rangel (10.1016/j.jcoa.2025.100241_bib0038) 2021; 17 Chen (10.1016/j.jcoa.2025.100241_bib0075) 2015; 87 Pluangklang (10.1016/j.jcoa.2025.100241_bib0060) 2014; 6 Chen (10.1016/j.jcoa.2025.100241_bib0070) 2015; 26 Young (10.1016/j.jcoa.2025.100241_bib0064) 2016; 72 Gałuszka (10.1016/j.jcoa.2025.100241_bib0055) 2015; 140 Calvo-López (10.1016/j.jcoa.2025.100241_bib0117) 2015; 874 Wolf (10.1016/j.jcoa.2025.100241_bib0071) 2016; 27 Nielsen (10.1016/j.jcoa.2025.100241_bib0111) 2020; 13 Tümer (10.1016/j.jcoa.2025.100241_bib0102) 2021; 11 Yang (10.1016/j.jcoa.2025.100241_bib0115) 2022; 22 Medina (10.1016/j.jcoa.2025.100241_bib0007) 2024; 6 Parida (10.1016/j.jcoa.2025.100241_bib0083) 2021; 9 Thurmann (10.1016/j.jcoa.2025.100241_bib0032) 2014; 1370 Ladner (10.1016/j.jcoa.2025.100241_bib0033) 2015; 1274 10.1016/j.jcoa.2025.100241_bib0015 Gritti (10.1016/j.jcoa.2025.100241_bib0021) 2012; 1228 Salmean (10.1016/j.jcoa.2025.100241_bib0030) 2019; 82 Lambert (10.1016/j.jcoa.2025.100241_bib0031) 2018; 3 Liang (10.1016/j.jcoa.2025.100241_bib0058) 2012; 31 Prabhakar (10.1016/j.jcoa.2025.100241_bib0114) 2021; 3 Sharma (10.1016/j.jcoa.2025.100241_bib0069) 2015; 87 Sestak (10.1016/j.jcoa.2025.100241_bib0009) 2015; 1421 Su (10.1016/j.jcoa.2025.100241_bib0092) 2014; 838 Schaefermeier (10.1016/j.jcoa.2025.100241_bib0109) 2008; 42 Aydogan (10.1016/j.jcoa.2025.100241_bib0010) 2020; 92 Mejia-Carmona (10.1016/j.jcoa.2025.100241_bib0043) 2020; 122 Shallan (10.1016/j.jcoa.2025.100241_bib0088) 2014 Iula (10.1016/j.jcoa.2025.100241_bib0097) 2025 Santoni (10.1016/j.jcoa.2025.100241_bib0105) 2022; 5 Huang (10.1016/j.jcoa.2025.100241_bib0106) 2023; 131 Thomas (10.1016/j.jcoa.2025.100241_bib0018) 2023; 13 Yang (10.1016/j.jcoa.2025.100241_bib0059) 2013; 47 Rogers (10.1016/j.jcoa.2025.100241_bib0093) 2015; 9 Maciel (10.1016/j.jcoa.2025.100241_bib0028) 2020; 1103 Tripathi (10.1016/j.jcoa.2025.100241_bib0104) 2023; 4 Keough (10.1016/j.jcoa.2025.100241_bib0085) 2021; 11 Zhai (10.1016/j.jcoa.2025.100241_bib0073) 2015; 140 Shan (10.1016/j.jcoa.2025.100241_bib0029) 2022; 36 Salentijn (10.1016/j.jcoa.2025.100241_bib0096) 2017; 89 Agrawal (10.1016/j.jcoa.2025.100241_bib0012) 2022; 219 Smith (10.1016/j.jcoa.2025.100241_bib0076) 2016 Lebanov (10.1016/j.jcoa.2025.100241_bib0057) 2024; 6 Pena-Pereira (10.1016/j.jcoa.2025.100241_bib0082) 2021; 1158 Raucci (10.1016/j.jcoa.2025.100241_bib0098) 2024; 171 Galan (10.1016/j.jcoa.2025.100241_bib0017) 2020; 3 Hemida (10.1016/j.jcoa.2025.100241_bib0008) 2023; 46 Bui (10.1016/j.jcoa.2025.100241_bib0065) 2015; 1421 Korany (10.1016/j.jcoa.2025.100241_bib0019) 2017; 40 Knob (10.1016/j.jcoa.2025.100241_bib0034) 2016; 10 Calabria (10.1016/j.jcoa.2025.100241_bib0119) 2023; 226 Ho (10.1016/j.jcoa.2025.100241_bib0037) 2015; 15 Gross (10.1016/j.jcoa.2025.100241_bib0036) 2014; 86 Sikanen (10.1016/j.jcoa.2025.100241_bib0042) 2010; 29 Srinivasan (10.1016/j.jcoa.2025.100241_bib0014) 2024; 121 Yuan (10.1016/j.jcoa.2025.100241_bib0013) 2018; 90 Katheng (10.1016/j.jcoa.2025.100241_bib0103) 2025; 15 Zhai (10.1016/j.jcoa.2025.100241_bib0081) 2017; 89 Xiong (10.1016/j.jcoa.2025.100241_bib0056) 2017; 167 Hengsteler (10.1016/j.jcoa.2025.100241_bib0087) 2023; 16 Locatelli (10.1016/j.jcoa.2025.100241_bib0001) 2023; 6 Sánchez (10.1016/j.jcoa.2025.100241_bib0051) 2013; 92 Yola (10.1016/j.jcoa.2025.100241_bib0061) 2015; 210 Fee (10.1016/j.jcoa.2025.100241_bib0091) 2019; 1333 Weindorf (10.1016/j.jcoa.2025.100241_bib0063) 2014; 128 Nge (10.1016/j.jcoa.2025.100241_bib0022) 2013; 113 Mehta (10.1016/j.jcoa.2025.100241_bib0108) 2009; 81 Weaver (10.1016/j.jcoa.2025.100241_bib0053) 2017; 165 Sun (10.1016/j.jcoa.2025.100241_bib0044) 2025; 64 Graja (10.1016/j.jcoa.2025.100241_bib0120) 2024; 191 Das (10.1016/j.jcoa.2025.100241_bib0054) 2016; 6 Duarte (10.1016/j.jcoa.2025.100241_bib0101) 2024; 1299 Desmet (10.1016/j.jcoa.2025.100241_bib0027) 2013; 85 Philippart (10.1016/j.jcoa.2025.100241_bib0003) 2024; 6 Abdalla (10.1016/j.jcoa.2025.100241_bib0099) 2021; 14 Griffin (10.1016/j.jcoa.2025.100241_bib0112) 2023; 158 Mariet (10.1016/j.jcoa.2025.100241_bib0005) 2019; 3 Ecarnot (10.1016/j.jcoa.2025.100241_bib0050) 2013; 70 AlMashrea (10.1016/j.jcoa.2025.100241_bib0113) 2024; 12 Gilar (10.1016/j.jcoa.2025.100241_bib0023) 2015; 1381 Spilstead (10.1016/j.jcoa.2025.100241_bib0094) 2014; 126 Kašička (10.1016/j.jcoa.2025.100241_bib0040) 2024; 45 Fang (10.1016/j.jcoa.2025.100241_bib0052) 2016; 150 Bosco (10.1016/j.jcoa.2025.100241_bib0062) 2013; 45 Liu (10.1016/j.jcoa.2025.100241_bib0039) 2024; 47 Wu (10.1016/j.jcoa.2025.100241_bib0072) 2017; 28 10.1016/j.jcoa.2025.100241_bib0089 Ng (10.1016/j.jcoa.2025.100241_bib0107) 2024; 7 Svec (10.1016/j.jcoa.2025.100241_bib0035) 2015; 87 Salentijn (10.1016/j.jcoa.2025.100241_bib0095) 2014; 86 Gilar (10.1016/j.jcoa.2025.100241_bib0024) 2016; 1470 Li (10.1016/j.jcoa.2025.100241_bib0074) 2014; 86 Ding (10.1016/j.jcoa.2025.100241_bib0068) 2016; 16 Mitrogiannopoulou (10.1016/j.jcoa.2025.100241_bib0020) 2023; 14 Dolan (10.1016/j.jcoa.2025.100241_bib0045) 2006; 25 Duarte (10.1016/j.jcoa.2025.100241_bib0116) 2024; 1299 Aydogan (10.1016/j.jcoa.2025.100241_bib0011) 2022; 2 Bao (10.1016/j.jcoa.2025.100241_bib0002) 2020; 8 Ma (10.1016/j.jcoa.2025.100241_bib0006) 2023; 160 Cruz (10.1016/j.jcoa.2025.100241_bib0026) 2022; 1668 10.1016/j.jcoa.2025.100241_bib0080 Cecil (10.1016/j.jcoa.2025.100241_bib0067) 2017; 965 Agrawal (10.1016/j.jcoa.2025.100241_bib0084) 2021; 143 dos Santos (10.1016/j.jcoa.2025.100241_bib0049) 2013; 67 10.1016/j.jcoa.2025.100241_bib0078 10.1016/j.jcoa.2025.100241_bib0077 Oedit (10.1016/j.jcoa.2025.100241_bib0016) 2015; 31 10.1016/j.jcoa.2025.100241_bib0079 de los Santos-Ramirez (10.1016/j.jcoa.2025.100241_bib0041) 2024; 45 Bui (10.1016/j.jcoa.2025.100241_bib0066) 2016; 235 Nesterenko (10.1016/j.jcoa.2025.100241_bib0100) 2020; 92 |
| References_xml | – volume: 226 start-page: 1 year: 2023 end-page: 10 ident: bib0119 article-title: AstroBio-CubeSat: a lab-in-space for chemiluminescence-based astrobiology experiments publication-title: Biosens. Bioelectron. – volume: 140 start-page: 593 year: 2015 end-page: 603 ident: bib0055 article-title: Moving your laboratories to the field – advantages and limitations of the use of field portable instruments in environmental sample analysis publication-title: Environ. Res. – volume: 64 start-page: 12372 year: 2025 end-page: 12378 ident: bib0044 article-title: Microfluidic precision manufacture of high performance liquid chromatographic microspheres publication-title: Angew. Chem. Int. Ed. – volume: 12 start-page: 1 year: 2024 end-page: 13 ident: bib0113 article-title: Simple microfluidic devices for in situ detection of water contamination: a state-of-art review publication-title: Front. Bioeng. Biotechnol. – volume: 67 start-page: 1215 year: 2013 end-page: 1233 ident: bib0049 article-title: A review on the applications of portable near-infrared spectrometers in the agro-food industry publication-title: Appl. Spectrosc. – volume: 219 start-page: 1 year: 2022 end-page: 9 ident: bib0012 article-title: Greenness of lab-on-a-chip devices for analytical processes: advances & future prospects publication-title: J. Pharm. Biomed. Anal. – volume: 9 start-page: 1 year: 2021 end-page: 20 ident: bib0083 article-title: Emerging contaminants in wastewater: a critical review on occurrence, existing legislations, risk assessment, and sustainable treatment alternatives publication-title: J. Environ. Chem. Eng. – volume: 1333 start-page: 18 year: 2019 end-page: 24 ident: bib0091 article-title: 3D-Printed stationary phases with ordered morphology: state of the art and future development in liquid chromatography publication-title: Chromatographia – volume: 838 start-page: 58 year: 2014 end-page: 63 ident: bib0092 article-title: Three-dimensional printed sample load/inject valves enabling online monitoring of extracellular calcium and zinc ions in living rat brains publication-title: Anal. Chim. Acta. – volume: 1668 start-page: 1 year: 2022 end-page: 16 ident: bib0026 article-title: Current advances and applications of online sample preparation techniques for miniaturized liquid chromatography systems publication-title: J. Chromatogr. A – volume: 92 start-page: 1341 year: 2020 end-page: 1355 ident: bib0100 article-title: 3D printing in analytical chemistry: current state and future publication-title: Pure Appl. Chem. – volume: 45 start-page: 121 year: 2013 end-page: 134 ident: bib0062 article-title: Development and application of portable, hand-held X-ray fluorescence spectrometers publication-title: TrAC Trends Anal. Chem. – volume: 171 year: 2024 ident: bib0098 article-title: On-site electrochemical sensor for carbamazepine monitoring in aquatic environments publication-title: J. Electrochem. Soc. – volume: 45 start-page: 69 year: 2024 end-page: 100 ident: bib0041 article-title: Trends and challenges in microfluidic methods for protein manipulation—a review publication-title: Electrophoresis – volume: 87 start-page: 250 year: 2015 end-page: 273 ident: bib0035 article-title: Advances and recent trends in the field of monolithic columns for chromatography publication-title: Anal. Chem. – volume: 3 start-page: 1 year: 2021 end-page: 16 ident: bib0114 article-title: 3D-Printed microfluidics and potential biomedical applications publication-title: Front. Nanotechnol. – volume: 33 start-page: 850 year: 2015 end-page: 855 ident: bib0046 article-title: What is “dead” volume and why should chromatographers worry about it? publication-title: LCGC North Am. – volume: 14 start-page: 1 year: 2023 end-page: 44 ident: bib0020 article-title: Polymeric and paper-based lab-on-a-chip devices in food safety: a review publication-title: Micromachines – volume: 143 start-page: 1 year: 2021 end-page: 16 ident: bib0084 article-title: Green miniaturized technologies in analytical and bioanalytical chemistry publication-title: TrAC, Trends Anal. Chem. – start-page: 3124 year: 2014 end-page: 3130 ident: bib0088 article-title: Cost-effective three-dimensional printing of visibly transparent microchips within minutes publication-title: Anal. Chem. – volume: 43 start-page: 2628 year: 2014 end-page: 2649 ident: bib0048 article-title: The role of mobile instrumentation in novel applications of Raman spectroscopy: archaeometry, geosciences, and forensics publication-title: Chem. Soc. Rev. – volume: 27 start-page: 1197 year: 2016 end-page: 1202 ident: bib0071 article-title: Direct and sensitive detection of CWA simulants by active capillary plasma ionization coupled to a handheld ion trap mass spectrometer publication-title: J. Am. Soc. Mass Spectrom. – volume: 72 start-page: 77 year: 2016 end-page: 87 ident: bib0064 article-title: A review of the handheld X-ray fluorescence spectrometer as a tool for field geologic investigations on Earth and in planetary surface exploration publication-title: Appl. Geochem. – reference: , last access July, 02, 2025. – volume: 88 start-page: 2 year: 2016 end-page: 29 ident: bib0047 article-title: Miniature and fieldable mass spectrometers: recent advances publication-title: Anal. Chem. – volume: 128 start-page: 1 year: 2014 end-page: 45 ident: bib0063 article-title: Advances in portable x-ray fluorescence (PXRF) for environmental, pedological, and agronomic applications publication-title: Adv. Agron. – volume: 9 start-page: 1 year: 2015 end-page: 9 ident: bib0093 article-title: 3D printed microfluidic devices with integrated valves publication-title: Biomicrofluidics – volume: 26 start-page: 240 year: 2015 end-page: 247 ident: bib0070 article-title: Design of portable mass spectrometers with handheld probes: aspects of the sampling and miniature pumping systems publication-title: J. Am. Soc. Mass Spectrom. – volume: 82 start-page: 443 year: 2019 end-page: 463 ident: bib0030 article-title: 3D-printed stationary phases with ordered morphology: state of the art and future development in liquid chromatography publication-title: Chromatographia – volume: 42 start-page: 49 year: 2008 end-page: 53 ident: bib0109 article-title: Design and fabrication of three-dimensional scaffolds for tissue engineering of human heart valves publication-title: Eur .Surg. Res. – volume: 3 start-page: 1893 year: 2020 end-page: 1922 ident: bib0017 article-title: Intelligent microfluidics: the convergence of machine learning and microfluidics in materials science and biomedicine publication-title: Matter – volume: 122 start-page: 1 year: 2020 end-page: 15 ident: bib0043 article-title: Miniaturization of liquid chromatography coupled to mass spectrometry: 1. Current trends on miniaturized LC columns publication-title: TrAC, Trends Anal. Chem. – volume: 6 start-page: 8180 year: 2014 end-page: 8186 ident: bib0060 article-title: A simple microfluidic electrochemical HPLC detector for quantifying Fenton reactivity from welding fumes publication-title: Anal. Methods. – volume: 1421 start-page: 203 year: 2015 end-page: 208 ident: bib0065 article-title: Absorbance detector for capillary electrophoresis based on light-emitting diodes and photodiodes for the deep-ultraviolet range publication-title: J. Chromatogr. A – volume: 40 start-page: 839 year: 2017 end-page: 852 ident: bib0019 article-title: Green chemistry: analytical and chromatography publication-title: J. Liq. Chromatogr. Relat. Technol. – volume: 89 start-page: 11419 year: 2017 end-page: 11426 ident: bib0096 article-title: 3D-printed paper spray ionization cartridge with integrated desolvation feature and ion optics publication-title: Anal. Chem. – volume: 11 start-page: 1 year: 2025 end-page: 12 ident: bib0121 article-title: Adoption of microfluidic MEA technology for electrophysiology of 3D neuronal networks exposed to suborbital conditions publication-title: npj Microgravity – volume: 89 start-page: 4177 year: 2017 end-page: 4183 ident: bib0081 article-title: Mini mass spectrometer integrated with a miniature ion funnel publication-title: Anal. Chem. – volume: 10 start-page: 1 year: 2016 end-page: 19 ident: bib0034 article-title: Advances in monoliths and related porous materials for microfluidics publication-title: Biomicrofluidics – volume: 70 start-page: 159 year: 2013 end-page: 163 ident: bib0050 article-title: Rapid phenotyping of the tomato fruit model, Micro-Tom, with a portable VIS–NIR spectrometer publication-title: Plant Physiol. Biochem. – volume: 86 start-page: 2909 year: 2014 end-page: 2916 ident: bib0074 article-title: Mini 12, miniature mass spectrometer for clinical and other applications - introduction and characterization publication-title: Anal. Chem. – volume: 46 start-page: 1 year: 2023 end-page: 20 ident: bib0008 article-title: Recent advances in miniaturization of portable liquid chromatography with emphasis on detection publication-title: J. Sep. Sci. – volume: 13 start-page: 45 year: 2020 end-page: 65 ident: bib0111 article-title: 3D printed microfluidics publication-title: Annu. Rev. Anal. Chem. – volume: 1381 start-page: 110 year: 2015 end-page: 117 ident: bib0023 article-title: Repetitive injection method: a tool for investigation of injection zone formation and its compression in microfluidic liquid chromatography publication-title: J. Chromatogr. A – volume: 1103 start-page: 11 year: 2020 end-page: 31 ident: bib0028 article-title: Miniaturized liquid chromatography focusing on analytical columns and mass spectrometry: a review publication-title: Anal. Chim. Acta – volume: 4 start-page: e194 year: 2023 ident: bib0104 article-title: 3D bioprinting and its innovative approach for biomedical applications publication-title: Med. Comm. – start-page: 1 year: 2025 end-page: 10 ident: bib0097 article-title: On-body electrochemical measurement of sweat lactate with the use of paper-based fluidics and 3D-printed flexible wearable biosensor publication-title: Anal. Bioanal. Chem. – volume: 53 start-page: 98 year: 2023 end-page: 122 ident: bib0004 article-title: Recent applications of nano-liquid chromatography in food safety and environmental monitoring: a review publication-title: Crit. Rev. Anal. Chem. – volume: 81 start-page: 3714 year: 2009 end-page: 3722 ident: bib0108 article-title: Hard top soft bottom microfluidic devices for cell culture and chemical analysis publication-title: Anal. Chem. – volume: 874 start-page: 26 year: 2015 end-page: 32 ident: bib0117 article-title: Potentiometric analytical microsystem based on the integration of a gas-diffusion step for on-line ammonium determination in water recycling processes in manned space missions publication-title: Anal. Chim. Acta. – volume: 160 start-page: 1 year: 2023 end-page: 20 ident: bib0006 article-title: Advances in application and innovation of microfluidic platforms for pharmaceutical analysis publication-title: TrAC, Trends Anal. Chem. – volume: 121 start-page: 2585 year: 2024 end-page: 2603 ident: bib0014 article-title: Nanobiosensors based on on-site detection approaches for rapid pesticide sensing in the agricultural arena: a systematic review of the current status and perspectives publication-title: Biotechnol. Bioeng. – volume: 86 start-page: 11657 year: 2014 end-page: 11665 ident: bib0095 article-title: 3D-printed paper spray ionization cartridge with fast wetting and continuous solvent supply features publication-title: Anal. Chem. – volume: 158 year: 2023 ident: bib0112 article-title: 3D printed microfluidics for bioanalysis: a review of recent advancements and applications publication-title: TrAC, Trends Anal. Chem. – volume: 12 start-page: 1 year: 2022 end-page: 10 ident: bib0118 article-title: Microvalve array fabrication using selective PDMS (polydimethylsiloxane) bonding through perfluorooctyl-trichlorosilane passivation for long-term space exploration publication-title: Sci. Rep. – volume: 210 start-page: 149 year: 2015 end-page: 157 ident: bib0061 article-title: A sensitive molecular imprinted electrochemical sensor based on gold nanoparticles decorated graphene oxide: application to selective determination of tyrosine in milk publication-title: Sens. Actuators B: Chem. – volume: 29 start-page: 351 year: 2010 end-page: 391 ident: bib0042 article-title: Microchip technology in mass spectrometry publication-title: Mass Spectrom. Rev. – volume: 3 start-page: 2475 year: 2018 end-page: 2491 ident: bib0031 article-title: Advances in optical sensing and bioanalysis enabled by 3D printing publication-title: ACS Sens. – volume: 16 start-page: 71 year: 2023 end-page: 91 ident: bib0087 article-title: Beginner's guide to micro-and nanoscale electrochemical additive manufacturing publication-title: Annu. Rev. Anal. Chem. – volume: 86 start-page: 3240 year: 2014 end-page: 3253 ident: bib0036 article-title: Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences publication-title: Anal. Chem. – volume: 87 start-page: 8867 year: 2015 end-page: 8873 ident: bib0075 article-title: Real-time sample analysis using a sampling probe and miniature mass spectrometer publication-title: Anal. Chem. – volume: 1470 start-page: 76 year: 2016 end-page: 83 ident: bib0024 article-title: Experimental evaluation of chromatographic performance of capillary and microfluidic columns with linear or curved channels publication-title: J. Chromatogr. A. – volume: 6 start-page: 1 year: 2023 end-page: 15 ident: bib0001 article-title: Green profile tools: current status and future perspectives publication-title: Adv. Sample Prep. – volume: 13 start-page: 136 year: 2023 ident: bib0018 article-title: Microfluidic gut-on-a-chip: fundamentals and challenges publication-title: Biosensors – volume: 85 start-page: 543 year: 2013 end-page: 556 ident: bib0027 article-title: Fundamentals for LC miniaturization publication-title: Anal. Chem. – volume: 8 start-page: 1 year: 2020 end-page: 19 ident: bib0002 article-title: Recent advances in microfluidics-based chromatography—a mini review publication-title: Separations – volume: 113 start-page: 2550 year: 2013 end-page: 2583 ident: bib0022 article-title: Advances in microfluidic materials, functions, integration, and applications publication-title: Chem. Rev. – volume: 36 start-page: 1 year: 2022 end-page: 20 ident: bib0029 article-title: Nano-LC: an updated review publication-title: Biomed. Chromatogr. – volume: 5 start-page: 14 year: 2022 end-page: 42 ident: bib0105 article-title: 3D bioprinting: current status and trends—a guide to the literature and industrial practice publication-title: Bio-Des. Manuf. – volume: 140 start-page: 3406 year: 2015 end-page: 3414 ident: bib0073 article-title: Development of a miniature mass spectrometer with continuous atmospheric pressure interface publication-title: Analyst – volume: 910 start-page: 84 year: 2019 end-page: 94 ident: bib0090 article-title: 3D-Printed stationary phases with ordered morphology: state of the art and future development in liquid chromatography publication-title: Anal. Chim. Acta. – volume: 1421 start-page: 2 year: 2015 end-page: 17 ident: bib0009 article-title: Instrument platforms for nano liquid chromatography publication-title: J. Chromatogr. A – volume: 6 start-page: 1 year: 2024 end-page: 14 ident: bib0007 article-title: What still hinders the routine application of miniaturized liquid chromatography beyond the omics sciences? publication-title: J. Chromatogr. Open – volume: 1228 start-page: 2 year: 2012 end-page: 19 ident: bib0021 article-title: The current revolution in column technology: how it began, where is it going? publication-title: J. Chromatogr. A – volume: 1274 start-page: 161 year: 2015 end-page: 167 ident: bib0033 article-title: Electrochromatography on acrylate-based monolith in cyclic olefin copolymer microchip: an attractive technology publication-title: Microchip Cap. Electrophor. Prot. – reference: Internet site: – volume: 6 start-page: 1 year: 2024 end-page: 12 ident: bib0003 article-title: Microchip gas chromatographic columns dedicated for space exploration: stationary phase coating, setup optimization and evaluation of column performances publication-title: J. Chromatogr. Open – volume: 21 start-page: 691 year: 2021 end-page: 701 ident: bib0025 article-title: High throughput UHPLC-MS-based lipidomics using vacuum jacketed columns publication-title: J. Proteome Res. – volume: 2 start-page: 1 year: 2022 end-page: 13 ident: bib0011 article-title: Nanoscale separation: recent achievements publication-title: J. Chromatogr. Open. – volume: 3 start-page: 7 year: 2019 end-page: 14 ident: bib0005 article-title: Microfluidics devices applied to radionuclides separation in acidic media for the nuclear fuel cycle publication-title: Micro Nano Eng. – reference: M.K. Thimmaraju, R. Trivedi, G. Hemalatha, B. Thirupathy, A.M. Billah. Microfluidic revolution and its impact on pharmaceutical materials: a review. Mater. Today Proc., 1–5. – volume: 165 start-page: 240 year: 2017 end-page: 244 ident: bib0053 article-title: Confocal laserinduced fluorescence detector for narrow capillary system with yoctomole limit of detection publication-title: Talanta – volume: 7 start-page: 771 year: 2024 end-page: 799 ident: bib0107 article-title: Jetting-based bioprinting: process, dispense physics, and applications publication-title: Bio-Des. Manuf. – reference: S. Sandron, B. Heery, V. Gupta, D.A. Collins, E.P. Nesterenko, P.N. Nesterenko, M. Talebi, S. Beirne, F. Thompson, G.C. Wallace, D. Brabazon, F. Regan, B. Paull. Functionalised material for 3D printing: microfluidic and microanalytical devicesAnalyst (Cambridge, U. K.) 139 (2014) 6343−6347. – volume: 17 start-page: 21 year: 2021 end-page: 25 ident: bib0038 article-title: Why use miniaturized columns in liquid chromatography? Benefits and challenges publication-title: Column – volume: 965 start-page: 131 year: 2017 end-page: 136 ident: bib0067 article-title: 3D printed LED based on-capillary detector housing with integrated slit publication-title: Anal. Chim. Acta. – volume: 1158 start-page: 1 year: 2021 end-page: 31 ident: bib0082 article-title: Miniaturized analytical methods for determination of environmental contaminants of emerging concern–a review publication-title: Anal. Chim. Acta – volume: 126 start-page: 110 year: 2014 end-page: 115 ident: bib0094 article-title: 3D-printed and CNC milled flow-cells for chemiluminescence detection publication-title: Talanta – volume: 47 start-page: 1 year: 2024 end-page: 20 ident: bib0039 article-title: Recent advances in microscale separation techniques for glycome analysis publication-title: J. Sep. Sci. – volume: 6 start-page: 1 year: 2024 end-page: 17 ident: bib0057 article-title: Light-emitting diode-based absorbance detectors for flow-through analysis in analytical chemistry: a tutorial publication-title: J. Chromat. Open. – volume: 28 start-page: 859 year: 2017 end-page: 865 ident: bib0072 article-title: A miniaturized linear wire ion trap with electron ionization and single photon ionization sources publication-title: J. Am. Soc. Mass Spectrom. – volume: 235 start-page: 622 year: 2016 end-page: 626 ident: bib0066 article-title: A. deep-UV, light-emitting diode-based absorption detector for benzene, toluene, ethylbenzene, and the xylene compounds publication-title: Sens. Actuators B: Chem. – volume: 4 start-page: 1 year: 2024 end-page: 24 ident: bib0086 article-title: Novel and rapid analytical platform development enabled by advances in 3D printing publication-title: Front. Anal. Sci. – volume: 1299 start-page: 1 year: 2024 end-page: 16 ident: bib0101 article-title: A review of the recent achievements and future trends on 3D printed microfluidic devices for bioanalytical applications publication-title: Anal. Chim. Acta. – volume: 131 start-page: 1 year: 2023 end-page: 39 ident: bib0106 article-title: Micro/nano functional devices fabricated by additive manufacturing publication-title: Prog. Mater. Sci. – volume: 1299 start-page: 1 year: 2024 end-page: 16 ident: bib0116 article-title: A review of the recent achievements and future trends on 3D printed microfluidic devices for bioanalytical applications publication-title: Anal. Chim. Acta – volume: 167 start-page: 103 year: 2017 end-page: 110 ident: bib0056 article-title: Fiber-optic sensor integrated with lab-on-valve manifold for colorimetric determination of free chlorine in water publication-title: Talanta – volume: 191 start-page: 1 year: 2024 end-page: 16 ident: bib0120 article-title: Inertial microfluidic mixer for biological CubeSat missions publication-title: Microchim. Acta. – volume: 31 start-page: 79 year: 2015 end-page: 85 ident: bib0016 article-title: Lab-on-a-chip hyphenation with mass spectrometry: strategies for bioanalytical applications publication-title: Curr. Opin. Biotechnol. – volume: 1370 start-page: 33 year: 2014 end-page: 39 ident: bib0032 article-title: High-performance liquid chromatography on glass chips using precisely defined porous polymer monoliths as particle retaining elements publication-title: J. Chromatogr. A. – volume: 47 start-page: 530 year: 2013 end-page: 538 ident: bib0059 article-title: Nickel nanoparticle-chitosan-reduced graphene oxide-modified screen-printed electrodes for enzyme-free glucose sensing in portable microfluidic devices publication-title: Biosens. Bioelectron. – volume: 15 start-page: 3627 year: 2015 end-page: 3637 ident: bib0037 article-title: 3D printed microfluidics for biological applications publication-title: Lab Chip – volume: 92 start-page: 11485 year: 2020 end-page: 11497 ident: bib0010 article-title: Miniaturized LC in molecular omics publication-title: Anal. Chem. – volume: 11 start-page: 21600 year: 2021 end-page: 21606 ident: bib0085 article-title: Realizing new designs of multiplexed electrode chips by 3-D printed masks publication-title: RSC Adv. – volume: 45 start-page: 165 year: 2024 end-page: 198 ident: bib0040 article-title: Recent developments in capillary and microchip electroseparations of peptides (2021-mid-2023) publication-title: Electrophoresis – volume: 22 start-page: 1 year: 2022 end-page: 33 ident: bib0115 article-title: Microfluidic point-of-care (POC) devices in early diagnosis: a review of opportunities and challenges publication-title: Sensors – reference: . – volume: 25 start-page: 458 year: 2006 end-page: 466 ident: bib0045 article-title: Dwell volume revisited publication-title: LCGC North Am. – volume: 14 start-page: 47 year: 2021 end-page: 63 ident: bib0099 article-title: 3D printed electrochemical sensors publication-title: Annu. Rev. Anal. Chem. – volume: 11 start-page: 390 year: 2021 ident: bib0102 article-title: Extrusion-based 3D printing applications of PLA composites: a review publication-title: Coatings – volume: 15 year: 2025 ident: bib0103 article-title: Comparison of mechanical properties of different 3D printing technologies publication-title: Sci. Rep. – volume: 90 start-page: 283 year: 2018 end-page: 301 ident: bib0013 article-title: Advances in microchip liquid chromatography publication-title: Anal. Chem. – start-page: 1 year: 2016 end-page: 3 ident: bib0076 article-title: Development of a portable, low cost, plasma ionization source coupled to a mass spectrometer for surface analysis publication-title: IEEE SENSORS – volume: 92 start-page: 66 year: 2013 end-page: 74 ident: bib0051 article-title: Internal and external quality assessment of mandarins on-tree and at harvest using a portable NIR spectrophotometer publication-title: Comput. Electron. Agric. – volume: 6 start-page: 1 year: 2016 end-page: 8 ident: bib0054 article-title: Ultra-portable, wireless smartphone spectrometer for rapid, non-destructive testing of fruit ripeness publication-title: Sci. Rep. – volume: 150 start-page: 135 year: 2016 end-page: 141 ident: bib0052 article-title: A handheld laser-induced fluorescence detector for multiple applications publication-title: Talanta – volume: 31 start-page: 480 year: 2012 end-page: 485 ident: bib0058 article-title: A novel microfluidic immunoassay system based on electrochemical immunosensors: an application for the detection of NT-proBNP in whole blood publication-title: Biosens. Bioelectron. – volume: 100 year: 2025 ident: bib0110 article-title: Strengthening the mechanical properties of 3D printed thermoplastic elastomer by blending with acrylonitrile butadiene styrene, polypropylene and polyethylene publication-title: Phys. Scr. – volume: 87 start-page: 1381 year: 2015 end-page: 1386 ident: bib0069 article-title: LED-based, U.V. Absorption, detector with low detection limits for capillary liquid chromatography publication-title: Anal. Chem. – volume: 16 start-page: 3604 year: 2016 end-page: 3614 ident: bib0068 article-title: An inline spectrophotometer on a centrifugal microfluidic platform for real-time protein determination and calibration publication-title: Lab Chip – volume: 86 start-page: 3240 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0036 article-title: Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences publication-title: Anal. Chem. doi: 10.1021/ac403397r – ident: 10.1016/j.jcoa.2025.100241_bib0080 – volume: 910 start-page: 84 year: 2019 ident: 10.1016/j.jcoa.2025.100241_bib0090 article-title: 3D-Printed stationary phases with ordered morphology: state of the art and future development in liquid chromatography publication-title: Anal. Chim. Acta. doi: 10.1016/j.aca.2016.01.012 – volume: 1158 start-page: 1 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0082 article-title: Miniaturized analytical methods for determination of environmental contaminants of emerging concern–a review publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2020.11.040 – volume: 64 start-page: 12372 year: 2025 ident: 10.1016/j.jcoa.2025.100241_bib0044 article-title: Microfluidic precision manufacture of high performance liquid chromatographic microspheres publication-title: Angew. Chem. Int. Ed. – volume: 81 start-page: 3714 year: 2009 ident: 10.1016/j.jcoa.2025.100241_bib0108 article-title: Hard top soft bottom microfluidic devices for cell culture and chemical analysis publication-title: Anal. Chem. doi: 10.1021/ac802178u – start-page: 3124 issue: 86 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0088 article-title: Cost-effective three-dimensional printing of visibly transparent microchips within minutes publication-title: Anal. Chem. doi: 10.1021/ac4041857 – volume: 4 start-page: e194 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0104 article-title: 3D bioprinting and its innovative approach for biomedical applications publication-title: Med. Comm. – volume: 1370 start-page: 33 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0032 article-title: High-performance liquid chromatography on glass chips using precisely defined porous polymer monoliths as particle retaining elements publication-title: J. Chromatogr. A. doi: 10.1016/j.chroma.2014.10.008 – volume: 160 start-page: 1 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0006 article-title: Advances in application and innovation of microfluidic platforms for pharmaceutical analysis publication-title: TrAC, Trends Anal. Chem. doi: 10.1016/j.trac.2023.116951 – volume: 28 start-page: 859 year: 2017 ident: 10.1016/j.jcoa.2025.100241_bib0072 article-title: A miniaturized linear wire ion trap with electron ionization and single photon ionization sources publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-017-1607-1 – volume: 5 start-page: 14 year: 2022 ident: 10.1016/j.jcoa.2025.100241_bib0105 article-title: 3D bioprinting: current status and trends—a guide to the literature and industrial practice publication-title: Bio-Des. Manuf. doi: 10.1007/s42242-021-00165-0 – volume: 11 start-page: 21600 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0085 article-title: Realizing new designs of multiplexed electrode chips by 3-D printed masks publication-title: RSC Adv. doi: 10.1039/D1RA03482K – ident: 10.1016/j.jcoa.2025.100241_bib0077 – volume: 128 start-page: 1 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0063 article-title: Advances in portable x-ray fluorescence (PXRF) for environmental, pedological, and agronomic applications publication-title: Adv. Agron. doi: 10.1016/B978-0-12-802139-2.00001-9 – volume: 46 start-page: 1 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0008 article-title: Recent advances in miniaturization of portable liquid chromatography with emphasis on detection publication-title: J. Sep. Sci. doi: 10.1002/jssc.202300283 – volume: 12 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0113 article-title: Simple microfluidic devices for in situ detection of water contamination: a state-of-art review publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2024.1355768 – volume: 21 start-page: 691 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0025 article-title: High throughput UHPLC-MS-based lipidomics using vacuum jacketed columns publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.1c00836 – volume: 1274 start-page: 161 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0033 article-title: Electrochromatography on acrylate-based monolith in cyclic olefin copolymer microchip: an attractive technology publication-title: Microchip Cap. Electrophor. Prot. doi: 10.1007/978-1-4939-2353-3_14 – volume: 90 start-page: 283 year: 2018 ident: 10.1016/j.jcoa.2025.100241_bib0013 article-title: Advances in microchip liquid chromatography publication-title: Anal. Chem. doi: 10.1021/acs.analchem.7b04329 – volume: 45 start-page: 165 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0040 article-title: Recent developments in capillary and microchip electroseparations of peptides (2021-mid-2023) publication-title: Electrophoresis doi: 10.1002/elps.202300152 – volume: 86 start-page: 11657 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0095 article-title: 3D-printed paper spray ionization cartridge with fast wetting and continuous solvent supply features publication-title: Anal. Chem. doi: 10.1021/ac502785j – volume: 3 start-page: 1 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0114 article-title: 3D-Printed microfluidics and potential biomedical applications publication-title: Front. Nanotechnol. doi: 10.3389/fnano.2021.609355 – volume: 150 start-page: 135 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0052 article-title: A handheld laser-induced fluorescence detector for multiple applications publication-title: Talanta doi: 10.1016/j.talanta.2015.12.018 – volume: 67 start-page: 1215 year: 2013 ident: 10.1016/j.jcoa.2025.100241_bib0049 article-title: A review on the applications of portable near-infrared spectrometers in the agro-food industry publication-title: Appl. Spectrosc. doi: 10.1366/13-07228 – volume: 11 start-page: 1 year: 2025 ident: 10.1016/j.jcoa.2025.100241_bib0121 article-title: Adoption of microfluidic MEA technology for electrophysiology of 3D neuronal networks exposed to suborbital conditions publication-title: npj Microgravity doi: 10.1038/s41526-025-00476-x – volume: 15 start-page: 3627 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0037 article-title: 3D printed microfluidics for biological applications publication-title: Lab Chip doi: 10.1039/C5LC00685F – volume: 235 start-page: 622 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0066 article-title: A. deep-UV, light-emitting diode-based absorption detector for benzene, toluene, ethylbenzene, and the xylene compounds publication-title: Sens. Actuators B: Chem. doi: 10.1016/j.snb.2016.05.122 – volume: 1103 start-page: 11 year: 2020 ident: 10.1016/j.jcoa.2025.100241_bib0028 article-title: Miniaturized liquid chromatography focusing on analytical columns and mass spectrometry: a review publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2019.12.064 – volume: 16 start-page: 71 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0087 article-title: Beginner's guide to micro-and nanoscale electrochemical additive manufacturing publication-title: Annu. Rev. Anal. Chem. doi: 10.1146/annurev-anchem-091522-122334 – volume: 70 start-page: 159 year: 2013 ident: 10.1016/j.jcoa.2025.100241_bib0050 article-title: Rapid phenotyping of the tomato fruit model, Micro-Tom, with a portable VIS–NIR spectrometer publication-title: Plant Physiol. Biochem. doi: 10.1016/j.plaphy.2013.05.019 – volume: 16 start-page: 3604 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0068 article-title: An inline spectrophotometer on a centrifugal microfluidic platform for real-time protein determination and calibration publication-title: Lab Chip doi: 10.1039/C6LC00542J – volume: 191 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0120 article-title: Inertial microfluidic mixer for biological CubeSat missions publication-title: Microchim. Acta. doi: 10.1007/s00604-024-06726-1 – volume: 158 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0112 article-title: 3D printed microfluidics for bioanalysis: a review of recent advancements and applications publication-title: TrAC, Trends Anal. Chem. doi: 10.1016/j.trac.2022.116892 – volume: 8 start-page: 1 year: 2020 ident: 10.1016/j.jcoa.2025.100241_bib0002 article-title: Recent advances in microfluidics-based chromatography—a mini review publication-title: Separations doi: 10.3390/separations8010003 – volume: 3 start-page: 7 year: 2019 ident: 10.1016/j.jcoa.2025.100241_bib0005 article-title: Microfluidics devices applied to radionuclides separation in acidic media for the nuclear fuel cycle publication-title: Micro Nano Eng. doi: 10.1016/j.mne.2019.02.006 – volume: 89 start-page: 11419 year: 2017 ident: 10.1016/j.jcoa.2025.100241_bib0096 article-title: 3D-printed paper spray ionization cartridge with integrated desolvation feature and ion optics publication-title: Anal. Chem. doi: 10.1021/acs.analchem.7b02490 – ident: 10.1016/j.jcoa.2025.100241_bib0015 – ident: 10.1016/j.jcoa.2025.100241_bib0089 doi: 10.1039/C4AN01476F – volume: 210 start-page: 149 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0061 article-title: A sensitive molecular imprinted electrochemical sensor based on gold nanoparticles decorated graphene oxide: application to selective determination of tyrosine in milk publication-title: Sens. Actuators B: Chem. doi: 10.1016/j.snb.2014.12.098 – volume: 6 start-page: 1 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0054 article-title: Ultra-portable, wireless smartphone spectrometer for rapid, non-destructive testing of fruit ripeness publication-title: Sci. Rep. doi: 10.1038/srep32504 – volume: 25 start-page: 458 year: 2006 ident: 10.1016/j.jcoa.2025.100241_bib0045 article-title: Dwell volume revisited publication-title: LCGC North Am. – volume: 45 start-page: 69 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0041 article-title: Trends and challenges in microfluidic methods for protein manipulation—a review publication-title: Electrophoresis doi: 10.1002/elps.202300056 – volume: 1470 start-page: 76 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0024 article-title: Experimental evaluation of chromatographic performance of capillary and microfluidic columns with linear or curved channels publication-title: J. Chromatogr. A. doi: 10.1016/j.chroma.2016.10.004 – volume: 92 start-page: 1341 year: 2020 ident: 10.1016/j.jcoa.2025.100241_bib0100 article-title: 3D printing in analytical chemistry: current state and future publication-title: Pure Appl. Chem. doi: 10.1515/pac-2020-0206 – volume: 874 start-page: 26 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0117 article-title: Potentiometric analytical microsystem based on the integration of a gas-diffusion step for on-line ammonium determination in water recycling processes in manned space missions publication-title: Anal. Chim. Acta. doi: 10.1016/j.aca.2014.12.038 – volume: 15 issue: 1–8 year: 2025 ident: 10.1016/j.jcoa.2025.100241_bib0103 article-title: Comparison of mechanical properties of different 3D printing technologies publication-title: Sci. Rep. – ident: 10.1016/j.jcoa.2025.100241_bib0079 – volume: 6 start-page: 8180 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0060 article-title: A simple microfluidic electrochemical HPLC detector for quantifying Fenton reactivity from welding fumes publication-title: Anal. Methods. doi: 10.1039/C4AY01534G – volume: 27 start-page: 1197 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0071 article-title: Direct and sensitive detection of CWA simulants by active capillary plasma ionization coupled to a handheld ion trap mass spectrometer publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-016-1374-4 – volume: 13 start-page: 45 year: 2020 ident: 10.1016/j.jcoa.2025.100241_bib0111 article-title: 3D printed microfluidics publication-title: Annu. Rev. Anal. Chem. doi: 10.1146/annurev-anchem-091619-102649 – start-page: 1 year: 2025 ident: 10.1016/j.jcoa.2025.100241_bib0097 article-title: On-body electrochemical measurement of sweat lactate with the use of paper-based fluidics and 3D-printed flexible wearable biosensor publication-title: Anal. Bioanal. Chem. – volume: 1421 start-page: 203 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0065 article-title: Absorbance detector for capillary electrophoresis based on light-emitting diodes and photodiodes for the deep-ultraviolet range publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2015.06.005 – ident: 10.1016/j.jcoa.2025.100241_bib0078 – volume: 1228 start-page: 2 year: 2012 ident: 10.1016/j.jcoa.2025.100241_bib0021 article-title: The current revolution in column technology: how it began, where is it going? publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2011.07.014 – volume: 838 start-page: 58 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0092 article-title: Three-dimensional printed sample load/inject valves enabling online monitoring of extracellular calcium and zinc ions in living rat brains publication-title: Anal. Chim. Acta. doi: 10.1016/j.aca.2014.06.037 – volume: 53 start-page: 98 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0004 article-title: Recent applications of nano-liquid chromatography in food safety and environmental monitoring: a review publication-title: Crit. Rev. Anal. Chem. doi: 10.1080/10408347.2021.1938968 – volume: 1333 start-page: 18 year: 2019 ident: 10.1016/j.jcoa.2025.100241_bib0091 article-title: 3D-Printed stationary phases with ordered morphology: state of the art and future development in liquid chromatography publication-title: Chromatographia doi: 10.1016/j.chroma.2014.01.043 – volume: 7 start-page: 771 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0107 article-title: Jetting-based bioprinting: process, dispense physics, and applications publication-title: Bio-Des. Manuf. doi: 10.1007/s42242-024-00285-3 – volume: 226 start-page: 1 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0119 article-title: AstroBio-CubeSat: a lab-in-space for chemiluminescence-based astrobiology experiments publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2023.115110 – volume: 31 start-page: 480 issue: 1 year: 2012 ident: 10.1016/j.jcoa.2025.100241_bib0058 article-title: A novel microfluidic immunoassay system based on electrochemical immunosensors: an application for the detection of NT-proBNP in whole blood publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2011.11.021 – volume: 6 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0003 article-title: Microchip gas chromatographic columns dedicated for space exploration: stationary phase coating, setup optimization and evaluation of column performances publication-title: J. Chromatogr. Open doi: 10.1016/j.jcoa.2024.100180 – volume: 14 start-page: 1 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0020 article-title: Polymeric and paper-based lab-on-a-chip devices in food safety: a review publication-title: Micromachines doi: 10.3390/mi14050986 – volume: 1668 start-page: 1 year: 2022 ident: 10.1016/j.jcoa.2025.100241_bib0026 article-title: Current advances and applications of online sample preparation techniques for miniaturized liquid chromatography systems publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2022.462925 – volume: 92 start-page: 66 year: 2013 ident: 10.1016/j.jcoa.2025.100241_bib0051 article-title: Internal and external quality assessment of mandarins on-tree and at harvest using a portable NIR spectrophotometer publication-title: Comput. Electron. Agric. doi: 10.1016/j.compag.2013.01.004 – volume: 9 start-page: 1 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0083 article-title: Emerging contaminants in wastewater: a critical review on occurrence, existing legislations, risk assessment, and sustainable treatment alternatives publication-title: J. Environ. Chem. Eng. doi: 10.1016/j.jece.2021.105966 – volume: 3 start-page: 2475 year: 2018 ident: 10.1016/j.jcoa.2025.100241_bib0031 article-title: Advances in optical sensing and bioanalysis enabled by 3D printing publication-title: ACS Sens. doi: 10.1021/acssensors.8b01085 – volume: 3 start-page: 1893 year: 2020 ident: 10.1016/j.jcoa.2025.100241_bib0017 article-title: Intelligent microfluidics: the convergence of machine learning and microfluidics in materials science and biomedicine publication-title: Matter doi: 10.1016/j.matt.2020.08.034 – volume: 85 start-page: 543 year: 2013 ident: 10.1016/j.jcoa.2025.100241_bib0027 article-title: Fundamentals for LC miniaturization publication-title: Anal. Chem. doi: 10.1021/ac303317c – volume: 36 start-page: 1 year: 2022 ident: 10.1016/j.jcoa.2025.100241_bib0029 article-title: Nano-LC: an updated review publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.5317 – volume: 9 start-page: 1 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0093 article-title: 3D printed microfluidic devices with integrated valves publication-title: Biomicrofluidics doi: 10.1063/1.4905840 – volume: 47 start-page: 530 year: 2013 ident: 10.1016/j.jcoa.2025.100241_bib0059 article-title: Nickel nanoparticle-chitosan-reduced graphene oxide-modified screen-printed electrodes for enzyme-free glucose sensing in portable microfluidic devices publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2013.03.051 – volume: 6 start-page: 1 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0001 article-title: Green profile tools: current status and future perspectives publication-title: Adv. Sample Prep. – volume: 4 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0086 article-title: Novel and rapid analytical platform development enabled by advances in 3D printing publication-title: Front. Anal. Sci. doi: 10.3389/frans.2024.1505510 – volume: 100 year: 2025 ident: 10.1016/j.jcoa.2025.100241_bib0110 article-title: Strengthening the mechanical properties of 3D printed thermoplastic elastomer by blending with acrylonitrile butadiene styrene, polypropylene and polyethylene publication-title: Phys. Scr. doi: 10.1088/1402-4896/adbc2e – volume: 11 start-page: 390 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0102 article-title: Extrusion-based 3D printing applications of PLA composites: a review publication-title: Coatings doi: 10.3390/coatings11040390 – volume: 12 start-page: 1 year: 2022 ident: 10.1016/j.jcoa.2025.100241_bib0118 article-title: Microvalve array fabrication using selective PDMS (polydimethylsiloxane) bonding through perfluorooctyl-trichlorosilane passivation for long-term space exploration publication-title: Sci. Rep. doi: 10.1038/s41598-022-16574-9 – volume: 1381 start-page: 110 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0023 article-title: Repetitive injection method: a tool for investigation of injection zone formation and its compression in microfluidic liquid chromatography publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2015.01.002 – volume: 10 start-page: 1 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0034 article-title: Advances in monoliths and related porous materials for microfluidics publication-title: Biomicrofluidics doi: 10.1063/1.4948507 – volume: 131 start-page: 1 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0106 article-title: Micro/nano functional devices fabricated by additive manufacturing publication-title: Prog. Mater. Sci. doi: 10.1016/j.pmatsci.2022.101020 – volume: 126 start-page: 110 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0094 article-title: 3D-printed and CNC milled flow-cells for chemiluminescence detection publication-title: Talanta doi: 10.1016/j.talanta.2014.03.047 – volume: 45 start-page: 121 year: 2013 ident: 10.1016/j.jcoa.2025.100241_bib0062 article-title: Development and application of portable, hand-held X-ray fluorescence spectrometers publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2013.01.006 – volume: 167 start-page: 103 year: 2017 ident: 10.1016/j.jcoa.2025.100241_bib0056 article-title: Fiber-optic sensor integrated with lab-on-valve manifold for colorimetric determination of free chlorine in water publication-title: Talanta doi: 10.1016/j.talanta.2017.02.014 – volume: 1299 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0116 article-title: A review of the recent achievements and future trends on 3D printed microfluidic devices for bioanalytical applications publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2024.342429 – volume: 31 start-page: 79 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0016 article-title: Lab-on-a-chip hyphenation with mass spectrometry: strategies for bioanalytical applications publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2014.08.009 – volume: 165 start-page: 240 year: 2017 ident: 10.1016/j.jcoa.2025.100241_bib0053 article-title: Confocal laserinduced fluorescence detector for narrow capillary system with yoctomole limit of detection publication-title: Talanta doi: 10.1016/j.talanta.2016.12.056 – volume: 6 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0007 article-title: What still hinders the routine application of miniaturized liquid chromatography beyond the omics sciences? publication-title: J. Chromatogr. Open – volume: 1421 start-page: 2 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0009 article-title: Instrument platforms for nano liquid chromatography publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2015.07.090 – volume: 87 start-page: 8867 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0075 article-title: Real-time sample analysis using a sampling probe and miniature mass spectrometer publication-title: Anal. Chem. doi: 10.1021/acs.analchem.5b01943 – volume: 17 start-page: 21 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0038 article-title: Why use miniaturized columns in liquid chromatography? Benefits and challenges publication-title: Column – volume: 122 start-page: 1 year: 2020 ident: 10.1016/j.jcoa.2025.100241_bib0043 article-title: Miniaturization of liquid chromatography coupled to mass spectrometry: 1. Current trends on miniaturized LC columns publication-title: TrAC, Trends Anal. Chem. doi: 10.1016/j.trac.2019.115735 – volume: 140 start-page: 3406 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0073 article-title: Development of a miniature mass spectrometer with continuous atmospheric pressure interface publication-title: Analyst doi: 10.1039/C5AN00462D – volume: 89 start-page: 4177 year: 2017 ident: 10.1016/j.jcoa.2025.100241_bib0081 article-title: Mini mass spectrometer integrated with a miniature ion funnel publication-title: Anal. Chem. doi: 10.1021/acs.analchem.7b00195 – volume: 1299 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0101 article-title: A review of the recent achievements and future trends on 3D printed microfluidic devices for bioanalytical applications publication-title: Anal. Chim. Acta. doi: 10.1016/j.aca.2024.342429 – volume: 140 start-page: 593 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0055 article-title: Moving your laboratories to the field – advantages and limitations of the use of field portable instruments in environmental sample analysis publication-title: Environ. Res. doi: 10.1016/j.envres.2015.05.017 – volume: 14 start-page: 47 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0099 article-title: 3D printed electrochemical sensors publication-title: Annu. Rev. Anal. Chem. doi: 10.1146/annurev-anchem-091120-093659 – volume: 86 start-page: 2909 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0074 article-title: Mini 12, miniature mass spectrometer for clinical and other applications - introduction and characterization publication-title: Anal. Chem. doi: 10.1021/ac403766c – volume: 43 start-page: 2628 year: 2014 ident: 10.1016/j.jcoa.2025.100241_bib0048 article-title: The role of mobile instrumentation in novel applications of Raman spectroscopy: archaeometry, geosciences, and forensics publication-title: Chem. Soc. Rev. doi: 10.1039/c3cs60263j – start-page: 1 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0076 article-title: Development of a portable, low cost, plasma ionization source coupled to a mass spectrometer for surface analysis publication-title: IEEE SENSORS – volume: 87 start-page: 250 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0035 article-title: Advances and recent trends in the field of monolithic columns for chromatography publication-title: Anal. Chem. doi: 10.1021/ac504059c – volume: 72 start-page: 77 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0064 article-title: A review of the handheld X-ray fluorescence spectrometer as a tool for field geologic investigations on Earth and in planetary surface exploration publication-title: Appl. Geochem. doi: 10.1016/j.apgeochem.2016.07.003 – volume: 26 start-page: 240 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0070 article-title: Design of portable mass spectrometers with handheld probes: aspects of the sampling and miniature pumping systems publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-014-1026-5 – volume: 219 start-page: 1 year: 2022 ident: 10.1016/j.jcoa.2025.100241_bib0012 article-title: Greenness of lab-on-a-chip devices for analytical processes: advances & future prospects publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2022.114914 – volume: 82 start-page: 443 year: 2019 ident: 10.1016/j.jcoa.2025.100241_bib0030 article-title: 3D-printed stationary phases with ordered morphology: state of the art and future development in liquid chromatography publication-title: Chromatographia doi: 10.1007/s10337-018-3671-5 – volume: 965 start-page: 131 year: 2017 ident: 10.1016/j.jcoa.2025.100241_bib0067 article-title: 3D printed LED based on-capillary detector housing with integrated slit publication-title: Anal. Chim. Acta. doi: 10.1016/j.aca.2017.02.020 – volume: 29 start-page: 351 year: 2010 ident: 10.1016/j.jcoa.2025.100241_bib0042 article-title: Microchip technology in mass spectrometry publication-title: Mass Spectrom. Rev. – volume: 40 start-page: 839 year: 2017 ident: 10.1016/j.jcoa.2025.100241_bib0019 article-title: Green chemistry: analytical and chromatography publication-title: J. Liq. Chromatogr. Relat. Technol. doi: 10.1080/10826076.2017.1373672 – volume: 22 start-page: 1 year: 2022 ident: 10.1016/j.jcoa.2025.100241_bib0115 article-title: Microfluidic point-of-care (POC) devices in early diagnosis: a review of opportunities and challenges publication-title: Sensors – volume: 33 start-page: 850 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0046 article-title: What is “dead” volume and why should chromatographers worry about it? publication-title: LCGC North Am. – volume: 87 start-page: 1381 year: 2015 ident: 10.1016/j.jcoa.2025.100241_bib0069 article-title: LED-based, U.V. Absorption, detector with low detection limits for capillary liquid chromatography publication-title: Anal. Chem. doi: 10.1021/ac504275m – volume: 47 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0039 article-title: Recent advances in microscale separation techniques for glycome analysis publication-title: J. Sep. Sci. doi: 10.1002/jssc.202400170 – volume: 92 start-page: 11485 year: 2020 ident: 10.1016/j.jcoa.2025.100241_bib0010 article-title: Miniaturized LC in molecular omics publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c01436 – volume: 6 start-page: 1 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0057 article-title: Light-emitting diode-based absorbance detectors for flow-through analysis in analytical chemistry: a tutorial publication-title: J. Chromat. Open. doi: 10.1016/j.jcoa.2024.100191 – volume: 42 start-page: 49 year: 2008 ident: 10.1016/j.jcoa.2025.100241_bib0109 article-title: Design and fabrication of three-dimensional scaffolds for tissue engineering of human heart valves publication-title: Eur .Surg. Res. doi: 10.1159/000168317 – volume: 171 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0098 article-title: On-site electrochemical sensor for carbamazepine monitoring in aquatic environments publication-title: J. Electrochem. Soc. doi: 10.1149/1945-7111/ad9b53 – volume: 2 start-page: 1 year: 2022 ident: 10.1016/j.jcoa.2025.100241_bib0011 article-title: Nanoscale separation: recent achievements publication-title: J. Chromatogr. Open. doi: 10.1016/j.jcoa.2022.100066 – volume: 113 start-page: 2550 year: 2013 ident: 10.1016/j.jcoa.2025.100241_bib0022 article-title: Advances in microfluidic materials, functions, integration, and applications publication-title: Chem. Rev. doi: 10.1021/cr300337x – volume: 121 start-page: 2585 year: 2024 ident: 10.1016/j.jcoa.2025.100241_bib0014 article-title: Nanobiosensors based on on-site detection approaches for rapid pesticide sensing in the agricultural arena: a systematic review of the current status and perspectives publication-title: Biotechnol. Bioeng. doi: 10.1002/bit.28764 – volume: 143 start-page: 1 year: 2021 ident: 10.1016/j.jcoa.2025.100241_bib0084 article-title: Green miniaturized technologies in analytical and bioanalytical chemistry publication-title: TrAC, Trends Anal. Chem. doi: 10.1016/j.trac.2021.116383 – volume: 13 start-page: 136 year: 2023 ident: 10.1016/j.jcoa.2025.100241_bib0018 article-title: Microfluidic gut-on-a-chip: fundamentals and challenges publication-title: Biosensors doi: 10.3390/bios13010136 – volume: 88 start-page: 2 year: 2016 ident: 10.1016/j.jcoa.2025.100241_bib0047 article-title: Miniature and fieldable mass spectrometers: recent advances publication-title: Anal. Chem. doi: 10.1021/acs.analchem.5b03070 |
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| Title | Chemical analysis using miniaturized and Portable 3D printed systems: Where are we now? |
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